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转化医学研究中的生物无机化学问题探讨
The Study of Biological Inorganic Chemistry Problemsin Translational Medicine
转化医学是进入21世纪以来国际生物医学及健康领域出现的新概念。它是基础研究到临床应用的双向过程,是临床实践与基础研究之间的循环式的研究体系, 它不是一门新的学科,只是强调一种理念,是特定时代背景的产物。目前, 转化医学研究主要涉及以下领域:肿瘤、心脑血管疾病、代谢疾病、精神疾病、运动系统疾病、遗传病、器官移植、组织工程、疾病诊断、药物研发、个体化治疗、干细胞研究、动物模型研究以及免疫学等。本文综述了在疾病诊断、组织工程领域、个体化治疗、新药研发以及发病机制中涉及到的生物无机化学问题。最后, 展望了该新领域今后的发展方向和亟待研究的重要问题。
Translational medicine is an emerging concept in the fields of biomedical research and healthcare since twenty-first century. It is a two-way process from the basic research to clinical application with direct feedbacks in between. It is not a new subject, but emphasizes a concept. It stems from an unmet need in clinical medicine. At present, translational medical research is mainly involved in the following areas: cancer, cardiovascular diseases, metabolic disorders, psychiatric disorders, diseases of the locomotor system, genetic diseases, organ transplantation, tissue engineering, disease diagnosis, drug research and development, personalized therapy, stem cell research, animal model studies and immunology etc. This article reviews the bioinorganic chemistry problems involved in the disease diagnosis, tissue engineering, individual therapy, drug research and development and disease mechanisms. Finally, the development of this new area and important issues to be studied are outlooked.Contents
1 The bioinorganic chemistry problems in disease diagnosis
1.1 New diagnosis methods
1.2 Imaging technology
2 The bioinorganic chemistry problems in tissue engineering
3 The bioinorganic chemistry problems in individual therapy
4 The bioinorganic chemistry problems in drug research and development
4.1 From single-target drug design to systematic intervention
4.2 Emerging nanomedicine
5 The bioinorganic chemistry problems in molecular mechanisms of diseases
5.1 The relationship between metal homeostasis and neurodegenerative diseases
5.2 The relationship between oxygen (nitrogen) homeostasis and neurodegenerative diseases
6 Outlook
转化医学
translational medicine
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