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基于磁性氧化铁纳米粒的诊断治疗药物
Magnetic Iron Oxide Nanoparticle-Based Theranostic Nanomedicine
诊断治疗药物作为一种新兴的治疗策略,展现出良好的应用前景。基于磁性氧化铁纳米粒的诊断治疗药物利用纳米技术将纳米粒与治疗性药物同时装载于纳米粒上,该纳米系统一般由三部分组成:磁性纳米粒核心、包覆层及功能区域。该系统可以用于影像诊断、实时监测药物输送、进行药效评价,并有望用于个体化医疗。本文介绍了磁性氧化铁纳米粒的合成、表面修饰、功能化及其生物医学应用等,重点介绍了磁性氧化铁纳米粒的表面修饰及功能化,经过表面修饰及功能化后,可制得多模式化、多功能化的诊断治疗药物,并对纳米诊断治疗药物在应用于个体化医疗所面临的挑战进行了初步的分析讨论。
Theranostic nanomedicine is emerging as a promising therapeutic strategy. Magnetic iron oxide nanoparticle-based theranostic nanomedicine takes advantage of nanotechnology to load both nanoparticle and therapeutic agent into one nanoparticle. The resulting nanosystem is composed of three main components: an iron oxide nanoparticle core, coating, and multifunction moieties. These nanoparticles are expected to play a significant role in personalized medicine for their capability of diagnosis, visualizing drug delivering and monitoring therapeutic response in real-time. In this review, we summarize the synthesis, surface modification, multifunction and biomedicine application of magnetic iron oxide nanoparticle, especially focused on the part of surface modification and multifunction, which are associated with the multimodality and multifunctionality theranostics. At last, the challenges of the application of nanomedicine in personalized medicine are presented.
Contents
1 Introduction
2 Synthesis of MNPs
3 The compounds commonly used in the surface modification of MNPs
3.1 Polymers
3.2 Inorganic shells
3.3 Small organic molecules
4 Surface functionalization of MNPs
4.1 Targeting modification of MNPs
4.2 Multifunction of MNPs
5 Application of theranostic nanomedicine based on MNPs
6 Challenge of theranostic nanomedicine in clinic
诊断治疗药物
theranostic nanomedicine
[1] Xie J, Lee S, Chen X. Adv. Drug Deliv. Rev., 2010, 62(11): 1064-1079
[2] Kelkar S S, Reineke T M. Bioconjug. Chem., 2011, 22(10): 1879-1903
[3] Nie S, Xing Y, Kim G J, Simons J W. Annu. Rev. Biomed. Eng., 2007, 9: 257-288
[4] Fang C, Zhang M. J. Control Release, 2010, 146(1): 2-5
[5] Mahmoudi M, Sant S, Wang B, Laurent S, Sen T. Adv. Drug Deliv. Rev., 2011, 63(1/2): 24-46
[6] Lin M M, Kim H H, Kim H, Dobson J, Kim D K. Nanomedicine, 2010, 5(1): 109-133
[7] Sun C, Lee J S, Zhang M. Adv. Drug Deliv. Rev., 2008, 60(11): 1252-1265
[8] Andreas K, Georgieva R, Ladwig M, Mueller S, Notter M, Sittinger M, Ringe J. Biomaterials, 2012, 33(18): 4515-4525
[9] Jain T K, Richey J, Strand M, Leslie-Pelecky D L, Flask C A, Labhasetwar V. Biomaterials, 2008, 29(29): 4012-4021
[10] Kim D K, Mikhaylova M, Zhang Y, Muhammed M. Chem. Mat., 2003, 15(8): 1617-1627
