基于SERS探针技术的细胞识别、成像与诊疗

宋春元; 陈文蔷; 杨琰君; 杨博玥; 苏邵; 汪联辉

doi:10.7536/PC140738

化学进展 ›› 2015, Vol. 27 ›› Issue (1) :91-102 DOI: 10.7536/PC140738

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基于SERS探针技术的细胞识别、成像与诊疗

宋春元*, 陈文蔷, 杨琰君, 杨博玥, 苏邵, 汪联辉*

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Surface-Enhanced Raman Scattering Tags Used in Cell Recognition, Imaging, Diagnosis and Treatment

Song Chunyuan*, Chen Wenqiang, Yang Yanjun, Yang Boyue, Su Shao, Wang Lianhui*

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文章历史 +

摘要

表面增强拉曼散射(surface-enhanced Raman scattering, SERS),是指吸附在粗糙的金属纳米结构表面的被分析物,在光照射下其拉曼光谱获得显著增强的异常表面光学现象。近年来,SERS技术已广泛地用于物质检测和生物传感等研究,在生物医学领域表现出巨大的应用潜力并取得了令人瞩目的研究成果。本文回顾了SERS探针技术在细胞识别、成像与诊疗等方面的应用及最新研究进展,重点介绍了SERS细胞探针的构建方法与原理,以及基于SERS探针的细胞检测应用策略,并讨论了SERS探针技术在细胞检测中仍有待解决的关键问题。

Abstract

Surface-enhanced Raman scattering (SERS) refers to an abnormal surface optical phenomenon that Raman spectra of the analyte adsorbed on metal nanostructures can be significantly enhanced under laser irradiation. In recent years, SERS has been widely used in the substance detection and biological sensing, which has achieved significant development and shown great potential applications in the biomedical field. In this paper, the preparation principle and the latest development of SERS tags used in cell detection are introduced, and their recent applications in cell recognition, imaging, diagnosis and treatment are reviewed, as well as the detection strategies and issues related to SERS tag-based cell detection are discussed.

Contents
1 Introduction
2 SERS tags
2.1 Noble metal nanoparticles
2.2 Raman reporter molecules
2.3 Surface coating for protection
2.4 Biofunction with biomolecules
3 Application of SERS tags in cell
3.1 Cell recognition
3.2 Cell imaging
3.3 Cell pH sensing
3.4 Cancer diagnosis and treatment
4 Conclusions and outlooks

Graphical abstract

关键词

表面增强拉曼散射 / SERS探针 / 细胞识别 / 成像 / 诊疗

Key words

surface-enhanced Raman scattering / SERS tag / cell recognition / imaging / diagnosis and treatment

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宋春元, 陈文蔷, 杨琰君, 杨博玥, 苏邵, 汪联辉. 基于SERS探针技术的细胞识别、成像与诊疗[J]. 化学进展, 2015, 27(1): 91-102 DOI:10.7536/PC140738

Song Chunyuan, Chen Wenqiang, Yang Yanjun, Yang Boyue, Su Shao, Wang Lianhui. Surface-Enhanced Raman Scattering Tags Used in Cell Recognition, Imaging, Diagnosis and Treatment[J]. Progress in Chemistry, 2015, 27(1): 91-102 DOI:10.7536/PC140738

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