新型纳米荧光探针在微流控细菌芯片检测中的应用

蒋艳; 徐溢; 王人杰; 苏喜; 董春燕

doi:10.7536/PC150132

化学进展 ›› 2015, Vol. 27 ›› Issue (9) :1240-1250 DOI: 10.7536/PC150132

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新型纳米荧光探针在微流控细菌芯片检测中的应用

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作者信息 +

Application of Novel Nano Fluorescent Probes for Bacteria Detection on the Microchip

Jiang Yan^1,3, Xu Yi^1,2,3*, Wang Renjie^1,3, Su Xi^1,3, Dong Chunyan¹

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文章历史 +

摘要

微流控芯片分析技术可以集成不同的生物化学分析功能单元,广泛应用于生化分析领域,在细菌检测方面具有传统检测方法不可比拟的优越性。近来年,在微流控细菌芯片中引入高荧光强度、低背景荧光干扰和高选择性的纳米荧光探针为实现细菌高效检测分析提供了新的研究途径和技术手段。本文通过对细菌检测中的几类新型荧光标记探针的介绍和比较,分析其荧光效应和应用特点,尤其是在细菌检测中的应用特性,重点综述了新型高效的纳米荧光探针与微流控细菌芯片分析方法和技术结合,实现微尺度空间和荧光检测模式下的细菌高效检测。

Abstract

Microfluidic system integrated with different functional units is widely employed in biochemical analysis and shows great potentials compared with conventional approaches for bacteria detection. Recently, novel nano fluorescent probes with improved fluorescent properties, low background and enhanced selectivity provide an efficient way for pathogenic bacteria quantitation, especially when they are combined with miniaturized platform or microfluidic device. Several novel nano fluorescent probes for bacteria detection are introduced and discussed in this review. Moreover, special attention has been paid to the recent research about combination of these approaches in bacteria analysis using variety of nano fluorescent probes on the microfluidic chip. It is also focused that the development of effective bacteria detection under the micro scale space with fluorescent monitoring mode.

Contents
1 Introduction
2 The technology of bacteria detection on microfluidic chips
3 New nano-fluorescent probes for bacteria labeled and detection
4 Detection of bacteria by nano-fluorescent probes on microfluidic chip
4.1 Detection of bacteria with nano-fluorescent probes
4.2 Detection of bacteria with nano-fluorescent probes and aptamers
4.3 Detection of bacteria with nano-fluorescent probes and immunoassay
5 Conclusion and perspective

Graphical abstract

关键词

纳米荧光探针 / 微流控芯片 / 细菌检测

Key words

nano fluorescent probes / microfluidic chip / bacteria detection

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蒋艳, 徐溢, 王人杰, 苏喜, 董春燕. 新型纳米荧光探针在微流控细菌芯片检测中的应用[J]. 化学进展, 2015, 27(9): 1240-1250 DOI:10.7536/PC150132

Jiang Yan, Xu Yi, Wang Renjie, Su Xi, Dong Chunyan. Application of Novel Nano Fluorescent Probes for Bacteria Detection on the Microchip[J]. Progress in Chemistry, 2015, 27(9): 1240-1250 DOI:10.7536/PC150132

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