中文 |
English |
Email Alert
碳纳米材料在生物医学领域的应用现状及展望
Application Status and Prospect of Carbon-Based Nanomaterials in Biomedical Field
随着纳米技术的飞速发展,纳米材料已成为一种新型材料。纳米材料具有独特的物理化学性质,如小尺寸效应、巨大比表面积、极高的反应活性、量子效应等,这些特性使纳米科学成为当今世界三大支柱科学之一。碳纳米材料是纳米材料领域重要的组成部分,主要包括碳纳米管、富勒烯、石墨烯、纳米钻石及其衍生物等。由于其独特的理化特性,它们在生物医学领域具有广泛的应用前景。另外,随着碳纳米材料的产业化,各种形式的碳纳米材料将以不同途径进入人们的生活,纳米材料的生物安全性问题正受到世界各国科学家的广泛关注。本文综述了这四类碳纳米材料在组织工程、药物/基因载体、生物成像、肿瘤治疗、抗病毒/抗菌、生物传感等生物医学领域的应用现状以及存在的生物安全问题, 最后,讨论了该领域未来的研究内容和方向以及亟待研究的重要问题。
Nanomaterials have become a new type of materials with a rapid development of nanotechnology. Nanomaterials have unique physical and chemical properties such as small size effect, large surface area, high reactivity, and quantum effects. These features make the nanoscience as one of the three pillars of the world science. Carbon-based nanomaterials are an important part of nanomaterials, they include carbon nanotubes, fullerene, graphene, nanodiamond and their derivatives. Due to their unique physical and chemical properties, carbon-based nanomaterials have broad applications in the biomedical field. In addition, with the industrialization of nanotechnology, various forms of carbon-based nanomaterials have come into human life in different ways, and the biosafety is increasingly attracting attention of scientists around the world. This article reviews the potential applications of all four types of carbon-based nanomaterials in the biomedical field including tissue engineering, drug/gene carrier, biological imaging, cancer treatment, anti-HIV/anti-bacterial activity, and biological sensing. In addition, the biosafety issue is also reviewed. Finally, we discuss the need for future research. Specifically, we identify the most important research topics, which urgently need to be studied. Contents
1 Introduction
2 The application of carbon-based nanomaterials in the biomedical field
2.1 Tissue engineering
2.2 Drug/gene carrier
2.3 Biological imaging
2.4 Cancer treatment
2.5 Anti-HIV/antibacterial activity
2.6 Biosensor
3 Biosafety assessment of carbon-based nanomaterials
4 Outlook
碳纳米材料
carbon-based nanomaterials
[1] Iijima S. Nature, 1991, 354: 56-58
[2] Samar J K, Bhardwaj A B, Himesh A B. Mat. Sci. Eng. C, 2007, 3: 441-449
[3] 但志刚(Dan Z G), 蔡建明(Cai J M), 倪瑾(Ni J). 药学实践杂志(Journal of Pharmaceutical Practice), 2009, 27: 167-169
[4] Marrs B, Andrews R, Rantell T, Pienkowski D. J. Biomed. Mater. Res. A, 2006, 77: 269-276
[5] Grausova L, Vacik J, Vorlicek V, Svorcik V, Slepicka P, Bilkova P, Vandrovcova M, Lisa V, Bacakova L. Diam. Relat. Mater., 2009, 18: 578-586
[6] Vandrovcova M, Vacik J, Svorcik V, Slepicka P, Kasalkova N, Vorlicek V, Lavrentiev V, Vosecek V, Grausova L, Lisa V, Bacakova L. Phys. Status Solidi. A, 2008, 205: 2252-2261
[7] Yudoh K, Karasawa R, Masuko K, Kato T. Int. J. Nanomedicine, 2009, 4: 233-239
