中文 |
English |
Email Alert
纳米羟基磷灰石/聚合物复合骨修复材料
Nano-Hydroxyapatite/Polymer Composite as Bone Repair Materials
寻找理想的骨修复材料一直是骨科材料领域研究热点。自然骨是由纳米羟基磷灰石和胶原构成的纳米复合材料。源于仿天然硬组织构想的纳米磷灰石-有机高分子复合材料是把高韧性的高分子基质与高刚性的纳米无机磷灰石晶体巧妙结合,使其最大程度地实现两种成分的优势互补和协同优化,赋予仿生纳米复合材料高强韧的力学性能。与组成同样重要的是结构因素,这种材料包括不同尺寸的架构组织和可控取向。纳米羟基磷灰石/高分子复合材料已成为骨组织修复材料领域的研究热点和发展方向。本文综述了近些年用于人体骨组织修复材料的纳米羟基磷灰石/天然(或非天然)高分子材料的制备技术、性能等方面研究进展及现状,并对其发展提出了展望。
The searching of ideal bone repair materials has always been one of research hot spots in the field of orthopedics. Natural bones are nanocomposites mainly composed of nano-hydroxyapatite and collagen. Nano-hydroxyapatite/polymer composites, derived from imitation of natural hard tissue, combine polymer matrix with high toughness and nano-hydroxyapatite crystals with high rigidity. These nanocomposites have high toughness since they maximize the complementary advantages. Structure factors are equally important to composition for the high performance of these composites, which include architectural organization and controlled orientation in different dimensions. Nano-hydroxyapatite/polymer composite materials have become a research hot spot and development direction in the field of bone tissue repair materials. This paper summarizes the research progress and status in the aspects of preparation and properties of these materials used for the repair of body hard tissue, and predicts its future development.
Contents
1 Introduction
2 Nano-hydroxyapatite/natural polymer composites
2.1 Nano-hydroxyapatite/collagen composite
2.2 Nano-hydroxyapatite/silk fibroin composite
2.3 Nano-hydroxyapatite/chitosan composite
3 Nano-hydroxyapatite/synthetic polymer composites
3.1 Nano-hydroxyapatite/polylactic acid composite
3.2 Nano-hydroxyapatite/polyamide composite
3.3 Nano-hydroxyapatite/polyethylene composite
3.4 Nano-hydroxyapatite/other polymer composites
4 Conclusion and outlooks
nano-hydroxyapatite
[1] Dorozhkin S V. Materials, 2009, 2(2): 399.
[2] Stevens M M, George J H. Science, 2005, 310(5751): 1135.
[3] 左奕(Zuo Y), 李玉宝(Li Y B). 东南大学学报(医学版)(J. Southest Univ.(Medical Science Edition)), 2011, 30(1): 82.
[4] Tan J, Saltzman W M, Biomaterials, 2004, 25(17): 3593.
[5] Iyyappan E, Wilson P. Ceram. Int., 2013, 39(1): 771.
[6] Chaudhry A A, Yan H, Gong K, Inam F, Viola G, Reece M J, Goodall J B M, ur Rehman I, McNeil-Watson F K, Corbett J C W, Knowles J C, Darr J A. Acta Biomater., 2011,7(2): 791.
[7] Devis B, Antonella S, Matteo G, Federica C, Valeria C. Mater. Sci. Eng., 2013, 33(1): 1091.
[8] Jamuna-Thevi K, Daud N M, Kadir M R A, Hermawan H. Ceram. Int., 2014, 40(1): 1001.
[9] Kikuchi M, Itoh S, Ichinose S, Shinomiya K, Tanaka J. Biomaterials, 2001, 22(13): 1705.
[10] 张超(Zhang C), 胡蕴玉(Hu Y Y), 吕荣(Lv R), 徐建强(Xu J Q). 中华实验外科杂志(Chin. Exp. Surg.), 2002, 19(5): 458.
[11] 王振林(Wang Z L), 闫玉华(Yan Y H), 万涛(Wan T). 复合材料学报(Acta Materiae Compositae Sinica), 2005, 22(2): 83.
[12] Liao S S, Cui F Z, Zhang W, Feng Q L. J. Biomed. Mater. Res. Part B, 2004, 69(2): 158.
[13] Liao S S, Cui F Z, Zhu Y. J. Bioact. Comp. Polym., 2004, 19(2): 117.