[11] Ramaswamy S, Schornack P A, Smelko A G, Boronyak S M, Ivanova J, Mayer J E, Sacks M S. NMR Biomed., 2012, 25(3): 410-417
[12] Shubayev V I, Pisanic T R, Jin S. Adv. Drug Deliv. Rev., 2009, 61(6): 467-477
[13] Lammers T, Kiessling F, Hennink W E, Storm G. Mol. Pharm., 2010, 7(6): 1899-1912
[14] Chen X Y, Gambhlr S S, Cheon J. Accounts Chem. Res., 2011, 44(10): 841-841
[15] Wu J H, Ko S P, Liu H L, Jung M H, Lee J H, Ju J S, Kim Y K. Colloid. Surf. A-Physicochem. Eng. Asp., 2008, 313/314: 268-272
[16] Chin A B, Yaacob I I. J. Mater. Process. Technol., 2007, 191(1/3): 235-237
[17] Goti Dc＇ M, Jurkin T, Musi Dc＇ S. Colloid Poly. Sci., 2007, 285(7): 793-800
[18] Vasylenko I V, Kolotilov S V, Kotenko I E, Gavrilenko K S, Tuna F, Timco G A, Winpenny R E P, Pavlishchuk V V. J. Magn. Magn. Mater., 2012, 324(4): 595-601
[19] Simeonidis K, Mourdikoudis S, Moulla M, Tsiaoussis I, Martinez-Boubeta C, Angelakeris M, Dendrinou-Samara C, Kalogirou O. J. Magn. Magn. Mater., 2007, 316(2): e1-e4
[20] Chen R F, Cheng J H, Wei Y. J. Alloy. Compd., 2012, 520: 266-271
[21] Tadi Dc＇ M, Kusigerski V, Markovi Dc＇ D, Panjan M, Miloševi Dc＇ I, Spasojevi Dc＇ V. J. Alloy. Compd., 2012, 525: 28-33
[22] Marchegiani G, Imperatori P, Mari A, Pilloni L, Chiolerio A, Allia P, Tiberto P, Suber L. Ultrason. Sonochem., 2012, 19(4): 877-882
[23] Cabrera L, Gutierrez S, Menendez N, Morales M P, Heffasti P. Electrochim. Acta, 2008, 53(8): 3436-3441
[24] Ma Z, Liu H. China Particuology, 2007, 5(1/2): 1-10
[25] Berry C C, Wells S, Charles S, Aitchison G, Curtis A S. Biomaterials, 2004, 25(23): 5405-5413
[26] Fang M, Strom V, Olsson R T, Belova L, Rao K V. Nanotechnology, 2012, 23(14): art. no. 145601
[27] Shi R R, Gao G H, Yi R, Zhou K C, Qiu G Z, Liu X H. Chin. J. Chem., 2009, 27(4): 739-744
[28] Amara D, Felner I, Nowik I, Margel S. Colloid Surf. A- Physicochem. Eng. Asp., 2009, 339(1/3): 106-110
[29] Sun S H, Zeng H. J. Am. Chem. Soc., 2002, 124(28): 8204-8205
[30] Xie J, Chen K, Huang J, Lee S, Wang J H, Gao J, Li X G, Chen X Y. Biomaterials, 2010, 31(11): 3016-3022
[31] Xie J, Liu G, Eden H S, Ai H, Chen X Y. Accounts Chem. Res., 2011, 44(10): 883-892
[32] Jun Y W, Lee J H, Cheon J. Angew. Chem. Int. Ed. Engl., 2008, 47(28): 5122-5135
[33] Gupta A K, Gupta M. Biomaterials, 2005, 26(18): 3995-4021
[34] Rosen J E, Chan L, Shieh D B, Gu F X. Nanomedicine, 2012, 8(3): 275-290
[35] Gupta A K, Curtis A S G. J. Mater. Sci. Mater. Med., 2004, 15(4): 493-496
[36] Erathodiyil N, Ying J Y. Acc. Chem. Res., 2011, 44(10): 925-935
[37] Flesch C, Unterfinger Y, Bourgeat-Lami E, Duguet E, Delaite C, Dumas P. Macromol. Rapid Commun., 2005, 26(18): 1494-1498
