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无机药物: 问题和解决思路
Update of Metal-Based Drugs: Problems and Approaches for Solution
进入本世纪以来,无机药物及相关基础研究获得巨大的发展,同时也面临着巨大的困难。本文综述了两类金属药物——抗癌金属药物和抗糖尿病钒化合物的研究进展和目前存在的严重瓶颈问题,并提出未来发展应重视下列方面:(1)发现新的金属药物分子机制,在此基础上实现理性药物设计;(2)基于分子机理实现对金属药物毒性的控制;(3)理性设计和建立基于纳米、分子复合物和药物分子转运体的新的金属药物转运体系;(4)发展金属配合物的合成生物学。
From this century, great progresses have been made in the field of metal-based medicine and relevant fundamental researches. However, there are also major problems left to be solved. This review summarized the recent progresses and the bottlenecks of two important metal drugs, anti-cancer platinum/non-platinum drugs and anti-diabetic vanadium compounds. The following aspects are proposed for attentions in the future research: (1) Discover new molecular mechanism of metal drugs for rational design of metal drugs; (2) Control of metal toxicity based on molecular mechanism; (3) Rational metal drug design and metal drug delivery system based on nano materials, molecular complexes and drug transporters; (4) Synthetic biology of metal complexes.
Contents
1 Introduction
2 Anti-cancer compounds
2.1 Drug resistance of cisplatin
2.2 Rational drug design
2.3 Improve bioavailability through drug design and targeted delivery
2.4 Novel anti-cancer strategy: poisoning cell vs prisoning cell
3 Anti-diabetic vanadium compounds
3.1 Mechanisms of pharmacological actions and rational drug design
3.2 Toxicity of vanadium compounds
3.3 Pharmacokinetics of vanadium compounds
4 Conclusions and outlook
anti-cancer
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