连续流微反应

何涛; 马小波; 徐志宏; 王周玉

doi:10.7536/PC151130

化学进展 ›› 2016, Vol. 28 ›› Issue (6) :829-838 DOI: 10.7536/PC151130

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连续流微反应

何涛, 马小波, 徐志宏, 王周玉*

作者信息 +

The Continuous Flow Micro-Reaction

He Tao, Ma Xiaobo, Xu Zhihong, Wang Zhouyu*

Author information +

文章历史 +

摘要

近几个世纪,传统釜式反应为我们解决了大量化工产品需求的问题。但其本身存在着很多的缺点,如安全隐患、环境污染、能源消耗巨大、占地面积大以及工艺放大困难等。连续流微反应以其高效的传质传热、精确控温控时、安全稳定、无放大效应以及反应的实时监控等优点,能很好地解决传统釜式反应存在的问题。本文对连续流微反应在最近五年的研究进展进行了概述,特别对连续流中的硝化反应、叠氮基丙烯酸酯的热解反应、格氏反应与类格氏反应、偶联反应、胺化反应、氧化还原反应、缩合反应、环化反应、多步骤反应及常用连续流微反应器进行了介绍。同时,对连续流微反应的优缺点进行了简要评述。

Abstract

In recent centuries, the traditional tank reaction provides a large number of chemical products thermolysis of azidoacrylates. However, potential safety hazard, environmental pollution, huge energy consumption, huge site area and scale-up difficulties are the shortcomings. Continuous flow micro-reactor, with its high efficient heat transfer and mass transfer, accurate temperature control, security and stability, no amplification effect and the advantages of real-time monitoring, can solve the problems which existing in the traditional reaction. This review focuses on new findings in continuous flow micro-reaction in the last five years. The nitration reaction, thermolysis of azidoacrylates, Grignard and Grignard-type reactions, coupled reaction, amination reaction, oxidation and reduction reaction, condensation reaction, cyclization reaction, multistep reaction in flow condition and the continuous flow micro-reactors are introduced. Meanwhile, the potential strengths of the continuous flow micro-reaction as well as the weaknesses are discussed.

Contents
1 Introduction
2 Liquid phase reaction in flow condition
2.1 Nitration reaction
2.2 Thermolysis of azidoacrylates
2.3 Grignard and Grignard-type reaction
2.4 Coupled reaction
2.5 Amination reaction
2.6 Oxidation and Reduction reaction
2.7 Condensation reaction
2.8 Cyclization reaction
2.9 Other reactions
3 The gas-liquid reaction and gas-liquid-solid reaction in flow condition
4 Multistep reaction in flow condition
5 The continuous flow micro-reactors
6 Others
7 Conclusion

Graphical abstract

关键词

连续流 / 微反应 / 传统釜式反应 / 高效传质传热 / 放大效应

Key words

continuous flow / micro reaction / traditional tank reaction / high heat transfer and mass transfer / amplification effect

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何涛, 马小波, 徐志宏, 王周玉. 连续流微反应[J]. 化学进展, 2016, 28(6): 829-838 DOI:10.7536/PC151130

He Tao, Ma Xiaobo, Xu Zhihong, Wang Zhouyu. The Continuous Flow Micro-Reaction[J]. Progress in Chemistry, 2016, 28(6): 829-838 DOI:10.7536/PC151130

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