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稀土手性配合物在核酸识别及调控方面的研究
Recent Progress on Molecular Recognition and Modulation of Nucleic Acids Using Chiral Rare-Earth Complexes
通过小分子选择性靶向特殊基因,进而调节该基因所参与的生物学功能一直是生物无机化学领域十分活跃的研究课题。其中,DNA的手性识别引起了人们的高度重视,因为越来越多的研究表明,DNA的手性转化以及DNA构象的多样性与一系列重要的生命过程密切相关。此外,DNA的手性识别对于药物的合成以及DNA构象探针的设计也非常重要。在过去的几十年里,人们合成了大量的手性小分子和金属配合物,能够对B-DNA,Z-DNA以及G-四链DNA表现出特异性识别。由于独特的4fn的电子结构,稀土配合物已经广泛地应用于生物荧光探针以及磁共振成像。另外,作为人工核酸酶,稀土配合物表现出高效的促进DNA和RNA的水解能力,并且不会造成氧化损伤。近年来,人们正努力发现能够选择性靶向DNA进而调制DNA性质的稀土手性配合物,并已经取得了显著的成果。本文总结了目前关于稀土手性配合物对核酸的手性识别及选择性调控等方面的研究进展。
There is great interest in design and synthesis of small molecules which selectively target specific genes to inhibit biological functions. Among these studies, chiral DNA recognition has been received much attention because more evidences have shown that conversions of the chirality and diverse conformations of DNA are involved in a series of important life events. In addition, chiral molecular recognition of DNA is important for rational drug design and developing structural probes of DNA conformation. Over the past few decades, considerable attention has focused on the design of DNA binding chiral agents, especially B-DNA, Z-DNA and G-quadruplex DNA binding agents. Rare-earth compounds, due to a unique 4fn electronic configuration, have been widely used as probes in luminescent resonance energy transfer for bioassays and as reagents for diagnosis in magnetic resonance imaging. As chemical nucleases, rare-earth complexes have also shown a high efficiency to hydrolyze DNA and RNA without redox chemistry. Recently, there is great interest in the design and synthesis of chiral rare-earth complexes which selectively target specific DNA. Excitedly, some interesting results have been reported. This review summarizes the current progress in chiral rare-earth complexes binding to nucleic acids and their chiral selectivity.
Contents
1 Introduction
2 Synthesis of rare-earth chiral compounds
3 Recognition of rare-earth chiral compounds to duplex DNA
4 Recognition of rare-earth chiral compounds to single strand DNA and quadruplex DNA
5 Perspective
rare earths
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