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DNA折纸术纳米反应器
DNA Origami Nanoreactors
基于DNA折纸技术，构建具有纳米尺度可寻址的新型DNA纳米反应器，是DNA纳米技术领域的一个最新研究思路和方向。它的优势首先在于其纳米定位能力，通过不同的化学或生物相互作用，已能够实现对包括化学小分子、生物大分子及人工纳米材料等的纳米级精确定位；其次，DNA折纸结构的丰富多样性，使构建纳米级仿生限域环境成为了可能；此外，DNA折纸结构本身的生物相容性及优良的产率，也保证了这一材料的可应用性。本文首先介绍了在DNA折纸结构上，对不同材料和分子进行纳米定位的一般方法和最新进展。然后，着重阐述了基于纳米定位技术，以DNA折纸结构作为纳米反应器，对一些化学、生化反应的成功调控。最后，基于现有的工作基础，我们提出了DNA折纸术纳米反应器概念在未来的发展方向及应用前景展望。
It is a new idea to construct DNA nanoreactor with nanometer addressability using DNA origami technology. One of the most remarkable features of the DNA origami method is the precise addressability of the structures formed. By biologically and chemically modifying specific staple strands, it is possible to functionalize DNA origami nanostructures with small chemical molecules, biomacromolecules and artificial nanomaterials on well-defined positions with nanoscale precision. The shape diversity and good biological compatibility of DNA origami makes it a perfect nanomaterial for constructing nanoscale biomimetic confinement environment. In this review, we first introduce the general method and the latest progress for nano-addressable positioning of different materials and molecules on DNA origami nanostructures. Then utilizing DNA origami nanostructures as nano-addressable reactors with confined nanoscale spaces, we focus on the regulation of chemical and biochemical reactions in these nanoreactors. At the end, the future directions and potential applications of DNA origami nanoreactors are foreseen.
Contents
1 Introduction
2 Nano-addressable positioning on DNA origami nanostructures
2.1 Positioning of functional groups
2.2 Positioning of biomacromolecules
2.3 Positioning of synthetic nanomaterials
3 Regulation of single molecular chemical reactions
3.1 Cleavage reactions
3.2 Coupling reactions
3.3 Polymerization reactions
4 Regulation of single molecular bio-recognitions and biochemical reactions
4.1 Molecular recognitions
4.2 Enzymatic cascade reactions
5 Conclusion and outlook
DNA折纸术
DNA origami
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