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食用植物成分和中药用于癌症化学预防：Nrf2,表观基因组学,癌症干细胞
苏正元, 舒利民, Jong Hun Lee, Franciso Fuentes, 王虎, 吴天元, 余四旺, Ah-Ng Tony Kong
化学进展 ›› 2013, Vol. 25 ›› Issue (09) :1526-1543
食用植物成分和中药用于癌症化学预防：Nrf2,表观基因组学,癌症干细胞
苏正元, 舒利民, Jong Hun Lee, Franciso Fuentes, 王虎, 吴天元, 余四旺, Ah-Ng Tony Kong
化学进展 ›› 2013, Vol. 25 ›› Issue (09) :1526-1543
食用植物成分和中药用于癌症化学预防：Nrf2,表观基因组学,癌症干细胞
Perspective on Nrf2, Epigenomics and Cancer Stem Cells in Cancer Chemoprevention Using Dietary Phytochemicals and Traditional Chinese Medicines
癌症是世界范围内的首要致死原因之一。现代诊断和治疗技术的革新改善了癌症患者的治疗和护理,但晚期癌症的治疗仍然是一个巨大的挑战。因此,亟需新的创造性的策略来防治癌症。几个世纪以来,草药曾被用于防治癌症等疾病。科研资助机构,例如美国的国家癌症研究所(NCI),在近期加强了对利用天然植物成分和非毒性药物如非甾体抗炎药(NSAIDs)预防或减缓癌症发生研究的支持。本文综述了利用来源于蔬果、绿茶和中药的生物活性成分来预防癌症方面的研究,尤其是重点讨论了在Nrf2、表观基因组学和癌症干细胞等方面的影响。
Cancer is one of the leading causes of death worldwide. The innovation of modern diagnostics and chemotherapeutics has improved cancer patients' treatment and care, but advanced stages of cancer remain extremely challenging to treat. Therefore, new and creative approaches are needed to prevent and treat cancer. Herbal medicines have been used for many centuries to prevent diseases such as cancer. Funding agencies, such as the National Cancer Institute in the United States, have recently emphasized support for cancer chemoprevention research using natural phytochemicals and non-toxic drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent or delay the onset of cancer. This perspective distills the latest in cancer chemoprevention research using bioactive components from fruits, vegetables, green tea and Traditional Chinese Medicines (TCM), focusing on Nrf2, epigenomic and cancer stem cell effects.
癌症化学预防
cancer chemoprevention
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