[8] Yudoh K, Karasawa R, Masuko K, Kato T. Int. J. Nanomedicine, 2009, 4: 217-225
[9] 马海冰(Ma H B), 邰志新(Tai Z X), 孙东飞(Sun D F), 齐元园(Qi Y Y), 刘斌(Liu B), 闫兴斌(Yan X B). 材料导报B(Materials Review B), 2011, 25: 19-21
[10] Kalbacova M, Broz A, Kong J, Kalbac M. Carbon, 2010, 48: 4323-4329
[11] Lee W C, Lim C H, Shi H, Tang L A, Wang Y, Lim C T, Loh K P. ACS Nano, 2011, 5: 7334-7341
[12] Jan E, Kotov N A. Nano Lett., 2007, 7: 1123-1128
[13] Kam N W S, Jan E, Kotov N A. Nano Lett., 2009, 9: 273-278
[14] 赵文(Zhao W), 张志愿(Zhang Z J), 孙坚(Sun J), 郑家伟(Zheng J W), 蒋欣泉(Jiang X Q), 朱亚琴(Zhu Y Q), 王英(Wang Y), 蒋丽霞(Jiang L X). 中国组织工程研究(Journal of Clinical Rehabilitative Tissue Engeering Research), 2009, 13: 9237-9240
[15] Dugan L L, Gabrielsen J, Yu S, Lin T S, Choi D W. Neurobiol. Dis., 1996, 3: 129-135
[16] Dugan L L, Turetsky D M, Du C, Lobner D, Wheeler M, Almli C R, Shen C K, Luh T Y, Choi D W, Lin T S. Proc. Nati. Acad. Sci. USA, 1997, 94: 9434-9439
[17] Jin H, Chen W Q, Tang X W, Chiang L Y, Yang C Y, Schloss J V, Wu J Y. J. Neurosci. Res., 2000, 62: 600-607
[18] Kam N W, O'Connell M, Wisdom J A, Dai H J. Proc. Nati. Acad. Sci. USA, 2005, 102: 11600-11605
[19] Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H. Cancer Res., 2008, 68: 6652-6660
[20] 欧忠敏(Ou Z M), 吴宝艳(Wu B Y), 邢达(Xing D). 光学学报(Acta Optical Sinica), 2009, S1: 181-185
[21] Partha R, Mitchell L R, Lyon J L, Joshi P P, Conyers J L. ACS Nano. 2008, 2: 1950-1958
[22] Liu J H, Cao L, Luo P J, Yang S T, Lu F, Wang H, Meziani M J, Haque S A, Liu Y, Lacher S, Sun Y P. ACS Appl. Mater. Inter., 2010, 2: 1348-1389
[23] Venkatesan N, Yoshimitsu J, Ito Y, Shibata N, Takada K. Biomaterials, 2005, 26: 7154-7163
[24] Kellermann N, Bauer W, Hirsch A, Schade B, Ludwig K, Bottcher C. Angew. Chem., 2004, 116: 3019-3022
[25] 张雪莹(Zhang X Y). 太原理工大学硕士学位论文(Master Dissertation of Taiyuan University of Technology). 2011
[26] Liu Z, Robinson J T, Sun X, Dai H. J. Am. Chem. Soc., 2008, 130: 10876-10877
[27] Zhang L M, Xia J G, Zhao Q H, Liu L W, Zhang Z J. Small, 2010, 6: 537-544
[28] Sun X M, Liu Z, Welsher K, Robinson J T, Goodwin A, Zaric S, Dai H. Nano Res., 2008, 1: 203-212
[29] Yang X Y, Zhang X Y, Liu Z F, Ma Y F, Huang Y, Chen Y S. J. Phys. Chem. C, 2008, 112: 17554-17558
[30] Bao H Q, Pan Y Z, Ping Y, Sahoo N G, Wu T, Li L, Li J, Gan L H. Small, 2011, 7: 1569-1578.
[31] Huang H, Pierstorff E, Osawa E, Ho D. Nano Lett., 2007, 7: 3305-3314
[32] Chow E K, Zhang X Q, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D. Sci. Transl. Med. Org., 2011, 3: 1-11
[33] 周雪萍(Zhou X P). 山西大学硕士学位论文(Master Dissertation of Shanxi University). 2011
[34] Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand J P, Prato M, Kostarelos K, Bianco A. Angew. Chem. Int. Ed., 2004, 43: 5242-5246
[35] Liu Y, Wu D C, Zhang W D, Jiang X, He C B, Chung T S, Goh S H, Leong K W. Angew. Chem. Int. Ed., 2005, 44: 4782-4785
