聚酰胺类多肽二级结构模拟物的结构设计与性质分析

王志鹏; 田长麟; 郑基深

doi:10.7536/PC160343

化学进展 ›› 2016, Vol. 28 ›› Issue (9) :1328-1340 DOI: 10.7536/PC160343

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聚酰胺类多肽二级结构模拟物的结构设计与性质分析

^1,2

^1*

作者信息 +

The Structural Designs and Property Analysis of Polyamide Based Structures as Peptide Secondary Structure Mimics

Wang Zhipeng^1,2, Tian Changlin¹, Zheng Jishen^1*

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摘要

多肽与蛋白质具有结构支持、酶促催化、蛋白-蛋白相互作用等一系列功能。其中，二级结构作为少数氨基酸参与的相对局域性的结构，是一切高级结构的基础。为了模拟天然多肽的结构与功能，人们成功设计并合成了多种非天然的寡聚物结构。这些拟肽或类肽结构能有效地模拟以α-螺旋、转角为主体的多肽二级结构。二级结构模拟物具有重要的理论意义，并被进一步用于蛋白-蛋白相互作用的抑制剂研究与新药设计中。本文从分析多肽的二级结构特征入手，分类阐述了目前的各类多肽二级结构模拟物，并重点分析了最为主要的基于酰胺键型的模拟物的设计与结构多样性。同时，本文提出一系列形象化的命名手段进行分类，如χ肽、ζ/ξ-肽及ζ-ξ-肽等。

Abstract

The peptides and proteins lay the foundation of diverse functions including structural supporting, enzymatic catalysis, protein-protein interactions etc. Specifically, secondary structures are essential elements for any possible higher structures, as rather localized motifs with limited amino acid residues involved. Nowadays, different non-natural oligomers have been developed for the peptide structural and functional mimicking, such as α-helix and turns. Protein secondary structure mimics are a group of organic compounds with theoretical importance, which can be further applied to protein-protein inhibitor study as well as drug design. This manuscript starts with the property analysis of typical protein secondary structures, followed by the introduction of current peptide secondary structure mimics. These foldamers are divided into three main groups, and the design principles as well as the structural diversity of oligo/poly-amide based peptide secondary structure mimics are emphasized. Additionally, the draft provides several visualizable nomenclature, including χ-peptides, ζ/ξ-peptides, and ζ-ξ-peptides.

Contents
1 Introduction
2 Analysis on the peptide secondary structures
2.1 α-helix
2.2 β-strain/sheet
2.3 Turns
3 Oligo/poly-amide based peptide secondary structure mimics
3.1 β-peptide & its analogs
3.2 γ-peptide & its analogs
3.3 χ-peptides
3.4 ζ/ξ-peptides
3.5 ζ-ξ-peptides
3.6 Peptoids
3.7 Other unnatural oligo/poly-amides
4 Helix mimics based on the stick structures
5 Turn mimics based on the introduction of non-natural structures
6 Conclusion

Graphical abstract

关键词

多肽 / 二级结构 / 拟肽 / 二级结构模拟物 / 聚酰胺

Key words

peptide / secondary structure / peptoid / secondary structure mimic / polyamide

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王志鹏, 田长麟, 郑基深. 聚酰胺类多肽二级结构模拟物的结构设计与性质分析[J]. 化学进展, 2016, 28(9): 1328-1340 DOI:10.7536/PC160343

Wang Zhipeng, Tian Changlin, Zheng Jishen. The Structural Designs and Property Analysis of Polyamide Based Structures as Peptide Secondary Structure Mimics[J]. Progress in Chemistry, 2016, 28(9): 1328-1340 DOI:10.7536/PC160343

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