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硒蛋白M及其与重大疾病的关系
Selenoprotein M and Its Effects on Diseases
硒蛋白M(SelM)是2002年应用生物信息学方法发现的一种内质网硒蛋白,其二级结构中含有一个氧化还原调节基序CXXU,且该蛋白在脑中大量表达。SelM因具有维持机体氧化还原水平、保护神经细胞和调节钙稳态平衡等重要作用,近年成为研究热点。本文结合本课题组的研究结果,对硒蛋白M的最新研究进展、生物功能、与重大疾病的关系及今后研究方向等方面进行了综述和展望。
Selenoprotein M (SelM) was discovered in 2002 by bioinformatics analysis. SelM is located in the endoplasmic reticulum, containing a common redox motif cysteine-X-X-selenocysteine. SelM attracts great attention due to its high expression in brain and its potential roles in antioxidative defense, neuroprotective function and cytosolic calcium regulation. This paper reviews recent research progress in SelM, especially its biological function and its relation with diseases, together with the author's work on SelM. The prospect of SelM research is also discussed in this paper.
Contents
1 Introduction
2 The primary structure of SelM and its distribution
3 The spatial structure of SelM
4 The biological function of SelM
4.1 Antioxidative function
4.2 Interaction with metal ions
4.3 Calcium regulation
5 Relation between SelM and diseases
5.1 SelM and AD
5.2 SelM and reproduction and development
5.3 SelM and cancer prevention
6 Perspectives
硒蛋白M
selenoprotein M
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