基于分子印迹技术的电化学发光分析

杨钰昆; 王小敏; 方国臻; 云雅光; 郭婷; 王硕

doi:10.7536/PC160326

化学进展 ›› 2016, Vol. 28 ›› Issue (9) :1351-1362 DOI: 10.7536/PC160326

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基于分子印迹技术的电化学发光分析

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^1,2*

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Electrochemiluminescence Analysis Based on Molecular Imprinting Technique

Yang Yukun^1,2, Wang Xiaomin^1,2, Fang Guozhen^1,2, Yun Yaguang^1,2, Guo Ting^1,2, Wang Shuo^1,2*

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摘要

基于分子印迹技术的电化学发光分析是近几年刚刚发展起来的新型分析方法，兼具分子印迹技术与电化学发光方法两者的优点，具有高灵敏度、高选择性、可控性好、易于微型化和操作简单等特点，在生命科学、食品安全及环境监测等领域有着广泛的应用前景。本综述简要介绍了常用的电化学发光体系和基本原理，综述了近年来分子印迹电化学发光分析的主要研究进展，对不同类型分子印迹电化学分析的构建方法、原理及所构建方法的性能（包括灵敏度、选择性、检测范围和稳定性等）进行了评述。基于分子印迹技术的电化学发光分析主要可以分为三类：制备固态发光电极、非固态发光电极构建分子印迹电化学发光传感器和分子印迹固相萃取与电化学发光分析联用，其中制备固态发光电极用于构建分子印迹电化学发光传感器最有发展前景。最后，本综述也对分子印迹电化学发光分析今后的发展趋势和方向进行了展望。

Abstract

Electrochemiluminescence (ECL) analysis based on molecular imprinting technique, as a new analysis method, has made great progress in recent years. Molecular imprinted ECL analysis owns the advantages of both ECL analysis and molecular imprinting technology, namely high sensitivity, high selectivity, good controllability, easy miniaturization and simple operation, suggesting a wide range of applications in the fields of life sciences, food safety and environmental monitoring. In this review, the common ECL systems and basic ECL principles are introduced in detail, and the research advances of molecular imprinted ECL analysis are reviewed. The ECL mechanism mainly includes annihilation type ECL mechanism and co-reactant type ECL mechanism, examples based on ECL mechanism are introduced. Construction procedure, principles and performance of different types of molecular imprinted ECL analysis, including sensitivity, selectivity, detection range and stability of the established methods, are remarked extensively. The development of molecular imprinted polymers (MIPs)-based ECL analysis could be divided into three types:MIPs-ECL sensor based on solid-state light-emitting electrode, MIPs-ECL sensor based on non-solid-state light-emitting electrode and MIPs based-solid phase extraction coupled with ECL analysis. Among the three types mentioned above, the fabrication of solid-state light-emitting electrode to establish molecular imprinted ECL sensor is the most promising direction, in which the organic combination of ECL light-emitting materials and molecular imprinted material is achieved. In addition, the outlook of future development directions and trends of molecular imprinted ECL analysis are discussed.

Contents
1 Introduction
2 Common ECL system and ECL mechanism
2.1 Annihilation type ECL mechanism
2.2 Co-reactant type ECL mechanism
3 Research advances of MIPs-based ECL analysis
3.1 MIPs-ECL sensor based on solid-state light-emitting electrode
3.2 MIPs-ECL sensor based on non-solid-state Light-emitting electrode
3.3 MIPs based-solid phase extraction coupled with ECL
4 Conclusion

Graphical abstract

关键词

分子印迹 / 电化学发光 / 固态发光电极 / 固相萃取

Key words

molecular imprinting / electrochemiluminescence / solid-state light-emitting electrode / solid phase extraction

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杨钰昆, 王小敏, 方国臻, 云雅光, 郭婷, 王硕. 基于分子印迹技术的电化学发光分析[J]. 化学进展, 2016, 28(9): 1351-1362 DOI:10.7536/PC160326

Yang Yukun, Wang Xiaomin, Fang Guozhen, Yun Yaguang, Guo Ting, Wang Shuo. Electrochemiluminescence Analysis Based on Molecular Imprinting Technique[J]. Progress in Chemistry, 2016, 28(9): 1351-1362 DOI:10.7536/PC160326

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