甘油在微生物代谢合成及生物催化中的应用

孙佳; 王普; 章鹏鹏; 黄金

doi:10.7536/PC160224

化学进展 ›› 2016, Vol. 28 ›› Issue (9) :1426-1434 DOI: 10.7536/PC160224

综述与评论

扫码查看或转发全文

甘油在微生物代谢合成及生物催化中的应用

孙佳, 王普*, 章鹏鹏, 黄金

作者信息 +

Application of Glycerol in Microbial Biosynthesis and Biocatalysis

Sun Jia, Wang Pu*, Zhang Pengpeng, Huang Jin

Author information +

文章历史 +

摘要

生物柴油是一种可再生能源，因其可替代石油来源的柴油而日益受到重视。随着生物柴油工业的蓬勃发展，其制备过程中的主要副产物甘油出现明显的产能过剩。作为一种廉价的清洁资源，甘油的深度开发和利用既是发展生物柴油工业的关键，也符合绿色化学的发展要求。近年来，甘油不仅作为重要的起始原料用于一些高附加值化学品的制备，而且因其独特的理化性质和易降解、生物相容性好等特性，在生物催化和绿色溶剂领域的应用研究日趋活跃。本文主要综述了甘油在工业微生物发酵、生物合成和绿色溶剂领域的研究进展，并就其应用中存在的一些问题，如甘油原料品质和微生物利用效率等进行分析，同时展望了甘油在生物催化领域的应用前景。

Abstract

Renewable biodiesel is a widely accepted energy for its alternative use of petroleum diesel. Glycerol is an inevitable byproduct of biodiesel production. With the vigorous development of biodiesel industry, there is an obvious oversupply of glycerol. This over-generated green resource urgently needs further exploration for the sustainable new applications, which is critical to the development of biodiesel industry and is in accordance with the demands of green chemistry. In recent years, glycerol has become one of the most important raw material for the production of high value-added chemicals. Moreover, based on its special physicochemical properties, as well as degradability and good biocompatibility, glycerol plays an increasingly important role in biocatalysis and can be used as a new green solvent. This paper mainly reviews the progress on glycerol for industrial biotechnology application in microbial fermentation, biosynthesis and green solvent. Some practical application problems involved in glycerol biotransformation, such as feedstock quality and microbial utilization efficiency, are also discussed in detail. The future application development of glycerol in biocatalysis is also prospected.

Contents
1 Introduction
2 Glycerol uptake and intracellular metabolism
3 Glycerol for microbial growth
4 Glycerol-based raw material for biotransformation
4.1 Glycerol to value-added chemicals
4.2 Solution to the inhibition of high glycerol concentration
4.3 Strategy for biotransformation efficiency
4.4 Bioconversion of crude glycerol
5 Application of glycerol in biocatalysis
5.1 Biocompatibility of glycerol
5.2 Application in asymmetric bioreduction
5.3 Glycerol as green solvent
5.4 Glycerol to deep eutectic solvents (DESs)
6 Conclusion

Graphical abstract

关键词

生物柴油 / 甘油 / 微生物代谢 / 生物催化 / 绿色溶剂

Key words

biodiesel / glycerol / microbial metabolism / biocatalysis / green solvent

引用本文

引用格式 ▾

孙佳, 王普, 章鹏鹏, 黄金. 甘油在微生物代谢合成及生物催化中的应用[J]. 化学进展, 2016, 28(9): 1426-1434 DOI:10.7536/PC160224

Sun Jia, Wang Pu, Zhang Pengpeng, Huang Jin. Application of Glycerol in Microbial Biosynthesis and Biocatalysis[J]. Progress in Chemistry, 2016, 28(9): 1426-1434 DOI:10.7536/PC160224

