多巴胺是存在于人体内的一种儿茶酚胺类神经递质。自从研究者们发现了利用多巴胺的氧化自聚合反应制备聚多巴胺涂层的简便方法之后，多巴胺基纳米材料已经发展成为一类新兴的生物材料。多巴胺基纳米材料由于具有独特的物理化学性质，例如普适性的粘附性质、高化学反应活性、优良的生物相容性和生物降解性、以及光热转换性质，而在生物传感、药物输送、光热疗法、抗菌和组织工程等领域吸引了研究者们强烈的研究兴趣。本文综述了多巴胺基纳米材料的制备、功能化及在生物医药应用方面的最新进展。首先介绍了几种典型的多巴胺基纳米材料，并讨论影响其组装过程的因素。之后详细综述了这些材料在生物医药领域的应用，尤其是在癌症诊断和治疗方面。最后，本文提出了推进多巴胺基纳米材料临床应用需要发展的研究方向。
Dopamine is a catecholamine that acts as an important neurotransmitter in the nervous system. Since the introduction of the simple preparation method of polydopamine with the oxidative self-polymerization of dopamine, dopamine based nanomaterials have emerged as the novel biomaterials. They have attracted considerable interests in the fields of biosensing, drug delivery, photothermal therapy, antimicrobials, and tissue engineering due to their unique physicochemical properties, such as versatile adhesion property, high chemical reactivity, excellent biocompatibility and biodegradability, and strong photothermal conversion capacity. This review summarizes the recent advances on the fabrication, functionalization, and biomedical applications of dopamine based nanomaterials. Firstly, several typical dopamine based nanomaterials are introduced with a discussion of the factors that influence the assembly process. Then detailed elaboration is followed on their applications in biomedical fields, especially in cancer diagnosis and therapy. Finally, the review proposes some research topics for clinical applications of dopamine based nanomaterials.
Contents
1 Introduction
2 Dopamine based nanomaterials
2.1 Nanoparticles
2.2 Microcapsules
2.3 Polydopamine films
2.4 Other materials
3 Biomedical applications
3.1 Biosensing
3.2 Bioimaging
3.3 Drug delivery
3.4 Photothermal therapy
3.5 Theranostics
3.6 Antimicrobials
3.7 Tissue engineering
4 Conclusion and perspective
[1] Bibb J A, Snyder G L, Nishi A, Yan Z, Meijer L, Fienberg A A, Tsai L H, Kwon Y T, Girault J A, Czernik A J, Huganir R L, Hemmings H C, Nairn A C, Greengard P. Nature, 1999, 402(6762):669.
[2] Carlsson A, Lindqvist M. Acta Physiol. Scand., 1962, 54:87.
[3] Huang H L, Wu K M, Ma J, Du Y L, Cao C Y, Nie Y Q. Int. Immunopharmacol., 2016, 39:113.
[4] Zhang Q B, Zhang B H, Zhang K Z, Meng X T, Jia Q A, Bu Y, Zhu X D, Ma D N, Ye B G, Zhang N, Ren Z G, Sun H C, Tang Z Y. Oncogene, 2016, 35(31):4122.
[5] Akbari M E, Kashani F L, Ahangari G, Pornour M, Hejazi H, Nooshinfar E, Kabiri M, Hosseini L. Breast Cancer, 2016, 23(6):901.
[6] Borcherding D C, Tong W, Hugo E R, Barnard D F, Fox S, LaSance K, Shaughnessy E, Ben-Jonathan N. Oncogene, 2016, 35(24):3103.
[7] Basu S, Nagy J A, Pal S, Vasile E, Eckelhoefer I A, Bliss V S, Manseau E J, Dasgupta P S, Dvorak H F, Mukhopadhyay D. Nat. Med., 2001, 7(5):569.
[8] Moreno-Smith M, Lu C, Shahzad M M K, Pena G N A, Allen J K, Stone R L, Mangala L S, Han H D, Kim H S, Farley D, Berestein G L, Cole S W, Lutgendorf S K, Sood A K. Clin. Cancer Res., 2011, 17(11):3649.
[9] Lee H, Dellatore S M, Miller W M, Messersmith P B. Science, 2007, 318(5849):426.
[10] Lynge M E, van der Westen R, Postma A, Stadler B. Nanoscale, 2011, 3(12):4916.
[11] Liu Y L, Ai K L, Lu L H. Chem. Rev., 2014, 114(9):5057.
