多光谱光声层析成像及其在生物医学中的应用

刘迎亚; 范霄; 李艳艳; 渠陆陆; 覃海月; 曹英男; 李海涛

doi:10.7536/PC150348

化学进展 ›› 2015, Vol. 27 ›› Issue (10) :1459-1469 DOI: 10.7536/PC150348

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多光谱光声层析成像及其在生物医学中的应用

刘迎亚, 范霄, 李艳艳, 渠陆陆, 覃海月, 曹英男, 李海涛*

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Multispectral Photoacoustic Tomography and Its Development in Biomedical Application

Liu Yingya, Fan Xiao, Li Yanyan, Qu Lulu, Qin Haiyue, Cao Yingnan, Li Haitao*

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摘要

多光谱光声层析成像(MSOT)技术是一种将多光谱成像与光声层析成像(PACT)技术相结合的新技术,该技术利用不同生物组织的光谱吸收特性,用多组不同波长的短脉冲激光照射组织以产生组织特异性的光声信号,从而更好地进行光声成像和组分识别。MSOT兼具光学成像的高灵敏度、高分辨率优势和超声成像可对数厘米深组织成像的长处,同时又能弥补光学成像深度有限和超声成像对比度差的短处,能够实现深层组织的高分辨率、高对比度、高穿透深度的实时无损伤成像。迄今为止,MSOT已应用于肿瘤内光吸收粒子的检测、血管结构和血液氧合作用的评价、生物荧光蛋白的成像以及乳腺癌患者检测的初步研究。随着光声成像系统的不断改进,MSOT与生物标记物(如荧光试剂、金纳米颗粒等)结合对体内分子进行成像,在生物医学中得到了广泛的应用。本文简要综述了MOST的成像原理、实验装置及其性能特点,着重总结了其在生物医学领域的最新应用进展,尤其是在新生血管成像、肿瘤的早期诊断及肿瘤的原位成像方面。

Abstract

Multispectral photoacoustic tomography is one of the macroscopic observation methods combining multispectral imaging with photoacoustic computed tomography (PACT) technology. Based on the specific spectral absorption characteristics of different biological tissue, the technology illuminates the tissue with multiple sets of short pulse laser of different wavelengths to produce tissue-specific photoacoustic signal for better photoacoustic imaging and component identification. MSOT combines the high sensitivity and resolution of optical imaging with the ability of the several centimeters deep-tissue imaging by ultrasound imaging, while compensated for the depth limitation of optical imaging and the low contrast of ultrasound imaging. Thus it enables noninvasive real-time imaging in the deep tissue with high-resolution and high-contrast, large penetration depths. Over the last years, MSOT has been applied to detecting the light-absorbing particles within the tumor, evaluating vascular structures and blood oxygenation, imaging the biological fluorescent protein and preliminary studies on the breast cancer patients. With the continuous improvement of photoacoustic imaging system, multispectral photoacoustic imaging technology combined with biomarkers (such as fluorescent reagents, gold particles, etc.) has vast applications in biomedical field, especially to molecular imaging in vivo. In this paper, we gives a brief count of the imaging principle, experimental setup and the performance characteristics of MOST. Furthermore, we mainly summarizes the progress of its latest applications in the biomedical field, particularly in the angiogenesis imaging, early diagnosis of cancer and tumors in situ imaging.

Contents
1 Introduction
2 Photoacoustic imaging technology
2.1 Principle of operation
2.2 Classification of photoacoustic imaging
3 Multispectral photoacoustic tomography
3.1 MSOT experimental setup
3.2 Exogenous contrast agents
3.3 Performance characteristics
4 Advantages and challenges of MSOT
5 Applications of MSOT in biomedicine
5.1 Real-time monitoring of neovascularization
5.2 Early diagnosis of cancer
5.3 Targeting tumor imaging
6 Conclusion and outlook

Graphical abstract

关键词

多光谱 / 光声成像 / 层析术 / 生物医学应用

Key words

multispectral / photoacoustic imaging / tomography / biomedical application

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刘迎亚, 范霄, 李艳艳, 渠陆陆, 覃海月, 曹英男, 李海涛. 多光谱光声层析成像及其在生物医学中的应用[J]. 化学进展, 2015, 27(10): 1459-1469 DOI:10.7536/PC150348

Liu Yingya, Fan Xiao, Li Yanyan, Qu Lulu, Qin Haiyue, Cao Yingnan, Li Haitao. Multispectral Photoacoustic Tomography and Its Development in Biomedical Application[J]. Progress in Chemistry, 2015, 27(10): 1459-1469 DOI:10.7536/PC150348

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