增强纳米药物载体肿瘤内渗透分布的研究进展

韩冬琳, 亓洪昭, 赵瑾, 龙丽霞, 任玉, 原续波

doi:10.7536/PC160423

化学进展 ›› 2016, Vol. 28 ›› Issue (9) :1397-1405 DOI: 10.7536/PC160423

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增强纳米药物载体肿瘤内渗透分布的研究进展

韩冬琳, 亓洪昭, 赵瑾, 龙丽霞, 任玉, 原续波

作者信息 +

Enhancement of Intra-Tumor Penetration and Distribution of Nano-Drug Carriers

Han Donglin, Qi Hongzhao, Zhao Jin, Long Lixia, Ren Yu, Yuan Xubo

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文章历史 +

摘要

利用纳米载体负载小分子化疗药物、蛋白和基因有助于降低这些药物的毒副作用，在肿瘤治疗中发挥着重要作用。然而，由于肿瘤独特的病理生理学特点，纳米药物载体在肿瘤中的分布并不均匀，无法有效渗透到肿瘤深部，使药物的疗效受到限制。通过控制纳米药物载体的粒径、表面电位、表面功能基团和形状等理化性质，可以实现其在肿瘤组织中的有效扩散。本文从无机和有机纳米药物载体两个体系出发，综述了通过对纳米药物载体的组成、结构设计和理化性质的调控，促进其在肿瘤组织中均匀分布及深度渗透的研究进展，并展望了面临的挑战和可能的解决途径。

Abstract

The tumor therapeutics effect of chemotherapeutant, proteins and genes could be improved when they are loaded in nano-drug carriers. But in some cases the therapeutics effects are modest due to the poor penetration and distribution of nano-carriers in the heterogeneous tumor tissue. During the recent years, increasing efforts have been dedicated to improve the intra-tumor penetration by controlling the size, surface zeta potential, targeting agents, and shape of nano-drug carriers. This paper reviews the progress in enhancement of intra-tumor penetration and distribution of nano-drug carriers through the modification of their components, structures and physicochemical properties. The challenges of nano-drug carriers in tumor treatment are raised and the possible solutions are proposed.

Contents
1 Introduction
2 Inorganic nano-drug carriers
2.1 Meso-porous silicon nano-drug carriers
2.2 Gold nano-drug carriers
3 Organic nano-drug carriers
3.1 Micelles
3.2 Dendrimers
3.3 Liposomes
3.4 Polymer nanocapsule
4 Conclusion

Graphical abstract

关键词

纳米药物载体 / 理化性质 / 肿瘤 / 渗透 / 微观分布

Key words

nano-drug carriers / physicochemical properties / tumor / penetration / microscopic distribution

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韩冬琳, 亓洪昭, 赵瑾, 龙丽霞, 任玉, 原续波. 增强纳米药物载体肿瘤内渗透分布的研究进展[J]. 化学进展, 2016, 28(9): 1397-1405 DOI:10.7536/PC160423

Han Donglin, Qi Hongzhao, Zhao Jin, Long Lixia, Ren Yu, Yuan Xubo. Enhancement of Intra-Tumor Penetration and Distribution of Nano-Drug Carriers[J]. Progress in Chemistry, 2016, 28(9): 1397-1405 DOI:10.7536/PC160423

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