[12] 赵晨旭(Zhao C X), 谢银红(Xie Y H), 廖芝建(Liao Z J), 秦振立(Qin Z L), 杜思南(Du S N), 左芳(Zuo F), 赵志刚(Zhao Z G). 高分子通报(Chinese Polymer Bulletin), 2015, 12(004):28.
[13] 廉成波(Lian C B), 郑爱隔(Zheng A G), 史新妍(Shi X Y). 合成橡胶工业(China Synthetic Rubber Industry), 2014, 37(4):327.
[14] Liu M Y, Zeng G J, Wang K, Wan Q, Tao L, Zhang X Y, Wei Y. Nanoscale, 2016, 8(38):16819.
[15] Batul R, Tamanna T, Khaliq A, Yu A. Biomater. Sci., 2017, 5(7):1204.
[16] Perikamana S K M, Lee J, Lee Y B, Shin Y M, Lee E J, Mikos A G, Shin H. Biomacromolecules, 2015, 16(9):2541.
[17] 刘宗光(Liu Z G), 屈树新(Qu S X), 翁杰(Weng J). 化学进展(Progress in Chemistry), 2015, 27(2/3):212.
[18] Liu Y L, Ai K L, Liu J H, Deng M, He Y Y, Lu L H. Adv. Mater., 2013, 25(9):1353.
[19] Xie Y, Lin X Y, Huang Y S, Pan R J, Zhu Z, Zhou L J, Yang C Y J. Chem. Commun., 2015, 51(11):2156.
[20] Wang Q, Yin B C, Ye B C. Biosens. Bioelectron., 2016, 80:366.
[21] Liu F Y, He X X, Zhang J P, Chen H D, Zhang H M, Wang Z X. J. Mater. Chem. B, 2015, 3(33):6731.
[22] Zheng Q S, Lin T R, Wu H Y, Guo L Q, Ye P R, Hao Y L, Guo Q Q, Jiang J Z, Fu F F, Chen G N. Int. J. Pharm., 2014, 463(1):22.
[23] Xiong W, Peng L X, Chen H B, Li Q. Int. J. Nanomed., 2015, 10:2985.
[24] Ju K Y, Lee S, Pyo J, Choo J, Lee J K. Small, 2015, 11(1):84.
[25] Wang S W, Zhao X Y, Wang S C, Qian J, He S L. ACS Appl. Mater. Interfaces, 2016, 8(37):24368.
[26] Lin Q K, Huang X J, Tang J M, Han Y M, Chen H. J. Nanopart. Res., 2013, 15(12):2144.
[27] Si J Y, Yang H. Mater. Chem. Phys., 2011, 128(3):519.
[28] Liu R, Guo Y L, Odusote G, Qu F L, Priestley R D. ACS Appl. Mater. Interfaces, 2013, 5(18):9167.
[29] Wu M, Zhang D, Zeng Y Y, Wu L J, Liu X L, Liu J F. Nanotechnology, 2015, 26(11):115102.
[30] Wu M, Wang Q T, Zhang D, Liao N S, Wu L J, Huang A M, Liu X L. Colloids Surf. B, 2016, 141:467.
[31] Xuan M J, Zhao J, Shao J X, Du C L, Cui W, Duan L, Qi W, Li J B. J. Colloid Interf. Sci., 2017, 487:107.
[32] Jia Y, Li J B. Chem. Rev., 2015, 115(3):1597.
[33] Feng X Y, Du C L, Li J B. Chem. Rec., 2016, 16(4):1991.
[34] Postma A, Yan Y, Wang Y J, Zelikin A N, Tjipto E, Caruso F. Chem. Mater., 2009, 21(14):3042.
[35] Chen X, Yan Y, Muellner M, van Koeverden M P, Noi K F, Zhu W, Caruso F. Langmuir, 2014, 30(10):2921.
[36] Liu Q, Yu B, Ye W C, Zhou F. Macromol. Biosci., 2011, 11(9):1227.
[37] Li H, Jia Y, Feng X Y, Li J B. J. Colloid Interf. Sci., 2017, 487:12.
[38] Zhang L, Shi J F, Jiang Z Y, Jiang Y J, Qiao S Z, Li J, Wang R, Meng R J, Zhu Y Y, Zheng Y. Green Chem., 2011, 13(2):300.
[39] Cui J W, Yan Y, Such G K, Liang K, Ochs C J, Postma A, Caruso F. Biomacromolecules, 2012, 13(8):2225.
[40] Yeroslavsky G, Richman M, Dawidowicz L O, Rahimipour S. Chem. Commun., 2013, 49(51):5721.