登录浏览全文

4963

注册一个新账户忘记密码

参考文献

原文顺序 | 出版日期 | 本文引用

[1] Okoye P U, Hameed B H. Renew. Sust. Energ. Rev., 2016, 53:558.
[2] Ye X P, Ren S J. Soy-Based Chemicals and Materials. Knoxville:ACS Symposium Series, 2014.
[3] Yang F X, Hanna M A, Sun R C. Biotechnol. Biofuels, 2012, 5:13.
[4] García J I, García-Marín H, Pires E. Green Chem., 2014, 16:1007.
[5] Zhou C H, Beltramini J B, Fan Y X, Lu G Q. Chem. Soc. Rev., 2008, 37:527.
[6] Wolfson A, Snezhko A, Meyouhas T, Tavor D. Green Chem. Lett. Rev., 2012, 5(1):7.
[7] Díaz-Álvarez A E, Francos J, Lastra-Barreira B, Crochet P, Cadierno C. Chem. Commun., 2011, 47:6208.
[8] Wolfson A, Dlugy C, Shotland Y, Tavor D. Tetrahedron Lett., 2009, 50:5951.
[9] Azua A, Mata J A, Eduardo P E. Organometallics, 2011, 30(20):5532.
[10] Azua A, Mata J A, Peris E, Lamaty F, Martinez J, Colacino E. Organometallics, 2012, 31(10):3911.
[11] Gu Y L, Jérôme F. Green Chem., 2010, 12:1127.
[12] Feng S, Yan Y B. Proteins, 2008, 71:844.
[13] Bhaganna P, Bielecka A, Molinari G, Hallsworth J. E. Curr. Genet., 2015, DOI:10.1007/s00294-015-0539-1.
[14] Fields P A, Wahlstrand B D, Somero G N. Eur. J. Biochem., 2001, 268:4497.
[15] Wang Z X, Zhuge J, Fang H Y, Prior B A. Biotechnol. Adv., 2001, 19:201.
[16] Silva G P D, Mack M, Contiero J. Biotechnol. Adv., 2009, 27:30.
[17] Rodriguez A, Wojtusik M, Ripoll V, Santos V E, Garcia-Ochoa F. Bioresource Technol., 2016, 200:830.
[18] Jiang W, Wang S Z, Wang Y P, Fang B S. Biotechnol. Biofuels, 2016, 9:57.
[19] Easterling E R, French W T, Hernandez R, Licha M. Bioresource Technol., 2009, 100:356.
[20] Alvarez M de F, Medina R, Pasteris S E, Strasser de Saad A M, Sesma F. J. Mol. Microbiol. Biotechnol., 2004, 7:170.
[21] Zhou X, Zhou X L, Xu Y, Yu S Y. Bioproc. Biosyst. Eng., 2016, 39(8):1315.
[22] Ringel A K, Wilkens E, Hortig D, Willke T, Vorlop K D. Appl. Microbiol. Biotechnol., 2012, 93:1049.
[23] Dobson R, Gray V, Rumbold K. J. Ind. Microbiol. Biotechnol., 2012, 39:217.
[24] Clomburg J M, Gonzalez R. Trends Biotechnol., 2013, 31(1):20.
[25] Dro?d?yńska A, Pawlicka J, Kubiak P, Ko Ds' mider A, Pranke D, Olejnik-Schmidt A, Czaczyk K. New Biotechnol., 2014, 31(5):402.
[26] Wilkens E, Ringel A K, Hortig D, Willke T, Vorlop K D. Appl. Microbiol. Biotechnol., 2012, 93:1057.
[27] Dharmadi Y, Murarka A, Gonzalez R. Biotechnol. Bioeng., 2006, 94:821
[28] Rodriguez A, Wojtusik M, Ripoll V, Santos V E, Garcia-Ochoa F. Bioresource Technol., 2016, 200:830.
[29] Xu Y Z, Guo N N, Zheng Z M, Ou X J, Liu H J, Liu D H. Biotechnol. Bioeng., 2009, 104(5):965.
[30] Tang X M, Tan Y S, Zhu H, Zhao K, Shen W. Appl. Environ. Microb., 2009, 75(6):1628.
[31] Silva G P D, Cristian J, Lima C J B D, Contiero J. Catal. Today, 2015, 257:259.
[32] Kaeding T, DaLuz J, Kube J, Zeng A P. Bioproc. Biosyst. Eng., 2015, 38(3):575.
[33] Zheng X J, Jin K Q, Zhang L, Wang G, Liu Y P. Braz. J. Microbiol., 2016, 47:129.
[34] Li M H, Wu J, Liu X, Lin J P, Wei D Z, Chen H. Bioresource Technol., 2010, 101:8294.
[35] Cho S, Kim T, Woo H M, Kim Y, Lee J, Um Y. Biotechnol. Biofuels., 2015,8:146.
[36] Yang T W, Rao Z M, Zhang X, Xu M J, Xu Z H, Yang S T. Microb. Cell Fact., 2015, 14:122.
[37] Ahn J H, Sang B I, Um Y. Bioresource Technol., 2011, 102:4934.
[38] Malaviya A, Jang Y S, Lee S Y. Appl. Microbiol. Biot., 2012, 93(4):1485.
[39] Wang Q, Yang P, Liu C S, Xue Y C, Xian M, Zhao G. Bioresource Technol., 2013, 131:548.
[40] Kamzolova S V, Fatykhova A R, Dedyukhina E G, Anastassiadis S G, Golovchenko N P, Morgunov I G. Food Technol. Biotechnol., 2011, 49(1):65.
[41] Scholten E, Renz T, Thomas J. Biotechnol. Lett., 2009, 31:1947.
