有序介孔二氧化硅纳米粒的制备及其肿瘤诊疗应用

曾峰; 潘真真; 张梦; 黄永焯; 崔彦娜; 徐勤

doi:10.7536/PC150437

化学进展 ›› 2015, Vol. 27 ›› Issue (10) :1356-1373 DOI: 10.7536/PC150437

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有序介孔二氧化硅纳米粒的制备及其肿瘤诊疗应用

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^1*

^2*

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Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor

Zeng Feng^1,2, Pan Zhenzhen^1,2, Zhang Meng¹, Huang Yongzhuo¹, Cui Yanna^1*, Xu Qin^2*

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摘要

有序介孔二氧化硅纳米粒由于具有独特的结构特征和物理化学性质,能够与磁性材料、荧光探针、抗肿瘤药物和特异性生物靶向分子等相结合,从而实现有序介孔二氧化硅纳米粒的多功能化,现已逐步应用于肿瘤的诊断和治疗等生物医学领域。本文就有序介孔二氧化硅纳米粒在制备、表面修饰及应用等几个方面的最新研究进展进行了综述。首先,重点介绍了不同pH条件下制备有序介孔二氧化硅纳米粒的方法和模板剂脱除方法,并简单归纳了各种方法的优缺点;其次,简要介绍了其表面稳定化和功能化修饰的研究现状,以及负载影像试剂和化疗药物的有序介孔二氧化硅纳米粒在肿瘤的多模成像诊断和靶向治疗中的应用进展;最后,总结了目前研究中还存在的问题并展望了其未来发展方向。

Abstract

Ordered mesoporous silica nanoparticles (MSNs) have drawn a great deal of attention in the biomedical fields because of their specific structures and unique physical chemistry properties. Combined with various functional materials or molecules, such as magnetic nanoparticles, fluorescent probes, antineoplastic drugs and targeting ligands, ordered mesoporous silica nanoparticles can be developed into the multifunctional nanomedicines in the application of diagnosis and therapy of tumor. The recent progress on synthetic methods, surface modification and application of MSNs are reviewed. First of all, the methods of synthesis in different pH medium and template removal are summarized in detail along with a brief introduction on their merits and drawbacks. Secondly, surface modification methods are described, including surface stabilization and surface functionalization. Thirdly, the application progress of targeted therapy and imaging diagnosis of MSNs loaded with imaging agents or chemotherapy drugs are also concluded. The final part outlines the challenges and perspectives.

Contents
1 Introduction
2 Preparation of MSNs
2.1 Methods of preparation in alkaline medium
2.2 Methods of preparation in acid medium
2.3 Methods of preparation in neutral medium
2.4 Methods of preparation in acid-base medium
3 Methods of removing templates
3.1 High-temperature calcination
3.2 Extraction method
3.3 Microwave digestion method
3.4 Oxidation method
3.5 Other methods
4 Surface modification and functionalization
4.1 Surface modification for stabilization
4.2 Surface modification for specific targeting
5 Application in the tumor diagnosis and therapy
5.1 Tumor diagnosis
5.2 Tumor therapy
5.3 Tumor theranostics
6 Conclusion and Outlook

Graphical abstract

关键词

有序介孔结构 / 二氧化硅纳米粒 / 制备与修饰 / 肿瘤 / 诊断与治疗

Key words

ordered mesoporous structure / silica nanoparticles / synthesis and modification / tumor / diagnosis and therapy

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曾峰, 潘真真, 张梦, 黄永焯, 崔彦娜, 徐勤. 有序介孔二氧化硅纳米粒的制备及其肿瘤诊疗应用[J]. 化学进展, 2015, 27(10): 1356-1373 DOI:10.7536/PC150437

Zeng Feng, Pan Zhenzhen, Zhang Meng, Huang Yongzhuo, Cui Yanna, Xu Qin. Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor[J]. Progress in Chemistry, 2015, 27(10): 1356-1373 DOI:10.7536/PC150437

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