[36] Gao L Z, Nie L, Wang T H, Qin Y, Guo Z, Yang D, Yan X. ChemBioChem, 2006, 7: 239-242
[37] Zhang Z, Yang X Y, Zhang Y H, Zeng B, Wang S, Zhu T, Roden R B, Chen Y, Yang R. Clin. Cancer. Res., 2006, 12: 4933-4939
[38] Rui M M, Eisei N, Hiroyuki I, Waka N, Koji O, Kent D, Takeshi S, Tetsuro I, Tatsuya H, Eiichi N. Proc. Natl. Acad. Sci. USA, 2010, 107: 5339-5344
[39] Sitharaman B, Zakharian T Y, Saraf A, Misra P, Ashcroft J, Pan S, Pham Q P, Mikos A G, Wilson L J, Engler D A. Mol. Pharm., 2008, 5: 567-578
[40] Feng L Z, Zhang S, Liu Z G. Nanoscale, 2011, 3: 1252-1257
[41] Zhang L M, Lu Z X, Zhao Q H, Huang J, Shen H, Zhang Z J. Small, 2011, 7: 460-464
[42] Zhang X Q, Chen M, Lam R, Xu X, Osawa E, Ho D. ACS Nano, 2009, 3: 2609-2616
[43] Martin R, Alvaro M, Herance J R, Garcia H. ACS Nano, 2010, 4: 65-74
[44] Zhang P, Yang J H, Li W C, Wang W, Liu C, Griffith M, Liu W. J. Mater. Chem., 2011, 21: 7755-7764
[45] Heller D A, Baik S, Eurell T E, Strano M S. Adv. Mater., 2005, 17: 2793-2799
[46] Choi J H, Nquyen F T, Barone P W, Heller D A, Moll A E, Patel D, Boppart S A, Strano M S. Nano Lett., 2007, 7: 861-867
[47] Leeuw T K, Reith R M, Simonette R A, Harden M E, Cherukuri P, Tsyboulski D A, Beckingha K M, Weisman R B. Nano Lett., 2007, 7: 2650-2654
[48] Huang H D, Zou M J, Xu X, Wang X Y, Liu F, Li N. TrAC Trend Anal. Chem., 2011, 30: 1109-1119
[49] Liu K P, Zhang J J, Cheng F F, Zheng T T, Wang C M, Zhu J J. Mater. Chem., 2011, 21: 12034-12040
[50] Zhu S J, Zhang J H, Qiao C Y, Tang S J, Li Y F, Yuan W J, Li B, Tian L, Liu F, Hu R, Gao H N, Wei H T, Zhang H, Sun H C, Yang B. Chem. Commun., 2011, 6858-6860
[51] 王雪(Wang X). 上海交通大学硕士学位论文(Master Dissertation of Shanghai Jiaotong University). 2009
[52] Meng J, Xing J M, Wang Y Z, Lu J, Zhao Y L, Gao Y X, Wang P C, Jia L, Liang X J. Nanoscale, 2011, 3: 4713-4719
[53] Kato H, Kanazawa Y, Okumura M, Taninaka A, Yokawa T, Shinohara H. J. Am. Chem. Soc., 2003, 125: 4391-4397
[54] 卢兴(Lu X), 徐建勋(Xu J X), 施祖进(Shi Z J), 孙宝云(Sun B Y), 顾镇南(Gu Z N), 刘洪东(Liu H D), 韩鸿宾(Han H B). 高等学校化学学报(Chemical Journal of Chinese Universitys), 2004, 25: 697-700
[55] Mikawa M, Kato H, Okumura M, Narazaki M, Kanazawa Y, Miwa N, Shinohara H. Bioconjug. Chem., 2001, 12: 510-514
[56] 刘凯敏(Liu K M), 张钧(Zhang J), 邢更妹(Xing G M), 赵宇亮(Zhao Y L). 应用化学(Chinese Journal of Applied Chemistry), 2007, 24: 90-94
[57] Chen W, Yi P, Zhang Y, Zhang L, Deng Z, Zhang Z. ACS Appl. Mater. Interfaces., 2011, 3: 4085-4091
[58] Shen A J, Li D L, Cai X J, Dong C Y, Dong H Q, Wen H Y, Dai G H, Wang P I, Li Y Y. J. Biomed. Mater. Res. A, 2012, 100(9): 2499-2506. doi: 10.1002/jbm. a. 34148
[59] Manus L M, Mastarone D J, Waters E A, Zhang X Q, Schultz-Sikma E A, Macrenaris K W, Ho D, Meade T J. Nano Lett., 2010, 10: 484-489
