基于长余辉纳米发光探针的生物传感检测和成像

刘瑶瑶; 刘敬民; 方国臻; 张咚咚; 王青华; 王硕

doi:10.7536/PC170301

化学进展 ›› 2017, Vol. 29 ›› Issue (6) :667-682 DOI: 10.7536/PC170301

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基于长余辉纳米发光探针的生物传感检测和成像

^1,2,3

^1,2,3*

作者信息 +

Biosensor Detection and Imaging Based on Persistence Luminescence Nanoprobe

Yaoyao Li¹, Jingmin Liu^1,2,3, Guozhen Fang¹, Dongdong Zhang¹, Qinghua Wang¹, Shuo Wang^1,2,3*

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摘要

长余辉纳米粒子由于其特殊的发光现象、超长的余辉寿命、可实现免原位激发以及光谱发射区域可被调控至“生物光学透明窗口”内等特征而被广泛应用于光学传感检测和生物医学成像领域。近年来，长余辉纳米发光探针的合成和应用吸引了光谱学、声子学、光化学、材料科学领域的极大关注。本文对长余辉纳米分子探针的合成方法、颗粒表面功能化及其作为靶向探针在体内和体外进行传感检测及活体成像的应用进行深入探讨。本文主要讨论Mn²⁺和Cr³⁺掺杂的红色-近红外发光纳米材料，特别是镓锗酸盐，其具有强烈的近红外持续发光，超过两周的余辉寿命更适合于生物成像的应用。功能化的红色近红外长余辉纳米材料为长期实时监测体内生理学过程和疾病的诊断提供有前景的技术平台。最后本文对长余辉材料应用面临的挑战和未来的发展趋势进行了展望。

Abstract

Owing to the unique luminescence phenomenon and the super long afterglow life, the persistent luminescence nanomaterials (PLNPs) can achieve in vitro excitation and the spectral emission regions can be regulated into the “biological transparent window”, which were widely used in optics sensor detection and bioimaging field of disease targeted diagnosis and treatment. In recent years, the syntheses and applications of PLNPs nanoprobe have attracted great attention in the areas of spectroscopy, photonics, photochemistry and materials science. This paper reviews the synthesis methods and surface modification of PLNPs molecular nanoprobe as well as their application in detection and bioimaging in vivo and in vitro. This paper focused on Mn²⁺ and Cr³⁺doped nanostructures, particularly gallogermanates which are able to give intense red-near infrared persistent emission with a longer afterglow lifetime for more than two weeks and therefore are suitable for bioimaging application. The functionalized red-near infrared persistent luminescence nanomaterials provide a promising technology platform for long-term real-time detection of physiological processes and disease diagnosis in vivo. Finally, the challenges of PLNPs are described.

Contents
1 Introduction
2 Synthesis methods of PLNPs
2.1 Solid-State reaction
2.2 Sol-Gel method
2.3 Hydrothermal method
2.4 Co-Precipitation
2.5 Template method
2.6 Combustion method
2.7 Other methods
3 Application of PLNPs Nanoprobes in biomedicine
3.1 PLNPs based Biosensing and detection
3.2 PLNPs based Bioimaging
3.3 Multimodal Imaging of PLNPs
4 Conclusion and outlook

Graphical abstract

关键词

长余辉纳米探针(PLNPs) / 近红外(NIR) / 传感检测 / 生物成像

Key words

persistentence luminescence nanoprobe(PLNPs) / near infrared(NIR) / biosensing / bioimaging

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刘瑶瑶, 刘敬民, 方国臻, 张咚咚, 王青华, 王硕. 基于长余辉纳米发光探针的生物传感检测和成像[J]. 化学进展, 2017, 29(6): 667-682 DOI:10.7536/PC170301

Yaoyao Li, Jingmin Liu, Guozhen Fang, Dongdong Zhang, Qinghua Wang, Shuo Wang. Biosensor Detection and Imaging Based on Persistence Luminescence Nanoprobe[J]. Progress in Chemistry, 2017, 29(6): 667-682 DOI:10.7536/PC170301

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