仿衣壳结构的巨大中空超分子纳米容器的多组分自组装构筑及其功能

张广录; 张婷; 周黎鹏; 孙庆福

doi:10.7536/PC160418

化学进展 ›› 2016, Vol. 28 ›› Issue (9) :1289-1298 DOI: 10.7536/PC160418

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仿衣壳结构的巨大中空超分子纳米容器的多组分自组装构筑及其功能

^1,2

^1*

作者信息 +

Capsid-Inspired Multi-Component Self-Assembly of Nanocontainers: Structure, Functionalization, and Applications

Zhang Guanglu^1,2, Zhang Ting¹, Zhou Lipeng¹, Sun Qingfu^1*

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摘要

在自然界病毒衣壳及笼状蛋白质大分子结构的启发下，运用V型双齿桥连吡啶配体和具有平面四方构型的Pd²⁺离子的溶液配位自组装，一系列具有M_nL_2n经验分子式的多组分巨大中空“纳米容器”型超分子结构被成功构筑。通过在配体内外引入官能团的策略，可以简单地实现衣壳骨架结构的内外功能化。内功能化后的“纳米容器”具有特殊的高密度相，不仅可以实现对不同类型客体分子的包裹，而且可以作为“纳米反应器”实现尺寸均一可控纳米粒子的原位合成以及小分子的催化转化。外功能化的核壳结构则可以对寡肽、DNA等生物分子具有特定的识别作用。本文对此类“纳米容器”型超分子的设计原理、自组装合成与表征、以及功能化应用等方面进行了综述。

Abstract

Inspired by the spontaneous self-assembly of hollow virus capsids and protein cages found in nature, a family of hollow spherical structure with general formula M_nL_2n can be obtained via the coordination-directed multi-component self-assembly of bent bis(pyridine) ligands and square-planar Pd²⁺ ions. Endo and exo-hedral functionalization of the nanocontainer complexes have been realized by introduction of functional groups into the organic ligands. Due to the nanoconcentrator effect, endo-functionalised spherical complex could be used not only for the template-synthesis of mono-dispersed polymers or nanoparticles, but also for the catalytic transformations of small substrates. Meanwhile, exo-functionalized complexes can selectively recognize a variety of substrates, such as oligonucleotides and DNA. The design principles, synthesis, characterization and functional applications of such nano-container molecules are summarized in this paper.

Contents
1 Introduction
2 Design and synthesis of the nano-containers
3 Functionalization and applications
3.1 Functional cavity
3.2 Functional surface
4 Conclusion and outlook

Graphical abstract

关键词

自组装 / 纳米容器 / 功能化 / 应用

Key words

self-assembly / nano-containers / functionalization / application

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张广录, 张婷, 周黎鹏, 孙庆福. 仿衣壳结构的巨大中空超分子纳米容器的多组分自组装构筑及其功能[J]. 化学进展, 2016, 28(9): 1289-1298 DOI:10.7536/PC160418

Zhang Guanglu, Zhang Ting, Zhou Lipeng, Sun Qingfu. Capsid-Inspired Multi-Component Self-Assembly of Nanocontainers: Structure, Functionalization, and Applications[J]. Progress in Chemistry, 2016, 28(9): 1289-1298 DOI:10.7536/PC160418

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