生物分子响应性高分子材料

王宏喜; 熊雨婷; 卿光焱*; 孙涛垒*

doi:10.7536/PC161217

化学进展 ›› 2017, Vol. 29 ›› Issue (4) :348-358 DOI: 10.7536/PC161217

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生物分子响应性高分子材料

王宏喜, 熊雨婷, 卿光焱*, 孙涛垒*

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Biomolecular Responsive Polymer Materials

Hongxi Wang, Yuting Xiong, Guangyan Qing*, Taolei Sun*

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摘要

在智能高分子材料中，生物分子响应性高分子能够在糖类、多肽和酶等生物分子的刺激下发生宏观性质（如：体积、表面浸润性和硬度等）的大幅转变。生物分子响应性聚合物材料包括水凝胶、共聚物膜等类型，一般通过与生物分子间的氢键、分子间作用力等弱相互作用实现响应过程，在组织工程、功能材料、生物传感、药物可控释放等领域有广泛应用前景，吸引了大量科研人员的关注。与传统外源性刺激（温度、pH、光等）相比，生物分子作为刺激源的智能高分子材料具有更好的靶向性和生物相容性，能满足生物医用材料在人体内的应用，可以作为开发新一代精准药物的靶向释放平台。本文分别对糖类、蛋白、酶和DNA四类生物分子响应性高分子材料的结构设计、响应机制及相关应用进行概述，并对生物分子响应性高分子的发展方向作了展望。

Abstract

Among smart polymer materials,biomolecule-responsive polymer is capable of responding to the binding/releasing of biological molecules, for example saccharides, peptides, enzymes, which resulting in dramatic transition in macroscopic properties of materials, such as volume, surface wettability and stiffness. These materials include hydrogels, copolymer films and some other types. The response process between material and biomolecules is generally realized by hydrogen bonds, intermolecular forces and other weak interactions. Due to their excellent designability and good biocompatibility, biomolecule-responsive polymers have many application prospects in biomedical fields such as biosensing, tissue engineering, microfluidic devices, bioseparation and so on, which have attracted more and more interests. Compared with many traditional exogenous stimuli, such as temperature, pH, magnetic field, electric field, or light irradiation, biomolecule-responsive polymers have better targeting ability. Therefore, they can better satisfy the high demand of biomaterials applied in vivo. Furthermore, biomolecule-responsive materials can be developed to the new generation of material for disease diagnosis and drug controllable release. Herein, according to the categories of biomolecules, like saccharides, proteins, enzymes and DNA, the design and response mechanism of biomolecule-responsive polymers materials has been summarized and the applications of these materials are also introduced. Finally, the research prospect of these fields are proposed.

Contents
1 Introduction
2 Saccharides-responsive
3 Protein-responsive
4 Enzyme-responsive
5 DNA-responsive
6 Conclusion

Graphical abstract

关键词

智能材料 / 响应性高分子 / 生物界面 / 生物传感 / 构象转变

Key words

smart material / responsive polymer / biointerface / biosensing / conformational transition

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王宏喜, 熊雨婷, 卿光焱*, 孙涛垒*. 生物分子响应性高分子材料[J]. 化学进展, 2017, 29(4): 348-358 DOI:10.7536/PC161217

Hongxi Wang, Yuting Xiong, Guangyan Qing*, Taolei Sun*. Biomolecular Responsive Polymer Materials[J]. Progress in Chemistry, 2017, 29(4): 348-358 DOI:10.7536/PC161217

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