[14] 林晓艳(Lin X Y), 范红松(Fan H S), 李旭东(Li X D), 唐敏(Tang M), 张伶利(Zhang L L),谭言飞(Tan Y F), 徐金瑞(Xu J R), 张兴栋(Zhang X D). 中国生物医学工程学报(Chinese Journal of Biomedical Engineering), 2006, 25(1): 63.
[15] Cunniffe G M, Dickson G R, Partap S, Stanton K T, O'Brien F J. J. Mater. Sci. Mater. Med., 2010, 21(8): 2293.
[16] Xia Z, Yu X, Jiang X, Brody H D, Rowe D W, Wei M. Acta Biomater., 2013, 9(7): 7308.
[17] Aminova R M, Galiullina L F, Silkin N I, Ulmetov A R, Klochkov V V, Aganov A V. J. Mol. Struct., 2013, 1049: 13.
[18] Libonati F, Nair A K, Vergani L, Buehler M J. Mech. Res. Commun., 2014, 58: 17.
[19] Fan H, Liu H, Toh S L, Goh J C H. Biomaterials, 2009, 30(28): 4967.
[20] 王刚(Wang G), 姚金波(Yao J B), 周旭光(Zhou X G), 盛楠(Sheng N). 复合材料学报(Acta Materiae Compositae Sinica), 2008, 26(6): 136.
[21] Fan C, Li J, Xu G, He H, Ye X, Chen Y, Sheng X, Fu J, He D. J. Mater. Sci., 2010, 45(21): 5814.
[22] Kim H J, Kim U J, Kim H S, Li C, Wada M, Leisk G G, Kaplan D L. Bone, 2008, 42( 6): 1226.
[23] Kino R, Ikoma T, Monkawa A, Yunoki S, Munekata M, Tanaka J, Asakura T. J. Appl. Polym. Sci., 2006, 99(5): 2822.
[24] Kino R, Ikoma T, Yunoki S, Monkawa A, Matsuda A, Kagata G, Asakura T, Munekata M, Tanaka J. Key Eng. Mater., 2006, 309: 1169.
[25] 姜法兴(Jiang F X). 硕士论文(Master Dissertation),西南交通大学(XiNan JiaoTong University), 2008.
[26] Yang T L. Int. J. Mol. Sci., 2011, 12(3): 1936.
[27] Jayakumar R, Prabaharan M, Kumar P T S, Nair S V, Tamura H. Biotechnol. Adv., 2011, 29(3): 322.
[28] Lu G Y, Zhu L, Kong L J, Zhang L, Gong Y D, Zhao N M, Zhang X F.Tsinghua Science & Technology, 2006, 11(4): 427.
[29] 张利(Zhang L), 李玉宝(Li Y B), 魏杰(Wei J), 左奕(Zuo Y), 韩纪梅(Han J M), 吴兰(Wu L), 王学江(Wang X J). 功能材料(Journal of Functional Materials), 2005, 36(3): 441.
[30] 孙珍珍(Sun Z Z), 蔡汝汝(Cai R R), 蒲曦鸣(Pu X M), 杨云(Yang Y), 姚清清(Yao Q Q), 张其清(Zhang Q Q). 厦门大学学报(自然科学版)(Journal of Xiamen University)(Natural Science), 2010, 49(5): 671.
[31] Zhang J, Liu G, Wu Q, Zuo J, Qin Y, Wang J. J. Bionic. Eng., 2012, 9(2): 243.
[32] Reverchon E, Adami R. Powder Technol., 2013, 246: 441.
[33] Zhao H, Jin H, Cai J. Mater. Lett., 2014, 116: 293.
[34] Jin H H, Kim D H, Kim T W, Shin K K, Jung J S, Park H C, Yoon S Y. Int. J. Biol. Macromol., 2012, 51(5): 1079.
[35] Yu C C, Chang J J, Lee Y H, Lin Y C, Wu M H, Yang M C, Chien C T. Mater. Lett., 2013, 93: 133.
[36] Lasprilla A J R, Martinez G A R, Lunelli B H, Jardini A L, Maciel R. Biotechnol. Adv., 2012, 30(1): 321.
[37] 崔阳(Cui Y), 刘一(Liu Y), 黄威(Huang W). 中国组织工程研究与临床康复(Journal of Clinical Rehabilitative Tissue Engineering Research),2007,11(31): 6244.
[38] 汪学军(Wang X J), 宋国君(Song G J), 楼涛(Lou T), 彭文娟(Peng W J). 化工进展(Chemicial Industry and Engineering Progress), 2009, 28(4): 669.