[60] 周非凡(Zhou F F), 邢达(Xing D), 宋盛(Song S), 欧忠敏(Ou Z M), 陈伟(Chen W). 中国激光(Chinese Journal of Lasers), 2009, 10: 2676-2679
[61] Ghosh S, Dutta S, Gomes E, Carroll D, Dagostino R J, Olson J, Guthold M, Gmeiner W H. ACS Nano, 2009, 3: 2667-2673
[62] 刘爱红(Liu A H), 孙康宁(Sun K N), 李爱民(Li A M), 魏源(Wei Y), 孙昌(Sun C). 功能材料(Journal of Functional Materials). 2006, 8: 1322-1324
[63] Tokuyama H, Yamago S, Nakamura E, Shiraki T, Sugiura Y. J. Am. Chem. Soc., 1993, 115: 7918-7919
[64] Godal A, Nilsen N O, Klaveness J, Branden J E, Nesland J M, Peng Q. J. Environ. Pathol. Toxicol. Oncol., 2006, 25: 109-126
[65] Markovic Z, Trajkovic V. Biomaterials, 2008, 29: 3561-3573
[66] Iwamoto Y, Yamakoshi Y. Chem. Commun., 2006, 4805-4807
[67] Mroz P, Pawlak A, Satti M, Lee H, Wharton T, Gali H, Sarna T, Hamblin M R. Free Radic. Biol. Med., 2007, 43: 711-719
[68] 江贵长(Jiang G C). 华中科技大学博士学位论文(Doctoral Dissertation of Huazhong University of Science and Technology). 2005
[69] Rancan F, Helmreich M, Mölich A. Bioconjug. Chem., 2007, 18: 1078-1086
[70] Robinson J T, Tabakman S M, Liang Y, Wang H, Casalonque H S, Vinh D, Dai H. J. Am. Chem. Soc., 2011, 133: 6825-6831
[71] Yang K, Zhang S, Zhang G X, Sun X, Lee S T, Liu Z. Nano Lett., 2010, 10: 3318-3323
[72] Huang P, Xu C, Lin J, Wang C, Zhang C, Zhou X, Guo S, Cui D. Theranostics, 2011, 1: 240-250
[73] Dong H Q, Zhao Z L, Wen H Y, Li Y Y, Guo F F, Shen A J, Pilger F, Lin C, Shi D L. Sci. China Chem., 2010, 53: 2265-2271
[74] Chen C, Xing G, Wang J, Zhao Y, Li B, Tang J, Jia G, Wang T, Sun J, Xing L, Yuan H, Gao Y, Meng H, Chen Z, Zhao F, Chai Z, Fang X. Nano Lett., 2005, 5: 2050-2057
[75] Yin J J, Lao F, Meng J, Fu P P, Zhao Y, Xing G, Gao X, Sun B, Wang P C, Chen C, Liang X J. Mol. Pharmacol., 2008, 74: 1132-1140
[76] Zhou G, Li Y, Liu Y, Ge C, Sun B, Li B, Gao Y, Chen C. J. Nanosci. Nanotechnol., 2010, 10: 8597-8602
[77] Liang X J, Meng H, Wang Y Z, He H, Meng J, Lu J, Wang P C, Zhao Y, Gao X, Sun B, Chen C, Xing G, Shen D, Gottesman M M, Wu Y, Yin J J, Jia L. Proc. Nati. Acad. Sci. USA, 2010, 107: 7449-7454
[78] Friedman S H, Dellmp D L, Sijbesma R P, Sradanov G, Wudl F, Kenyon G L. J. Am. Chem. Soc., 1993, 115: 6505-6509
[79] 马万顺(Ma W S), 崔燕(Cui Y), 赵玉云(Zhao Y Y), 郑文富(Zheng W F), 张伟(Zhang W), 蒋兴宇(Jiang X Y), 张文杰(Zhang W J). 生物物理学报(Acta Biophysica Sinica), 2010, 26: 638-648
[80] 姚璐(Yao L), 宋高广(Song G G), 黄成(Huang C), 杨新林(Yang X L). 高等学校化学学报(Chemical Journal of Chinese Universitys), 2011, 44: 885-890
[81] 王志洁(Wang Z J), 曲雪菊(Qu X J), 汪艳(Wang Y), 陈宝平(Chen B P), 雷瑶(Lei Y). 中华现代中西医杂志(Chinese Journal of Current Traditional and Western Medicine), 2006, 4: 961-967
[82] Hu W, Peng C, Luo W, Lv M, Li X, Li D, Huang Q, Fan C. ACS Nano, 2010, 4: 4317-4323
[83] Akhavan O, Ghaderi E. ACS Nano, 2010, 4: 5731-5736
[84] 王存嫦(Wang C C), 阳明辉(Yang M H), 鲁亚霜(Lu Y S), 吴国强(Wu G Q), 沈国励(Shen G L), 俞汝勤(Yu R Q). 化学学报(Acta Chimica Sinica), 2006, 13: 1355-1360
