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纳米颗粒在抗癌药物可控靶向释放中的应用

张磊, 刘晓燕, 沈晶晶, 卢晓梅, 范曲立*, 黄维*

化学进展 ›› 2013, Vol. 25 ›› Issue (08) :1375-1382

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化学进展 ›› 2013, Vol. 25 ›› Issue (08) :1375-1382 DOI: 10.7536/PC121205
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纳米颗粒在抗癌药物可控靶向释放中的应用

    张磊, 刘晓燕, 沈晶晶, 卢晓梅, 范曲立*, 黄维*
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Application of Nanoparticles with Targeting, Triggered Release in Anti-Cancer Drug Delivery

  • Zhang Lei, Liu Xiaoyan, Shen Jingjing, Lu Xiaomei, Fan Quli*, Huang Wei*
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文章历史 +

摘要

近些年来癌症发病率不断攀升,引起了人们的普遍关注。由于传统诊疗方法存在弊端,因此开发新型的针对肿瘤组织的多功能的纳米颗粒(如金纳米颗粒、脂质体、聚合物、DNA等)药物输送系统越来越重要。基于生物体的EPR效应或经过表面修饰功能化后,纳米颗粒输送系统可被动或主动靶向到达肿瘤组织,并通过控制温度、pH、超声、光以及酶等激发条件在肿瘤区域实现可控释放。本文简单介绍了肿瘤治疗中常用的具有靶向性、可控释放的纳米颗粒载药系统,系统地描述了纳米颗粒在药物输送系统的最新研究进展,并对今后的发展方向作了展望。

Abstract

In recent years, the higher incidence of cancer has aroused wide public concern. Due to the drawbacks of conventional cancer treatment methods, there has been increasing interest in developing new drug targeting delivery systems with multi-functionalized nanoparticles, such as gold nanoparticles, liposomes, polymers, DNA, etc. Base on the enhanced permeability and retention (EPR) effect, the nanoparticles can present both passive and active targeting mechanisms after modified with the targeting biomoleculars on the surface. And the temperature, pH, ultrasound, light and enzymes can all act as incentives for triggered release in tumor regions. This review examines functionalities engineered into nanoparticles recently, including targeting and triggered release of contents, and these properties have raised new opportunities for drug delivery system. Contents
1 Introduction
2 The nanoparticles for anti-cancer drug delivery system
3 The application of nanoparticles with triggered release
3.1 Heat trigger
3.2 Light trigger
3.3 pH trigger
3.4 Ultrasound trigger
3.5 Enzymatic trigger
4 Conclusion and outlook

关键词

纳米颗粒 / 药物输送系统 / 靶向 / 可控释放

Key words

nanoparticles / drug delivery system / targeting / triggered release

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引用格式 ▾
张磊, 刘晓燕, 沈晶晶, 卢晓梅, 范曲立, 黄维. 纳米颗粒在抗癌药物可控靶向释放中的应用[J]. 化学进展, 2013, 25(08): 1375-1382 DOI:10.7536/PC121205
Zhang Lei, Liu Xiaoyan, Shen Jingjing, Lu Xiaomei, Fan Quli, Huang Wei. Application of Nanoparticles with Targeting, Triggered Release in Anti-Cancer Drug Delivery[J]. Progress in Chemistry, 2013, 25(08): 1375-1382 DOI:10.7536/PC121205

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