有机光热转换材料及其在光热疗法中的应用

陈瑞*, 王晶晶, 乔宏志

doi:10.7536/PC160638

化学进展 ›› 2017, Vol. 29 ›› Issue (2/3) :329-336 DOI: 10.7536/PC160638

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有机光热转换材料及其在光热疗法中的应用

陈瑞*, 王晶晶, 乔宏志

作者信息 +

Organic Photothermal Conversion Materials and Their Application in Photothermal Therapy

Rui Chen*, Jingjing Wang, Hongzhi Qiao

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文章历史 +

摘要

光热疗法（photothermal therapy，PTT）作为一种新型的肿瘤治疗技术，由于其对肿瘤高效的消除能力和对正常组织极低的伤害，近年来受到了强烈的关注。在过去的十余年中，许多无机光热转换材料，尤其是金和碳的纳米材料，已经被报道广泛用于光热治疗的研究中。随着纳米技术和纳米材料的发展，光热试剂的种类和性能也得到不断提升。在光热治疗优异疗效的激励下，人们越来越关心其走向临床应用的可能。近年来出现的一些新型有机光热转换试剂，因为其能够克服无机材料不可生物降解的特点而得到快速地发展。本文主要综述了最近几年发展起来的几种典型的有机光热转换纳米材料，包括小分子染料类、超分子复合物类以及共轭聚合物类，介绍了它们应用在肿瘤光热治疗的研究，并简单描述了成像指导下的光热治疗以及联合治疗方面的应用。最后，总结了现有的有机光热试剂的种类，指出其研究发展方向，分析了光热疗法目前面临的难题与挑战，及其走向临床应用的前景。

Abstract

Photothermal therapy (PTT), as a new type of tumor treatment technology, has received intensive attention recently due to its high efficiency for tumor inhibition and low damage to normal tissue. Over the past decade, many photothermal conversion agents have been widely used in the research of PTT, especially inorganic nanomaterials with surface plasmon resonance properties, such as gold based nanoparticles. With the development of nanotechnology and nanomaterials, the types and properties of photothermal agents have been increasingly improved. Spired by the excellent cancer therapy effect of photothermal therapy, people pay more attention to the possibility of its clinical application. In recent years, organic photothermal agents have been developed rapidly, due to their abilities to overcome the non-biodegradable characteristics of inorganic materials. This article summarizes the recently developed research of several typical photothermal nanomaterials, including small molecular dyes, supramolecular complexes and conjugated polymers. Based on these organic agents, various biocompatible materials are developed for clinical photothermal therapy. And the application of the imaging guided photothermal therapy and combined therapy is briefly described. In the end, the primary categories and development direction of organic photothermal agents are summarized. And the problems and challenges of clinical photothermal therapy are pointed out.

Contents
1 Introduction
2 Small molecular dyes
2.1 Indocyanine green
2.2 Prussian blue
2.3 Thiadiazole derivatives
3 Supramolecular complexes
3.1 Porphysomes
3.2 BPDI/(CB[7])₂
4 Conjugated polymers
4.1 Polyaniline
4.2 Polypyrrole
4.3 PEDOT:PSS
4.4 Polydopamine
5 Other applications of photothermal therapy
5.1 Imaging-guided photothermal therapy
5.2 Combined cancer therapy
6 Conclusion and outlook

Graphical abstract

关键词

有机纳米材料 / 光热转换试剂 / 光热疗法

Key words

organic nanomaterials / photothermal conversion agents / photothermal therapy

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陈瑞*, 王晶晶, 乔宏志. 有机光热转换材料及其在光热疗法中的应用[J]. 化学进展, 2017, 29(2/3): 329-336 DOI:10.7536/PC160638

Rui Chen*, Jingjing Wang, Hongzhi Qiao. Organic Photothermal Conversion Materials and Their Application in Photothermal Therapy[J]. Progress in Chemistry, 2017, 29(2/3): 329-336 DOI:10.7536/PC160638

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