[38] Zheng Y, Gao S, Ying J Y. Adv. Mater., 2007, 19(3): 376-380
[39] Jiwon L, Tetsuhioko I, Mamoru S. J. Colloid Interface Sci., 1996, 177: 490- 494
[40] Liu S, Wei X, Chu M, Peng J, Xu Y. Colloids Surf. B-Biointerfaces, 2006, 51(2): 101-106
[41] Garcia I, Tercjak A, Zafeiropoulos N E, Stamm M, Mondragon I. J. Polym. Sci. Pol. Chem., 2007, 45(20): 4744-4750
[42] Hickey R J, Haynes A S, Kikkawa J M, Park S J. J. Am. Chem. Soc., 2011, 133(5): 1517-1525
[43] Berry C C, Wells S, Charles S, Aitchison G, Curtis A S. Biomaterials, 2004, 25(23): 5405-5413
[44] Cho J H, Ko S G, Ahn Y, Choi E J. J. Magn., 2009, 14(3): 124-128
[45] Sun C R, Du K, Fang C, Bhattarai N, Veiseh O, Kievit F, Stephen Z, Lee D H, Ellenbogen R G, Ratner B, Zhang M Q. ACS Nano, 2010, 4(4): 2402-2410
[46] Chung H J, Lee H, Bae K H, Lee Y, Park J, Cho S W, Hwang J Y, Park H, Langer R, Anderson D, Park T G. ACS Nano, 2011, 5(6): 4329-4336
[47] Lu Z, Dai J, Song X, Wang G, Yang W. Colloid Surf. A-Physicochem. Eng. Asp., 2008, 317(1/3): 450-456
[48] Xu Z Z, Wang C C, Yang W L, Fu S K. J. Mater. Sci., 2005, 40(17): 4667-4669
[49] Hui C, Shen C M, Tian J F, Bao L H, Ding H, Li C, Tian Y A, Shi X Z, Gao H J. Nanoscale, 2011, 3(2): 701-705
[50] Lu Y, Yin Y D, Mayers B T, Xia Y N. Nano Lett., 2002, 2(3): 183-186
[51] Li Y T, Liu J, Zhong Y J, Zhang J, Wang Z Y, Wang L, An Y L, Lin M, Gao Z Q, Zhang D S. Int. J. Nanomed., 2011, 6: 2805-2819
[52] Xu Z C, Hou Y L, Sun S H. J. Am. Chem. Soc., 2007, 129(28): 8698-8699
[53] Kumagai M, Sarma T K, Cabral H, Kaida S, Sekino M, Herlambang N, Osada K, Kano M R, Nishiyama N, Kataoka K. Macromol. Rapid Commun., 2010, 31(17): 1521-1528
[54] Lyon J L, Fleming D A, Stone M B, Schiffer P, Williams M E. Nano Lett., 2004, 4(4): 719-723
[55] Tamer U, Gündo Dgˇ du Y, Boyací H, Pekmez K. J. Nanopart. Res., 2009, 12(4): 1187-1196
[56] Cui Y R, Hong C, Zhou Y L, Li Y, Gao X M, Zhang X. Talanta, 2011, 85(3): 1246-1252
[57] De Palma R, Peeters S, van Bael M J, van den Rul H, Bonroy K, Laureyn W, Mullens J, Borghs G, Maes G. Chem. Mat., 2007, 19(7): 1821-1831
[58] ampelj S, Makovec D, Drofenik M. J. Magn. Magn. Mater., 2009, 321: 1346-1350
[59] Tassa C, Shaw S Y, Weissleder R. Acc. Chem. Res., 2011, 44(10): 842-852
[60] Koo H, Huh M S, Sun I C, Yuk S H, Choi K, Kim K, Kwon I C. Acc. Chem. Res., 2011, 44(10): 1018-1028
[61] Ling Y, Wei K, Luo Y, Gao X, Zhong S Z. Biomaterials, 2011, 32(29): 7139-7150
[62] Yang X Q, Hong H, Grailer J J, Rowland I J, Javadi A, Hurley S A, Xiao Y L, Yang Y A, Zhang Y, Nickles R, Cai W B, Steeber D A. Biomaterials, 2011, 32(17): 4151-4160
[63] Wunderbaldinger P, Josephson L, Weissleder R. Bioconjug. Chem., 2002, 13(2): 264-268
