中文 |
English |
Email Alert
甲基丙烯酰乙基磺基甜菜碱类聚合物的生物应用
许利娜1, 马培培1, 陈强1,2,3, 林思聪1, 沈健*1,3
化学进展 ›› 2014, Vol. 26 ›› Issue (0203) :366-374
甲基丙烯酰乙基磺基甜菜碱类聚合物的生物应用
许利娜1, 马培培1, 陈强1,2,3, 林思聪1, 沈健*1,3
化学进展 ›› 2014, Vol. 26 ›› Issue (0203) :366-374
甲基丙烯酰乙基磺基甜菜碱类聚合物的生物应用
Biological Application of Sulfobetaine Methacrylate Polymers
两性离子聚合物具有阴阳离子基团，能够高度水化，具有优异的生物相容性。甲基丙烯酰乙基磺基甜菜碱（SBMA）聚合物因其独特的两性离子链结构，具有抗蛋白质污染、抗细菌黏附及抗凝血等抗生物污染性能，这种特性使其在生物医学等相关领域得到越来越多的应用。本文介绍了其抗生物污染的水化理论，对甲基丙烯酰乙基磺基甜菜碱类聚合物的结构、性质、合成方法及表面构建方法等作了概述和分析，对其在人造器官材料、组织工程、生物分离、生物监测、温度敏感材料等方面的应用作了重点介绍，并分析了目前应用存在的问题和潜在的应用前景。
Zwitterionic polymers have anion and cation groups simultaneously, which make them highly hydrated and render them unique biocompatibility. Because of their unique zwitterionic pendant-side chain structures, sulfobetaine methacrylate (SBMA) polymers present the excellent anti-biofouling properties, i.e. the resistance to protein adsorption, the inhibition of bacterial and blood coagulation, which make them increasingly applied in a wide range of biological and medical related fields recently. The hydration theory, one of the widely accepted antifouling mechanisms, is briefly introduced. In this article, recent progress in the properties, synthesis methods and surface construction methods is reviewed, the applications of SBMA polymers in the materials for artificial organs, tissue engineering, biological separation, bio-monitoring system and temperature-sensitive materials are summarized. In addition, SBMA polymers holding great potential for use in biomaterials and issues existed in these applications are also discussed.
Contents
1 Introduction
2 Mechanism investigation of biocompatibility
3 Preparation of SBMA polymers and methods of immobilization of SBMA polymers onto the materials
4 Application of SBMA polymers
4.1 Application of SBMA polymers in the materials for artificial organs
4.2 Application of SBMA polymers in the tissue engineering
4.3 Application of SBMA polymers in the biological separation
4.4 Application of SBMA polymers in the bio-monitoring system
4.5 PSBMA used for temperature-sensitive materials
4.6 Others
5 Conclusion and perspective
biomaterials
[1] Sun T L, Qing G Y, Su B L, Jiang L. Chem. Soc. Rev., 2011, 40: 2909.
[2] Jiang S, Cao Z. Adv. Mater., 2010, 22(9): 920.
[3] Salamone J C, Volksen W, lsrael S C, Olson A P, Raia D C. Polymer, 1977, 18: 1058.
[4] Cardoso J, Manero O. J. Polym. Sci., Part B: Polym. Phys., 1991, 29: 639.
[5] Lee W F, Tsai C C. Polymer, 1995, 36: 357.
[6] Williams D F, Biomaterials, 2008, 29: 2941.
[7] 林思聪(Ling S C). 高分子通报(Polym. Bull.), 1998, 1(1): 1.
[8] 何淑漫(He S M), 周健(Zhou J). 化学进展(Progress in Chemistry), 2010, 22(4): 760.
[9] Ishihara K, Nomura H, Mihara T, Kurita K, Iwasaki Y, Nakabayashi N. J. Biomed. Mater. Res., 1998, 39: 323.
[10] Tanaka M, Mochizuki A. J. Biomater. Sci. Polym. Ed., 2010, 21: 1849.
[11] Suzawa T, Shirahama H. Adv. Colloid. Interface. Sci., 1991, 35: 139.
[12] Chen H, Yuan L, Song W, Wu Z K, Li Dan. Prog. Polym. Sci., 2008, 33: 1059.
