生物铵转运蛋白对NH3/NH4+作用机理研究

张明明; 樊建芬; 于怡; 闫希亮; 许健

doi:10.7536/PC150429

化学进展 ›› 2015, Vol. 27 ›› Issue (11) :1658-1664 DOI: 10.7536/PC150429

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生物铵转运蛋白对NH₃/NH₄⁺作用机理研究

张明明, 樊建芬*, 于怡, 闫希亮, 许健

作者信息 +

Studying on the Mechanisms of NH₃/NH₄⁺through Ammonium Transport Proteins

Zhang Mingming, Fan Jianfen*, Yu Yi, Yan Xiliang, Xu Jian

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文章历史 +

摘要

铵转运蛋白广泛存在于细菌、真菌、植物以及动物等各种生命体中。生物铵转运蛋白对NH₃/NH₄⁺的传输作用已被广泛研究,然而,对于通过铵转运蛋白疏水性孔腔的物种是带电荷的NH₄⁺离子还是电中性的NH₃分子,仍存在很大争议。本文综述了近年来生物铵转运蛋白对NH₃/NH₄⁺作用机理的研究进展,主要包括NH₃或NH₄⁺的传输及NH₃和H⁺共传输等机理。

Abstract

Ammonium transport proteins widely exist in various life forms including bacteria, fungi, plants, animals, etc. The transport of NH₃/NH₄⁺ through an ammonium transport protein has been widely studied. However, the issue that the ionic NH₄⁺ or the electrically neutral NH₃ species truly goes through the hydrophobic pore of an ammonium transport protein remains controversial. This review surveys the progress in studying on the transport mechanisms of NH₃/NH₄⁺ through several typical ammonium transport proteins. The main mechanisms include the single transport of NH₃ or NH₄⁺, and the cooperative transport of NH₃ and H⁺, etc.

Contents
1 Introduction
2 NH₃ transport mechanism
3 NH₄⁺ transport mechanism
4 Cooperative transport of NH₃ and H⁺
5 Other transport mechanisms
6 Conclusion

Graphical abstract

关键词

铵转运蛋白 / NH₃/NH₄⁺跨膜传输 / 生物通道 / 作用机理

Key words

ammonium transport protein / NH₃/NH₄⁺ transmembrane transport / biological channel / mechanism

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张明明, 樊建芬, 于怡, 闫希亮, 许健. 生物铵转运蛋白对NH₃/NH₄⁺作用机理研究[J]. 化学进展, 2015, 27(11): 1658-1664 DOI:10.7536/PC150429

Zhang Mingming, Fan Jianfen, Yu Yi, Yan Xiliang, Xu Jian. Studying on the Mechanisms of NH₃/NH₄⁺through Ammonium Transport Proteins[J]. Progress in Chemistry, 2015, 27(11): 1658-1664 DOI:10.7536/PC150429

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