微纳米粒子的形貌调控及其对药物/基因传递体系的影响

刘亚杰; 张鹏; 杜建委; 王幽香

doi:10.7536/PC150643

化学进展 ›› 2016, Vol. 28 ›› Issue (1) :67-74 DOI: 10.7536/PC150643

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微纳米粒子的形貌调控及其对药物/基因传递体系的影响

刘亚杰, 张鹏, 杜建委, 王幽香*

作者信息 +

Regulation the Morphology of Micro-and Nanoparticles and the Effect on Drug/Gene Delivery System

Liu Yajie, Zhang Peng, Du Jianwei, Wang Youxiang*

Author information +

文章历史 +

摘要

超分子组装体由于具有适合的微纳米尺寸、可控的结构和良好的生物相容性等特点,极大地促进了药物/基因传递体系的发展。拓扑结构(如形貌、尺寸)是影响药物/基因传递体系的重要因素,这方面研究正成为这一领域的研究热点。本文综述了调控组装体形貌的主要手段,包括聚合物链结构与组成、组装条件、外界刺激及聚合诱导的组装体形貌,初步探讨了微观形貌对药物/基因传递体系的影响,并对这一领域进行了展望。

Abstract

Supramolecular assembly has greatly promoted the development of drug/gene delivery system, due to the suitable micrometer or nanometer size, controllable structure and excellent biocompatibility. Recent studies have found that the topological structure plays a critical role in the drug/gene delivery process, which attracts great interest of researchers. In this paper, the main factors that regulate the morphology of micro-and nanoparticles are discussed, which mainly include composition of the copolymer, condition of self-assembly, external stimuli and polymerization-induced self-assembly. Then the effect of morphology on drug/gene delivery, challenges and prospects in this area are also discussed at the end of this review.

Contents
1 Introduction
2 Main methods of morphology regulation
2.1 Effect of the copolymer composition
2.2 Effect of self-assembly condition
2.3 Effect of external stimuli
2.4 Polymerization-induced self-assembly
3 The effect of morphology of drug/gene delivery system on blood circulation time and cell uptake
4 Conclusion

Graphical abstract

关键词

微纳米粒子 / 自组装 / 形貌调控 / 药物/基因载体

Key words

micro-and nanoparticles / self-assembly / morphology regulation / drug/gene vector

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刘亚杰, 张鹏, 杜建委, 王幽香. 微纳米粒子的形貌调控及其对药物/基因传递体系的影响[J]. 化学进展, 2016, 28(1): 67-74 DOI:10.7536/PC150643

Liu Yajie, Zhang Peng, Du Jianwei, Wang Youxiang. Regulation the Morphology of Micro-and Nanoparticles and the Effect on Drug/Gene Delivery System[J]. Progress in Chemistry, 2016, 28(1): 67-74 DOI:10.7536/PC150643

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