[39] 杨春瑜(Yang C Y), 杨春莉(Yang C L), 田晓红(Tian X H), 柏树令(Bai S L),王淑静(Wang S J), 赫美(He M), 佟浩(Tong H). 西安交通大学学报(Journal of Xi'An JiaoTong University), 2010, 44(12): 114.
[40] Bae J Y, Won J E, Park J S, Lee H H, Kim H W. Mater. Lett., 2011, 65(19): 2951.
[41] Lian X, Liu H, Wang X, Xu S, Cui F, Bai X. Progress in Natural Science: Mater. Int., 2013, 23(6): 549.
[42] Wei J, Li Y, Lau K T. Compos. Part B: Eng., 2007, 38(3): 301.
[43] Zhang X, Li Y, Zuo Y, Lv G Y, Mu Y H, Li H. Compos. Part A: Appl. Sci. Manuf., 2007, 38(3): 843.
[44] Wang H, Li Y, Zuo Y, Li J, Ma S, Cheng L. Biomaterials, 2007, 28(22): 3338.
[45] 周银银(Zhou Y Y), 汪涛(Wang T), 陶杰(Tao J). 中国组织工程研究与临床康复(Journal of Clinical Rehabilitative Tissue Engineering Research), 2009, 13(38): 7455.
[46] 梁熙(Liang X), 蒋电明(Jiang D M), 倪卫东(Ni W D), 欧云生(Ou Y S), 周爱国(ZhoubA G), 于学东(Yu X D), 李玉宝(Li Y B).中国修复重建外科杂志(Chinese Journal of Reparative and Reconstructive Surgery), 2007, 21(8): 785.
[47] Li J, Man Y, Zuo Y, Zhang L, Huang C, Liu M, Li Y. J. Biomat. Sci.: Polym. Ed., 2011, 22(1/3): 263.
[48] Lim K L K, Mohd I Z A, Ishiaku U S, Fuad A M Y, Yusof A H, Czigany T, Pukanzsky B, Ogunniyi D S. J. Appl. Polym. Sci., 2006, 100(5): 3931.
[49] Gupta A, Tripathi G, Lahiri D, Balani K. J. Mater. Sci. Technol., 2013, 29(6): 514.
[50] Fouad H, Elleithy R, Alothman O Y. J. Mater. Sci. Technol., 2013, 29(6): 573.
[51] Deng M, Shalaby S W. Biomaterials, 1997, 18(9): 645.
[52] Wang M, Bonfield W. Biomaterials, 2001, 22(11): 1311.
[53] Fang L, Leng Y, Gao P. Biomaterials, 2006, 27(20): 3701.
[54] 张斌(Zhang B), 周科朝(Zhou K C), 黄苏萍(Huang S P), 朱武(Zhu W).中南大学学报(自然科学版) (J. Cent. South Univ.)(Science and Technology), 2008, 39(1): 23.
[55] 黄苏萍(Huang S P), 周科朝(Zhou K C). 高分子材料科学与工程(Polymer Materials Science and Engineering), 2010, 26(11): 147.
[56] Fouad H, Elleithy R, Alothman O Y. J. Mater. Sci. Technol., 2013, 29(6): 573.
[57] Rhee S H, Suetsugu Y, Tanaka J. Biomaterials, 2001, 22(21): 2843.
[58] Yan Y, Li Y, Yang Z, Zuo Y, Wei J, Cao X, Chen Y. Eur. Polym. J., 2003, 39(2): 411.
[59] Liao J, Zhang L, Zuo Y, Wang H, Li J, Zou Q, Li Y. J. Biomater. Appl., 2009, 24(7): 31.
[60] 蒋佳春(Jiang J C), 吕国玉(Lv G Y), 严永刚(Yan Y G), 伍登学(Wu D X), 刘少英(Liu S Y). 材料工程(Journal of Materials Engineering), 2013, (4): 56.
[61] Wang M, Yue C Y, Chua B. J. Mater. Sci.: Mater. Med., 2001, 12(9): 821.
[62] Robinson P Ⅱ, Wilson C Ⅱ, Mecholsky J Jr. J. Eur. Ceram. Soc., 2014, 34(5): 1387.
[63] Anderson D G, Burdick J A, Langer R. Science, 2004, 305(5692): 1923.
/
| 〈 |
|
〉 |
PDF
(6373KB)
