生物法与化学法制备硫酸软骨素

石玉刚; 党亚丽; 刘玉华; 白雪

doi:10.7536/PC140312

化学进展 ›› 2014, Vol. 26 ›› Issue (08) :1378-1394 DOI: 10.7536/PC140312

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生物法与化学法制备硫酸软骨素

^1,2

作者信息 +

Microbial and Chemical Production of Chondroitin Sulfate

Shi Yugang*^1,2, Dang Yali³, Liu Yuhua¹, Bai Xue¹

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文章历史 +

摘要

硫酸软骨素（ChS）是一种天然的酸性黏多糖，生物活性多样，在医学、生物、制药、食品、化妆品和材料等领域均有广泛应用，特别是在治愈骨关节病上具有颇为理想的效果。本文系统地总结了有关硫酸软骨素及其类似物的生物与化学制备方法的研究进展，如高产微生物菌株筛选与改良，培养条件优化与调控，汇聚式合成策略构建，经济易得的起始物原料等，并指出制备硫酸软骨素中存在的问题以及发展方向。

Abstract

Chondroitin sulfates (ChS) are a complex polysaccharide having important structural and protective functions and play important roles in many biological processes. It has been widely applied in a variety of fields, such as medicine, biotechnology, pharmacy, food, cosmetics and textiles. This mini-review focuses on the recent advances in microbial and chemical synthesis of such molecules. The productive strains, fermentation conditions, convergent strategies, use of new starting materials, and syntheses of all the ChS variant oligosaccharides are discussed. In addition, suggestions for further studies in syntheses of ChS are proposed based on current research.

Contents
1 Introduction
2 Biotechnological production of ChS and ChS-like products
2.1 Enzymatic synthesis of ChS and ChS-like products
2.2 Microbial production of ChS and ChS-like products
3 Chemical synthesis of ChS and ChS-like products
4 Conclusion and outlook

Graphical abstract

关键词

硫酸软骨素 / 化学合成 / 生物催化 / 硫酸化代码

Key words

chondroitin sulfate / chemical synthesis / enzymatic synthesis / sulfo code

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石玉刚, 党亚丽, 刘玉华, 白雪. 生物法与化学法制备硫酸软骨素[J]. 化学进展, 2014, 26(08): 1378-1394 DOI:10.7536/PC140312

Shi Yugang, Dang Yali, Liu Yuhua, Bai Xue. Microbial and Chemical Production of Chondroitin Sulfate[J]. Progress in Chemistry, 2014, 26(08): 1378-1394 DOI:10.7536/PC140312

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