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蛋白表面分子印迹技术

张现峰, 杜学忠

化学进展 ›› 2016, Vol. 28 ›› Issue (1) :149-162

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化学进展 ›› 2016, Vol. 28 ›› Issue (1) :149-162 DOI: 10.7536/PC150719
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蛋白表面分子印迹技术

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Protein Surface Imprinting Technology

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文章历史 +

摘要

蛋白印迹材料在生物分离、生物传感和医用生物材料等领域具有很强的应用价值并受到广泛关注。尽管小分子印迹技术已经成功应用于很多领域,但蛋白分子印迹仍然是挑战性研究课题。本文总结了蛋白表面印迹技术领域的研究进展,根据不同的蛋白表面印迹材料,详细叙述了蛋白表面分子印迹薄膜、核壳微球、纳米线、凝胶微粒、单层膜等印迹材料的制备过程、印迹方法和选择识别性能,讨论了蛋白表面分子印迹方法的优缺点,阐明了蛋白分子印迹未来发展的方向。

Abstract

Protein-imprinted materials have drawn great attention for their applications in bioseparation, biosensing and biomedical materials. Despite the success of small molecular imprinting technology in many areas, protein imprinting remains a challenge. This review gives an overview of the progress in protein surface imprinting technology. The preparation process, imprinting methods, and selective recognition ability of the different imprinting materials, including protein surface imprinting membranes, core-shell structured microspheres, nanowires, microgels, and monolayers, are detailed. The advantages and disadvantages of the protein surface imprinting methods are discussed, and the trends and possible future development direction are also elaborated.

Contents
1 Introduction
2 Materials for protein surface imprinting
2.1 Protein surface imprinting membranes
2.2 Protein surface imprinting core-shell structured microspheres
2.3 Protein surface imprinting nanowires
2.4 Protein surface imprinting microgels
2.5 Protein surface imprinting monolayers
3 Conclusion and outlook

Graphical abstract

关键词

蛋白表面分子印迹技术 / 印迹材料 / 制备 / 印迹方法 / 蛋白识别

Key words

protein surface imprinting technology / imprinting materials / preparation / imprinting methods / protein recognition

引用本文

引用格式 ▾
张现峰, 杜学忠. 蛋白表面分子印迹技术[J]. 化学进展, 2016, 28(1): 149-162 DOI:10.7536/PC150719
Zhang Xianfeng, Du Xuezhong. Protein Surface Imprinting Technology[J]. Progress in Chemistry, 2016, 28(1): 149-162 DOI:10.7536/PC150719

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