靶向性载体/基因复合物促进内皮细胞增殖

刘雯; 张立; 杨静; 郝雪芳; 李茜; 冯亚凯

doi:10.7536/PC151218

化学进展 ›› 2016, Vol. 28 ›› Issue (6) :954-960 DOI: 10.7536/PC151218

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靶向性载体/基因复合物促进内皮细胞增殖

^1,2*

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Targeting Carrier/Gene Complexes to Promote the Proliferation of Endothelial Cells

Liu Wen¹, Zhang Li², Yang Jing¹, Hao Xuefang¹, Li Qian¹, Feng Yakai^1,2*

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摘要

由于人工血管的表面缺乏活性内皮层,特别是小口径人工血管经常面临着长期通畅率低和再狭窄等难题,从而限制了其在临床上的应用。研究表明,通过基因复合物对内皮细胞转染可以在支架表面快速获得新生内皮层。近年来,基于靶向多肽修饰的基因载体为提高转染效率和降低载体毒性提供了有效的途径。本文详细介绍了目前用于基因转染的各种目的基因和基因载体,并以聚阳离子基因载体为基础,重点阐述了促进内皮细胞增殖的靶向性基因载体的研究进展,结合当前小口径人工血管研究进展,对采用基因转染方式实现其快速内皮化进行了分析和展望。

Abstract

Due to the lack of a living functional layer of endothelial cells (ECs) on the surface of artificial vascular scaffolds, especially small-diameter artificial vascular scaffolds, usually encounter long-term low patency and restenosis, limiting their clinical application. Nevertheless, it has been proved that re-endothelialization of artificial vascular scaffolds can be aquired rapidly via gene transfection towards endothelial cells, which is mediated by gene complexes. At present, gene carriers modified with targeting peptides provide a useful approach to promote transfection efficiency as well as decrease cytotoxicity. We introduce the desired genes and gene carriers applied in gene transfection detailedly. Based on polycationic gene carriers, the recent developments of gene carriers with targeting peptides for promoting the proliferation of ECs and endothelialization are highlighted in this review. Combined with the progress of small diameter artificial blood vessels, some perspectives on accomplishing rapid endothelialization via gene transfection are also presented.

Contents
1 Introduction
2 Non-viral gene carriers
3 Peptides for selective adhesion of endothelial cells
4 Gene carriers for targeting transfection of endothelial cells
5 Artificial vascular scaffolds modified by targeting carrier/gene complexes
6 Conclusion and outlook

关键词

人工血管支架 / 基因载体 / 靶向性 / 聚阳离子 / 内皮化

Key words

artificial vascular scaffolds / gene carrier / targeting / polycationic / endothelialization

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刘雯, 张立, 杨静, 郝雪芳, 李茜, 冯亚凯. 靶向性载体/基因复合物促进内皮细胞增殖[J]. 化学进展, 2016, 28(6): 954-960 DOI:10.7536/PC151218

Liu Wen, Zhang Li, Yang Jing, Hao Xuefang, Li Qian, Feng Yakai. Targeting Carrier/Gene Complexes to Promote the Proliferation of Endothelial Cells[J]. Progress in Chemistry, 2016, 28(6): 954-960 DOI:10.7536/PC151218

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Received	Published	Revised
2015-12-01	2016-06-15	2016-01-01
Online Date
2016-03-23

摘要

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