[64] Gupta A K, Naregalkar R R, Vaidya V D, Gupta M. Nanomedicine, 2007, 2(1): 23-39
[65] Xie H, Zhu Y H, Jiang W L, Zhou Q, Yang H, Gu N, Zhang Y, Xu H B, Yang X L. Biomaterials, 2011, 32(2): 495-502
[66] Fei X N, Liu L J, Zhu S, Liu Y R. Prog. Chem., 2011, 23(8): 1728-1736
[67] Yu M K, Park J, Jon S. Theranostics, 2012, 2: 3-44
[68] Kommareddy S, Amiji M. Bioconjugate Chem., 2005, 16(6): 1423-1432
[69] Sun E Y, Josephson L, Kelly K A, Weissleder R. Bioconjug. Chem., 2006, 17(1): 109-113
[70] McCarthy J R, Weissleder R. Adv. Drug Deliv. Rev., 2008, 60(11): 1241-1251
[71] Reddy G R, Bhojani M S, McConville P, Moody J, Moffat B A, Hall D E, Kim G, Koo Y E, Woolliscroft M J, Sugai J V, Johnson T D, Philbert M A, Kopelman R, Rehemtulla A, Ross B D. Clin. Cancer Res., 2006, 12(22): 6677-6686
[72] Mok H, Veiseh O, Fang C, Kievit F M, Wang F Y, Park J O, Zhang M Q. Mol. Pharm., 2010, 7(6): 1930-1939
[73] Yu M K, Park J, Jeong Y Y, Moon W K, Jon S. Nanotechnology, 2010, 21(41): art. no. 415102
[74] Veiseh O, Sun C, Fang C, Bhattarai N, Gunn J, Kievit F, Du K, Pullar B, Lee D, Ellenbogen R G, Olson J, Zhang M. Cancer Res., 2009, 69(15): 6200-6207
[75] Hadjipanayis C G, Machaidze R, Kaluzova M, Wang L, Schuette A J, Chen H, Wu X, Mao H. Cancer Res., 2010, 70(15): 6303-6312
[76] Ge Y, Zhang Y, He S, Nie F, Teng G, Gu N. Nanoscale Res. Lett., 2009, 4(4): 287-295
[77] Kumar M, Yigit M, Dai G, Moore A, Medarova Z. Cancer Res., 2010, 70(19): 7553-7561
[78] Brunel F M, Lewis J D, Destito G, Steinmetz N F, Manchester M, Stuhlmann H, Dawson P E. Nano Lett., 2010, 10(3): 1093-1097
[79] Zhang J, Misra R D. Acta Biomater., 2007, 3(6): 838-850
[80] Kolb H C, Finn M G, Sharpless K B. Angew. Chem. Int. Edit., 2001, 40 (11): 2004-2021
[81] Sun E Y, Josephson L, Weissleder R. Mol. Imaging, 2006, 5(2): 122-128
[82] Das M, Bandyopadhyay D, Mishra D, Datir S, Dhak P, Jain S, Maiti T K, Basak A, Pramanik P. Bioconjug. Chem., 2011, 22(6): 1181-1193
[83] Santra S, Kaittanis C, Grimm J, Perez J M. Small, 2009, 5(16): 1862-1868
[84] Chen G H, Chen W J, Wu Z, Yuan R X, Li H, Gao J M, Shuai X T. Biomaterials, 2009, 30: 1962-1970
[85] Jain T K, Morales M A, Sahoo S K, Leslie-Pelecky D L, Labhasetwar V. Mol. Pharm., 2005, 2(3): 194-205
[86] Ling Y, Wei K, Luo Y, Gao X, Zhong S Z. Biomaterials, 2011, 32: 7139-7150
[87] El-Dakdouki M H, Zhu D C, El-Boubbou K, Kamat M, Chen J, Li W, Huang X. Biomacromolecules, 2012, 13(4): 1144-1151
[88] Medarova Z, Pham W, Farrar C, Petkova V, Moore A. Nat. Med., 2007, 13(3): 372-377
[89] Medarova Z, Rashkovetsky L, Pantazopoulos P, Moore A. Cancer Res., 2009, 69(3): 1182-1189
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