[42] Vlysidis A, Binns M, Webb C, Theodoropoulos C. Biochem. Eng. J., 2011, 58/59:1.
[43] Zhu Y F, Li J H, Tan M, Liu L, Jiang L L, Sun J, Lee P, Du G C, Chen J. Bioresource Technol., 2010, 101:8902.
[44] Murakami N, Oba M, Iwamoto M, Tashiro Y, Noguchi T, Bonkohara K, Abdel-Rahman M A, Zendo T, Shimoda M, Sakai K, Sonomoto K. J. Biosci. Bioeng., 2016, 121(1):89.
[45] Habe H, Shimada Y, Yakushi T, Hattori H, Ano Y, Fukuoka T, Kitamoto D, Itagaki M, Watanabe K, Yanagishita H, Matsushita K, Sakaki K. Appl. Environ. Microb., 2009, 75:7760.
[46] Dounavisa A S, Ntaikoua I, Lyberatos G. Bioresource Technol., 2015, 198:701.
[47] Nwachukwu R E S, Shahbazi A, Wang L, Ibrahim S, Worku M, Schimmel K. AMB Express, 2012, 2:20.
[48] Gao C, Li Z, Zhang L J, Wang C, Li K, Ma C Q, Xu P. Green Chem., 2015, 17:804
[49] Raška J, Skopal F, Komers K, Machek J. Collect. Czech. Chem. Commun., 2007, 72:1269.
[50] Cheng K K, Zhang J A, Liu D H, Sun Y, Liu H J, Yang M D, Xu J M. Process Biochem., 2007, 42:740.
[51] Jensen T Ø, Kvist T, Mikkelsen M J, Westermann P. AMB Express, 2012, 2:44.
[52] Zhou P P, Zhang Y, Wang P X, Xie J L, Ye Q. Ann. Microbiol., 2014, 64:219.
[53] Samul D, Leja K, Grajek W. Ann. Microbiol., 2014, 64:891.
[54] Ardi M S, Aroua M K, Hashim N A. Renew. Sust. Energ. Rev., 2015, 42:1164.
[55] Jun S A, Moon C, Kang C H, Kong S W, Sang B I, Um Y. Appl. Biochem. Biotechnol., 2010, 161:491.
[56] Hubálek Z. Cryobiology, 2003, 46:205.
[57] Gekkot K, Timasheff S N. Biochemistry, 1981, 20:4667.
[58] Chen S, Land H, Berglund P, Humble M S. J. Mol. Catal. B:Enzym., 2016, 124:20.
[59] Torrelo G, Hanefeld U, Hollmann F. Catal. Lett., 2015, 145:309.
[60] Ni Y, Xu J H. Biotechnol. Adv., 2012, 30:1279.
[61] Hilker I, Gutiérrez M C, Furstoss R, Ward J, Wohlgemuth R, Alphand V. Nat. Protoc., 2008, 3:546.
[62] Hao G, Chen H Q, Gu Z N, Zhang H, Chen W, Chen Y Q. Microb. Cell Fact., 2015, 14:205.
[63] Beltrán-Prieto J C, Kolomazník K, Pecha J. Aust. J. Chem., 2013, 66:511.
[64] Zhang Y, Gao F, Zhang S P, Su Z G, Ma G H, Wang P. Bioresource Technol., 2011, 102:1837.
[65] Rocha-Martin J, Acosta A, Guisan J M, López-Gallego F. ChemCatChem, 2015, 7:1939.
[66] Taketomi S, Asano M, Higashi T, Shoji M, Sugai T. J. Mol. Catal. B:Enzym., 2012, 84:83.
[67] Wang S S, Xu Y, Zhang R Z, Zhang B T, Xiao R. Process Biochem., 2012, 47:1060.
[68] Li J, Wang P, He J Y, Huang J, Tang J. Appl. Microbiol. Biotechnol., 2013, 97:6685.
[69] 王普(Wang P), 黄金(Huang J), 丁徐中(Ding X Z). CN104893989A, 2015.
[70] Nemati F, Hosseini M M, Kiani H. J. Saudi. Chem. Soc., 2013, DOI:10.1016/j.jscs.2013. 02.004.
[71] Hernáiz M J, Alcántara A R, García J I, Sinisterra J V. Chem.-Eur. J., 2010, 16:9422.
[72] Wolfson A, Dlugy C, Tavor D, Blumenfeld J, Shotland Y. Tetrahedron-Asymmetry, 2006, 17:2043.
[73] Andrade L H, Piovan L, Pasquini M D. Tetrahedron-Asymmetry, 2009, 20:1521.
[74] Cheng C, Nian Y C. J. Mol. Catal. B:Enzym., 2016, 123:141.
[75] Li J, Wang P, Huang J, Sun J. Bioresource Technol., 2015, 175:42.
[76] Wang N Q, Li J, Sun J, Huang J, Wang P. Biochem. Eng. J., 2015, 101:119.
[77] Smith E L, Abbott A P, Ryder K S. Chem. Rev., 2014, 114:11060.
[78] Müller C R, Lavandera I, Gotor-Fernández V, María P D D. ChemCatChem, 2015, 7:2654.
[79] Bewley B R, Berkaliev A, Henriksen H, Ball D B, Ott L S. Fuel Process Technol., 2015, 138:419.
[80] Maugeri Z, María P D D. ChemCatChem, 2014, 6:1535.
[81] Zhao H, Baker G A, Holmes S. J. Mol. Catal. B:Enzym., 2011, 72:163.
[82] Xu P, Cheng J, Lou W Y, Zong M H. RSC Adv., 2015, 5:6357.
[83] Tian X M, Zhang S Q, Zheng L Y. J. Microbiol. Biotechnol., 2016, 26:80.