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细胞内活性小分子近红外荧光成像探针
Near-Infrared Fluorescence Imaging Probes for Intracellular Reactive Small Molecules
近年来,随着生命科学的不断发展,人们对细胞内活性小分子在病理、生理等方面的功能研究越来越深入。荧光成像作为一种直观、原位的可视化观测技术在小分子检测方面得到了广泛应用,其中基于近红外分子与纳米探针的荧光成像技术因具有背景干扰低、对细胞损伤小、样品穿透性强、检测灵敏度高等优点,显示了较好的应用前景。本文评述了近年来近红外荧光探针用于细胞内活性小分子成像检测的应用及进展,主要讨论该类方法在活性氧物质、金属离子、H+、阴离子及巯基化合物的分析应用,并对该方法的应用前景进行了展望。
With the development of life sciences, a lot of energy has been put into the research on the pathological and physiological functions of intracellular reactive small molecules (RSMs). As an efficient technique suitable for visualization in vivo, confocal fluorescence imaging has been applied to the monitor of RSMs in biological samples. The near-infrared fluorescence imaging based on molecular probes and nano probes has shown attractive and extensive application prospect in virtue of low background, less cell photodamage, deeper penetration of tissue, and relatively high sensitivity. This review summarizes the recent progress on near-infrared fluorescent probes for cellular RSMs, of which reactive oxygen species, metal ions, H+, anion ions, and thiols are mainly introduced. Particularly, future study and prospect are envisioned. Contents
1 Introduction
2 Near-infrared fluorescent probes for reactive oxygen species
3 Near-infrared fluorescent probes for metal ions
4 Near-infrared fluorescent probes for pH
5 Near-infrared fluorescent probes for anion ions
6 Near-infrared fluorescent probes for thiols
7 Conclusion and outlook
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