[85] 尹峰(Yin F), 赵紫霞(Zhai Z X), 吴宝艳(Wu B Y), 王新胜(Wang X S), 王艳艳(Wang Y Y), 陈强(Chen Q). 分析化学(Chinese Journal of Analytical Chemistry), 2007, 7: 1021-1024
[86] Erlanger B F, Chen B X, Zhu M, Brus L. Nano Lett., 2001, 1: 465-467
[87] 周娜(Zhou N), 杨涛(Yang T), 焦奎(Jiao K), 宋彩霞(Song C X). 分析化学(Chinese Journal of Analytical Chemistry), 2010, 3: 301-306
[88] 史娟兰(Shi J L), 汪庆祥(Wang Q X), 陈建平(Chen J P), 郑梅霞(Zheng M X), 高飞(Gao F). 化学学报(Acta Chimica Sinica), 2011, 69: 2015-2020
[89] 李美仙(Li M X), 李铮(Li Z), 王放放(Wang F F), 朱志伟(Zhu Z W), 李南强(Li N Q), 顾镇南(Gu Z N), 周锡煌(Zhou X H). 分析化学(Chinese Journal of Analytical Chemistry), 2005, 33: 1211-1214
[90] Mohanty N, Berry V. Nano Lett., 2008, 8: 4469-4476
[91] Tang Z W, Wu H, Cort Z R, Buchko G W, Zhang Y Y, Shao Y Y, Aksay I A, Liu J, Lin Y. Small, 2010, 6: 1205-1209
[92] 刘坤平(Liu K P). 兰州大学博士学位论文(Doctoral Dissertation of Lanzhou University), 2011
[93] 李岩(Li Y), 唐点平(Tang D P). 福州大学学报(自然科学版)(Journal of Fuzhou University (Natural Science Edition), 2011, 5: 781-785
[94] 叶兵(Ye B), 梁戈玉(Liang G Y), 尹立红(Yin L H), 浦跃朴(Pu Y P). 癌变 ·畸变 ·突变(Carcino genesis, Terato Genesis&Muta genesis), 2009, 1: 6-9
[95] Warheit D B, Laurence B R, Reed K L, Roach D H, Reynolds A M, Webb T R. Toxicol. Sci., 2004, 77: 117-125
[96] Lam C W, James J T, Mccluskey R, Hunter R L. Toxicol. Sci., 2004, 77: 126-134
[97] Liu D D, Yi C Q, Zhang D W, Zhang J C, Yang M S. ACS Nano, 2010, 4: 2185-2195
[98] Zhang D W, Yi C Q, Qi S J, Yao X S, Yang M S. Methods Mol. Biol., 2010, 625: 41-53
[99] Li X M, Liu H F, Niu X F, Yu B, Fan Y, Feng Q, Cui F Z, Watari F. Biomaterials, 2012, 33: 4818-4827
[100] Cui D, Tian F, Ozkan C S, Wang M, Gao H. Toxicol. Lett., 2005, 15(155): 73-85.
[101] Wang J X, Chen C Y, Li B, Yu H, Zhao Y, Sun J, Li Y, Xing G, Yuan H, Tang J, Chen Z, Meng H, Gao Y, Ye C, Chai Z, Zhu C, Ma B, Fang X, Wan L. Biochem. Pharmacol., 2006, 71: 872-881
[102] 朱小山(Zhu X S), 朱琳(Zhu L), 郎宇鹏(Lang Y P), 李燕(Li Y), 端正花(Duan Z H), 姚琨(Yao K). 环境科学(Environmental Science), 2008, 29(4): 855-861
[103] Zhang W D, Sun B Y, Zhang L Z, Zhao B, Nie G, Zhao Y. Nanoscale, 2011, 3: 2636-2641
[104] Zhang X Y, Yin J L, Peng C, Hu W Q, Zhu Z Y, Li W X, Fan C, Huang Q. Carbon, 2011, 49: 986-995
[105] Zhang Y B, Ali S F, Dervishi E, Xu Y, Li Z, Casciano D, Biris A S. ACS Nano, 2010, 4: 3181-3186
[106] Lu C H, Zhu C L, Li J, Liu J J, Chen X, Yang H H. Chem. Commun., 2010: 3116-3118
[107] Ruiz O N, Fernando K A S, Wang B, Brown N A, Luo P G, McNamara N D, Vangsness M, Sun Y P, Bunker C E. ACS Nano, 2011, 5: 8100-8107
[108] Schrand A M, Huang H, Carlson J J, Schlager J J, Omacr Sawa E, Hussain S M, Dai L. J. Phys. Chem. B, 2007, 111: 2-7
[109] Schrand A M, Dai L M, Schlager J J, Hussain S M, Osawa E. Diamond Relat. Mater., 2007, 16: 2118-2123
/
| 〈 |
|
〉 |
PDF
(1329KB)
