水溶性共轭聚合物分子刷的研究进展

卢晓梅; 李杰; 胡文博; 邓卫星; 范曲立; 黄维

doi:10.7536/PC150913

化学进展 ›› 2016, Vol. 28 ›› Issue (4) :528-540 DOI: 10.7536/PC150913

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水溶性共轭聚合物分子刷的研究进展

^1*

^1,2*

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Recent Advances of the Water-Soluble Conjugated Polymer Brushes

Lu Xiaomei^1*, Li Jie¹, Hu Wenbo², Deng Weixing², Fan Quli², Huang Wei^1,2*

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摘要

水溶性共轭聚合物研究属于国际前沿研究领域,因其具有水溶性和超级信号放大作用,在生物传感领域展现出良好的应用前景.但由于传统水溶性线型共轭高分子两亲性结构特点,其含有的憎水性刚性共轭链在水溶液中易聚集,水分子对共轭链激发态的影响导致其发光效率低(一般小于30%),严重制约了其应用与拓展.如何方便有效构筑高分子的高支化是获得高荧光效率的关键.在本篇综述中,我们综述了水溶性共轭聚合物分子刷的合成技术,分析了其结构与光学性质的关系,为水溶性共轭聚合物分子刷的设计和制备提供指导.另外,总结了水溶性共轭聚合物分子刷在化学生物传感、生物成像、药物运输、癌症治疗等领域的应用,最后对水溶性共轭聚合物分子刷存在的主要问题以及未来的热点方向进行了分析和展望!

Abstract

Water-soluble conjugated polymers (WSCPs) have been widely used in chemical and biological sensing owning to their intriguing optoelectronic and biocompatible properties. However, these linear WSCPs suffer from the general drawbacks of low water-solubility and fluorescence quantum efficiency. Polymer brushes is a kind of unique macromolecules with a linear polymeric backbone and densely grafted side chains. Developing water-soluble conjugated polymer brushes (WSCPBs) is highly anticipated to solve the above mentioned problems. This article reviews the synthetic protocol and structure-properties relationship of WSCPBs to guide the design and preparation of new WSCPBs. In addition, we highlight the applications of WSCPBs in terms of sensor, bioimaging, drug delivery and surfactant. Finally, the future opportunities and challenges of WSCPBs are discussed.

Contents
1 Introduction
2 The synthesis of water-soluble conjugated polymer brushes
2.1 Grafting from approach
2.2 Grafting onto approach
2.3 Grafting through approach
3 Structure-properties relationship of water-soluble conjugated polymer brushes
3.1 Effects of conjugated backbone
3.2 Effects of graft side chains
4 Application of water-soluble conjugated polymer brushes
4.1 Sensor
4.2 Bioimaging
4.3 Drug delivery
4.4 Surfactant
5 Conclusion and outlook

Graphical abstract

关键词

水溶性 / 分子刷 / 共轭聚合物 / 生物成像

Key words

water-solubility / molecule brush / conjugated polymer / bioimaging

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卢晓梅, 李杰, 胡文博, 邓卫星, 范曲立, 黄维. 水溶性共轭聚合物分子刷的研究进展[J]. 化学进展, 2016, 28(4): 528-540 DOI:10.7536/PC150913

Lu Xiaomei, Li Jie, Hu Wenbo, Deng Weixing, Fan Quli, Huang Wei. Recent Advances of the Water-Soluble Conjugated Polymer Brushes[J]. Progress in Chemistry, 2016, 28(4): 528-540 DOI:10.7536/PC150913

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