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芳(杂)环甾体化合物的合成及生理活性研究

崔建国, 刘亮, 甘春芳, 肖琦, 黄燕敏*

化学进展 ›› 2014, Vol. 26 ›› Issue (0203) :320-333

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化学进展 ›› 2014, Vol. 26 ›› Issue (0203) :320-333 DOI: 10.7536/PC130652
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芳(杂)环甾体化合物的合成及生理活性研究

    崔建国, 刘亮, 甘春芳, 肖琦, 黄燕敏*
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Synthesis and Biological Activity of Steroids Bearing Aromatic Rings and Heterocycles

  • Cui Jianguo, Liu Liang, Gan Chunfang, Xiao Qi, Huang Yanmin*
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摘要

芳(杂)环甾体化合物是一类具有显著生理活性的化合物,它们往往具有很好的抗菌、抗炎和抗肿瘤活性。本文根据此类化合物的结构类型进行分类,讨论近年来芳(杂)环甾体化合物的合成及生物活性研究进展,并对其发展趋势和应用前景进行了展望。

Abstract

Steroids bearing aromatic rings and heterocycles are types of compounds with significant physiological activities. Generally, they possess a good antibacterial, anti-inflammatory and anti-tumor activity. In this paper, the synthesis and biological activity of steroids bearing aromatic rings and heterocycles in recent year are reviewed according to the classification of their structures, such as steroidal heterocycles bonded A-ring, fused A-ring, bonded B-ring, bonded D-ring, etc. Their developing trends and applying prospects are also expected.

Contents
1 Steroids bearing aromatic rings and heterocycles bonded A-ring
2 Steroids bearing aromatic rings and heterocycles fused A-ring
3 Steroids bearing aromatic rings and heterocycles bonded B-ring
4 Steroids bearing aromatic rings and heterocycles bonded D-ring
4.1 Steroids bearing aromatic rings and heterocycles bonded 17-C
4.2 Steroids bearing aromatic rings and heterocycles bonded 16-C
5 Steroids bearing aromatic rings and heterocycles fused D-ring
6 Outlook

关键词

芳(杂)环甾体化合物 / 生物活性 / 抗肿瘤活性

Key words

steroids bearing aromatic ring and heterocycle / biological activity / anti-tumor activity

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引用格式 ▾
崔建国, 刘亮, 甘春芳, 肖琦, 黄燕敏. 芳(杂)环甾体化合物的合成及生理活性研究[J]. 化学进展, 2014, 26(0203): 320-333 DOI:10.7536/PC130652
Cui Jianguo, Liu Liang, Gan Chunfang, Xiao Qi, Huang Yanmin. Synthesis and Biological Activity of Steroids Bearing Aromatic Rings and Heterocycles[J]. Progress in Chemistry, 2014, 26(0203): 320-333 DOI:10.7536/PC130652

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