[13] Wang Y X, Robertson L J, Spillman Jr B W, Claus O R. Pharm. Res., 2004, 21: 1362.
[14] Chen M, Briscoe W H, Armes S P, Klein J. Science, 2009, 323: 1698.
[15] Fang F, Igal S. Biophys. J., 2001, 80: 2568.
[16] Kitano H, Kawasaki A, Kawasaki H, Morokoshi S. J. Colloid Interf. Sci., 2005, 282: 340.
[17] Wei J H, Yoshinari M, Takemoto S, Hattori M, Kawada E, Liu B L, Oda Y. J. Biomed. Mater. Res. B, 2007, 81: 66.
[18] Estephan Z G, Schlenoff P S, Schlenoff J B. Langmuir, 2011, 27: 6794.
[19] 何晓燕(He X Y), 周文瑞(Zhou W R), 徐晓君(Xu X J), 杨武(Yang W). 化学进展(Progress in Chemistry), 2013, 25(6): 1023.
[20] Heath D E, Cooper S L. Acta Biomater., 2012, 8: 2899.
[21] 丁伟(Ding W), 毛程(Mao C), 韦兆水(Wei Z S), 李明(Li M), 于涛(Yu T), 曲广淼(Qu G M). 应用化学(Chinese Journal of Applied Chemistry), 2011, 28(5): 555.
[22] Bütün V. Polymer, 2003, 44: 7321.
[23] Zhao Y H, Wee K H, Bai R. ACS Appl. Mater. Inter., 2010, 2: 203.
[24] Zhang Z, Finlay J A, Wang L F, Gao Y, Callow J A, Callow M E, Jiang S Y. Langmuir, 2009, 25: 13516.
[25] Dai F Y, Liu W Q. Biomaterials, 2011, 32: 628.
[26] 刘红艳(Liu H Y), 周健(Zhou J). 化学进展(Progress in Chemistry), 2012, 24(11): 2187.
[27] Yuan B, Chen Q, Ding W Q, Liu P S, Wu S S, Lin S C, Shen J, Gai Y. ACS Appl. Mater. Interfaces, 2012, 4: 4031.
[28] Liu P S, Chen Q, Wu S S, Shen J, Lin S C. J. Membrane Sci., 2010, 350: 387.
[29] 马佳妮(Ma J N), 宫铭(Gong M), 杨珊(Yang S), 张世平(Zhang S P), 宫永宽(Gong Y K). 化学进展(Progress in Chemistry), 2008, 20(07/08): 1151.
[30] Chang Y, Chen W Y, Yandi W, Shi Y J, Chu W L, Liu Y L, Chu C W, Ruaan R C, Higuchi A. Biomacromolecules, 2007, 8: 122.
[31] Kuo W H, Wang M J, Chien H W, Wei T C, Lee C, Tsai W B. Biomacromolecules, 2011, 12: 4348.
[32] Ye S H, Johnson Jr A C, Woolley R J, Murata H, Gamble J L, Ishihara K, Wagner R W. Colloids Surf. B Biointerfaces, 2010, 79: 357.
[33] Kuang J H, Messersmith P B. Langmuir, 2012, 28: 7258.
[34] Thomson J A, Itskovitz-Eldor J, Shapiro S S, Waknitz M A, Swiergiel J S, Marshall V S, Jones J M. Science, 1998, 282: 1145.
[35] Shamblott M J, Axelman J, Wang S P, Bugg E M, Littlefield J W, Donovan P J, Blumenthal P D, Huggins G R, Gearhart J D. Proc. Natl. Acad. Sci. U. S. A., 1998, 95: 13726.
[36] Villa-Diaz L G, Brown S E, Liu Y, Ross A M, Lahann J, Parent J M, Krebsbach P H. Stem Cells, 2012, 30: 1174.
[37] Villa-Diaz G L, Nandivada H, Ding J, Nogueira-de-Souza C N, Krebsbach H P, O'Shea S K, Lahann J, Smith D G. Nat. Biotechnol., 2010, 28: 581.
[38] 刘红艳(Liu H Y), 周健(Zhou J). 化工进展(Chemical Industry and Engineering Progress), 2012, 24(11): 2187.