[41] Ni Y Z, Jiang W F, Tong G S, Chen J X, Wang J, Li H M, Yu C Y, Huang X H, Zhou Y F. Org. Biomol. Chem., 2015, 13(3):686.
[42] Jiang J H, Zhu L P, Zhu L J, Zhu B K, Xu Y Y. Langmuir, 2011, 27(23):14180.
[43] Tsai W B, Chen W T, Chien H W, Kuo W H, Wang M J. J. Biomater. Appl., 2014, 28(6):837.
[44] Shin Y M, Lee Y B, Kim S J, Kang J K, Park J C, Jang W, Shin H. Biomacromolecules, 2012, 13(7):2020.
[45] Wang X B, Miao J J, Xia Q, Yang K, Huang X H, Zhao W B, Shen J. Electrochim. Acta, 2013, 112:473.
[46] Zhang P, He M, Zeng Y. Lab on a Chip, 2016, 16(16):3033.
[47] Wu S J, Cai C C, Cheng J, Cheng M, Zhou H B, Deng J L. Anal. Chim. Acta, 2016, 935:113.
[48] Kohri M, Nannichi Y, Kohma H, Abe D, Kojima T, Taniguchi T, Kishikawa K. Colloids Surf. A, 2014, 449:114.
[49] Yu X, Fan H L, Wang L, Jin Z X. Angew. Chem. Int. Ed., 2014, 53(46):12600.
[50] Fan H L, Yu X, Liu Y, Shi Z J, Liu H H, Nie Z X, Wu D C, Jin Z X. Soft Matter, 2015, 11(23):4621.
[51] Ma S, Qi Y X, Jiang X Q, Chen J Q, Zhou Q Y, Shi G, Zhang M. Anal. Chem., 2016, 88(23):11647.
[52] Hong S, Schaber C F, Dening K, Appel E, Gorb S N, Lee H. Adv. Mater., 2014, 26(45):7581.
[53] Zhang Y, Thingholm B, Goldie K N, Ogaki R, Stadler B. Langmuir, 2012, 28(51):17585.
[54] Li H, Jia Y, Wang A H, Cui W, Ma H C, Feng X Y, Li J B. Chem. Eur. J., 2014, 20(2):499.
[55] Liu J Y, Wang J, Wang T S, Li D, Xi F N, Wang J, Wang E K. Biosens. Bioelectron., 2015, 65:281.
[56] Egeblad M, Werb Z. Nat. Rev. Cancer, 2002, 2(3):161.
[57] Zhu L, Kate P, Torchilin V P. ACS Nano, 2012, 6(4):3491.
[58] Yang G H, Li L L, Rana R K, Zhu J J. Carbon, 2013, 61:357.
[59] Tang X, Bansaruntip S, Nakayama N, Yenilmez E, Chang Y L, Wang Q. Nano Lett., 2006, 6(8):1632.
[60] He S J, Song B, Li D, Zhu C F, Qi W P, Wen Y Q, Wang L H, Song S P, Fang H P, Fan C H. Adv. Funct. Mater., 2010, 20(3):453.
[61] Qiang W B, Li W, Li X B, Chen X, Xu D K. Chem. Sci., 2014, 5(8):3018.
[62] Liu Q, Pu Z H, Asiri A M, Al-Youbi A O, Sun X P. Sensor. Actuat. B Chem., 2014, 191:567.
[63] Wang D, Chen C, Ke X B, Kang N, Shen Y Q, Liu Y L, Zhou X, Wang H J, Chen C Q, Ren L. ACS Appl. Mater. Interfaces, 2015, 7(5):3030.
[64] Chandra S, Das P, Bag S, Laha D, Pramanik P. Nanoscale, 2011, 3(4):1533.
[65] Yan L L, Zhang Y, Xu B, Tian W J. Nanoscale, 2016, 8(5):2471.
[66] Zhang X Y, Wang S Q, Xu L X, Feng L, Ji Y, Tao L, Li S X, Wei Y. Nanoscale, 2012, 4(18):5581.
[67] Kircher M F, de la Zerda A, Jokerst J V, Zavaleta C L, Kempen P J, Mittra E, Pitter K, Huang R, Campos C, Habte F, Sinclair R, Brennan C W, Mellinghoff I K, Holland E C, Gambhir S S. Nat. Med., 2012, 18(5):829.
[68] Ju K Y, Lee J W, Im G H, Lee S, Pyo J, Park S B, Lee J H, Lee J K. Biomacromolecules, 2013, 14(10):3491.
