超顺磁性Fe3O4纳米粒子在磁共振造影中的应用

刘天辉; 常刚; 曹瑞军; 孟令杰

doi:10.7536/PC141042

化学进展 ›› 2015, Vol. 27 ›› Issue (5) :601-613 DOI: 10.7536/PC141042

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超顺磁性Fe₃O₄纳米粒子在磁共振造影中的应用

刘天辉, 常刚, 曹瑞军, 孟令杰*

作者信息 +

Applications of Superparamagnetic Fe₃O₄ Nanoparticles in Magnetic Resonance Imaging

Liu Tianhui, Chang Gang, Cao Ruijun, Meng Lingjie*

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文章历史 +

摘要

超顺磁性Fe₃O₄纳米粒子由于其廉价、低毒及超顺磁等特性,已成为重要的一类磁共振造影剂.本文综述了超顺磁性Fe₃O₄纳米粒子的可控制备方法,归纳总结影响粒径、结晶度和磁性能的主要因素和影响规律;为进一步提高磁性能并实现多功能,总结了Fe₃O₄纳米粒子进一步组装和表面改性的方法和机理;系统讨论了Fe₃O₄纳米粒子的形貌、尺寸和表面性能等对磁性能和生物相容性的影响规律;并指出了Fe₃O₄纳米粒子在磁共振造影领域潜在的发展方向和研究热点.

Abstract

Fe₃O₄ nanomaterials have attracted tremendous attention in the field of magnetic resonance imaging (MRI) because of their low cost, good biocompatibility, favorable superparamagnetic properties. This article focuses on the controlled preparation methods of superparamagnetic Fe₃O₄ nanoparticles, and provides an in-depth discussion of the key factors and their influence rules for particle size, crystallinity and magnetic properties. The current status of available methodologies and mechanisms for the assembly and surface modification of Fe₃O₄ nanoparticles are highlighted to generate high performance and multifunction. We also systematically summarize the effect of particle size, morphology and surface properties on the magnetic and toxic properties of Fe₃O₄ nanoparticles. Finally, the future opportunities and challenges of Fe₃O₄ nanomaterials used as MRI contrast agents are addressed to our understanding.

Contents
1 Introduction
2 Controllable preparation of Fe₃O₄ nanoparticles
2.1 Thermal decomposition
2.2 Coprecipitation
2.3 Solvothermal
2.4 Sol-gel
2.5 Microemulsion
2.6 Sonochemical
3 Assembly of Fe₃O₄ nanoparticles
3.1 Zero-dimensional sphere
3.2 One-dimensional nanochain
3.3 Multidimensional assembly
4 Surface functionalization of Fe₃O₄ nanoparticles
4.1 Modified by SiO₂
4.2 Modified by polymer
4.3 Multifunctional modification
5 Toxicity
6 MRI applications
6.1 Cell imaging
6.2 Tissue/organ imaging
7 Conclusion

Graphical abstract

关键词

Fe₃O₄ / 纳米材料 / 超顺磁 / 表面改性 / 磁共振成像

Key words

Fe₃O₄ / nanomaterials / superparamagnetic / surface modification / magnetic resonance imaging (MRI)

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刘天辉, 常刚, 曹瑞军, 孟令杰. 超顺磁性Fe₃O₄纳米粒子在磁共振造影中的应用[J]. 化学进展, 2015, 27(5): 601-613 DOI:10.7536/PC141042

Liu Tianhui, Chang Gang, Cao Ruijun, Meng Lingjie. Applications of Superparamagnetic Fe₃O₄ Nanoparticles in Magnetic Resonance Imaging[J]. Progress in Chemistry, 2015, 27(5): 601-613 DOI:10.7536/PC141042

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