[39] Yang Y F, Li Y, Li Q L, Wan L S, Xu Z K. J. Membrane Sci., 2010, 362: 255.
[40] 杨更亮(Yang G L), 刘海燕(Liu H Y). 中国科学: 化学(Scientia Sinica Chimica), 2010, 40(6): 631.
[41] Gritti F, Guiochon G. J. Chromatogr. A, 2012, 1228: 2.
[42] Lin H, Ou J J, Zhang Z B, Dong J, Wu M H, Zou H F. Anal. Chem., 2012, 84: 2721.
[43] Wang X C, Ding K, Yang C M, Lin X C, Lü H X, Wu X P, Xie Z H. Electrophoresis, 2010, 31: 2997.
[44] Sanghavi B J, Mobin S M, Mathur P, Lahiri G K, Srivastava A K. Biosens. Bioelectron., 2013, 39: 124.
[45] Marguet M, Bonduelle C, Lecommandoux S. Chem. Soc. Rev., 2013, 42: 512.
[46] Qian T, Yu C F, Wu S S, Shen J. Biosens. Bioelectron., 2013, 50: 157.
[47] Karman S B, Diah S Z M, Gebeshuber I C. Sensors, 2012, 12: 14232.
[48] Angenendt P, Glökler J, Sobek J, Lehrach H, Cahill J D. J. Chromatogr. A, 2003, 1009: 97.
[49] Rebeski D E, Winger E M, Shin Y K, Lelenta M, Robinson M M, Varecka R, Crowther J R. J. Immunol. Methods, 1999, 226: 85.
[50] Qian T, Yu C F, Wu S S, Shen J. Colloids Surf., B, 2013, 112: 310.
[51] Seurynck-Servoss S L, White A M, Baird C L, Rodland K D, Zangar R C. Anal. Biochem., 2007, 371: 105.
[52 ] Nguyen T A, Baggerman J, Paulusse M J J, Zuilhof H, van Rijn C J M. Langmuir, 2012, 28: 604.
[53] 喻晓莉(Yu X L), 杨健(Yang J), 倪彦(Yan Y). 自动化技术与应用(Techniques of Automation & Applications), 2009, 28(2): 107.
[54] Sakai Y, Sadaoka Y, Matsuguchi M. Sens. Actuators B, 1996, 85: 35.
[55] Sakai Y, Matsuguchi M, Hurukawa T. Sens. Actuators B, 2000, 66: 135.
[56] Lee M H, Rhee H W, Gong M S. Sens. Actuators B, 2001, 73: 124.
[57] Lee C W, Rhee H W, Gong M S. Synth. Met., 1999, 106: 177.
[58] Su P G, Uen C L. Sens. Actuators B, 2005, 107: 317.
[59] Li Y, Yang M J. Sens. Actuators B, 2002, 87: 184.
[60] Han D S, Gong M S. Sens. Actuators B, 2010, 145: 254.
[61] Han D S, Gong M S. Macromol. Res., 2010, 18: 260.
[62] Chang Y, Yandi W, Chen W Y, Shih Y J, Yang C C, Chang Y, Ling Q D, Higuchi A. Biomacromolecules, 2010, 11: 1101.
[63] Polzer F, Heigl J, Schneider C, Ballauff M, Borisov V O. Macromolecules, 2011, 44: 1654.
[64] Costerton J W, Cheng K J, Geesey G G, Ladd T I, Nickel J C, Dasgupta M, Marrie I T. Annu. Rev. Microbiol., 1987, 41: 435.
[65] Cheng G, Zhang Z, Chen S, Bryers J D, Jiang S Y. Biomaterials, 2007, 28: 4192.
[66] Bargman M J. Semin. Dialysis, 2012, 25: 668.
[67] Leblanc M, Ouimet D, Pichette V. Semin. Dialysis, 2001, 14: 50.
[68] Li M, Neoh K G, Xu L Q, Wang R, Kang E T, Lau T, Olszyna D P, Chiong E. Langmuir, 2012, 28: 16408.
[69] Zhang Z, Finlay J A, Wang L F, Gao Y, Callow J A, Callow M E, Jiang S Y. Langmuir, 2009, 25: 13516.
/
| 〈 |
|
〉 |
PDF
(2073KB)
