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人血清白蛋白及其复合物的结构基础
Structural Basis of Human Serum Albumin and Its Complexes
人血清白蛋白是人体中一种最丰富的血浆蛋白质,是主要的脂肪酸和外源性分子如药物等的转运载体。由于大多数药物需要结合白蛋白被运输到靶组织和器官,白蛋白对于药物的代谢动力学和递送起到关键作用。40多年来,白蛋白与小分子化合物的相互作用一直是国内、外的研究热点。此外,白蛋白作为药物载体被广泛地研究和应用。因此,本文将从蛋白质结构层面上综述白蛋白和白蛋白复合物的相关知识,提出白蛋白相关研究领域的一些未来挑战。
Human serum albumin is the most abundant protein in plasma and one of the major binders/carriers of fatty acid and drugs, plays an essential role in pharmacokinetics and delivery of drugs for it transports a wide variety of drugs to target organs and tissues. In the past forty years, the interaction between albumin and compounds is research hotspots both at home and abroad. Furthermore, human serum albumin has been extensively studied as drug carrier. Therefore, this paper first reviews the knowledge on structure of human serum albumin and its complexes, and then puts forward some future challenges on human serum albumin field.
Contents
1 Introduction
2 Structural basis of human serum albumin
2.1 Overall structure of human serum albumin
2.2 Sub-domain structure of human serum albumin
2.3 Cysteine-34 of human serum albumin
3 Structural basis of human serumalbumin-fatty acids
3.1 Binding site of fatty acids at human serum albumin
3.2 Influence of fatty acids on conformation of human serum albumin
4 Structural basis of human serum albumin-drug
4.1 Site Ⅰ
4.2 Site Ⅱ
5 Conclusions and outlook
人血清白蛋白
human serum albumin
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