[69] Huang Z W, Lui H, Chen X K, Alajlan A, McLean D I, Zeng H S. J. Biomed. Opt., 2004, 9(6):1198.
[70] Popat A, Ross B P, Liu J, Jambhrunkar S, Kleitz F, Qiao S Z. Angew. Chem. Int. Ed., 2012, 51(50):12486.
[71] Ho C C, Ding S J. J. Mater. Sci. Mater. Med., 2013, 24(10):2381.
[72] Zhan H L, Jagtiani T, Liang J F. Eur. J. Pharm. Biopharm., 2017, 114:221.
[73] Zong W, Hu Y, Su Y C, Luo N, Zhang X N, Li Q C, Han X J. J. Microencapsul., 2016, 33(3):257.
[74] Xu G J, Yu X H, Zhang J X, Sheng Y C, Liu G, Tao W, Mei L. Int. J. Nanomed., 2016, 11:2953.
[75] Tao W, Zeng X W, Wu J, Zhu X, Yu X H, Zhang Y, Zhang J X, Liu G, Mei L. Theranostics, 2016, 6(4):470.
[76] Hashemi-Moghaddam H, Kazemi-Bagsangani S, Jamili M, Zavareh S. Int. J. Pharmaceut., 2016, 497(1/2):228.
[77] Zavareh S, Mahdi M, Erfanian S, Hashemi-Moghaddam H. Cancer Chemoth. Pharm., 2016, 78(5):1073.
[78] Xue J H, Zheng W C, Wang L, Jin Z X. ACS Biomater. Sci. Eng., 2016, 2(4):489.
[79] Tang W T, Liu B, Wang S P, Liu T L, Fu C H, Ren X L, Tan L F, Duan W B, Meng X W. RSC Adv., 2016, 6(39):32434.
[80] Dai Y L, Xu C, Sun X L, Chen X Y. Chem. Soc. Rev., 2017, 46(12):3830.
[81] Ghavami-Nejad A, Sasikala A R K, Unnithan A R, Thomas R G, Jeong Y Y, Vatankhah-Varnoosfaderani M, Stadler F J, Park C H, Kim C S. Adv. Funct. Mater., 2015, 25(19):2867.
[82] Sasikala A R K, GhavamiNejad A, Unnithan A R, Thomas R G, Moon M, Jeong Y Y, Park C H, Kim C S. Nanoscale, 2015, 7(43):18119.
[83] Chaturvedi K, Ganguly K, Nadagouda M N, Aminabhavi T M. J. Control. Release, 2013, 165(2):129.
[84] Wang D D, Wu H H, Zhou J J, Xu P P, Wang C L, Shi R H, Wang H B, Wang H, Guo Z, Chen Q W. Adv. Sci., 2018, 5:1800287.
[85] Ding W, Chechetka S A, Masuda M, Shimizu T, Aoyagi M, Minamikawa H, Miyako E. Chem. Eur J., 2016, 22(13):4345.
[86] Yu J, Lin Y H, Yang L, Huang C C, Chen L, Wang W C, Chen G W, Yan J, Sawettanun S, Lin C H. Adv. Healthcare Mater., 2017, 6(2):1600804.
[87] Zheng R, Wang S, Tian Y, Jiang X G, Fu D L, Shen S, Yang W L. ACS Appl. Mater. Interfaces, 2015, 7(29):15876.
[88] Ding Y, Su S, Zhang R, Shao L, Zhang Y, Wang B, Li Y, Chen L, Yu Q, Wu Y, Nie G. Biomaterials, 2017, 113:243.
[89] Zhang R R, Su S S, Hu K L, Shao L H, Deng X W, Sheng W, Wu Y. Nanoscale, 2015, 7(46):19722.
[90] Wu X J, Zhou L Z, Su Y, Dong C M. Polym. Chem., 2016, 7(35):5552.
[91] GhavamiNejad A, SamariKhalaj M, Aguilar L E, Park C H, Kim C S. Sci. Rep., 2016, 6:33594.
[92] Kim S H, Sharker S M, Lee H, In I, Lee K D, Park S Y. RSC Adv., 2016, 6(66):61482.
[93] Li Y, Zhang X Y, Zheng M, Liu S, Xie Z G. RSC Adv., 2016, 6(59):54087.
[94] Li D, Zhang Y X, Wen S H, Song Y, Tang Y Q, Zhu X Y, Shen M W, Mignani S, Majoral J, Zhao Q H, Shi X Y. J. Mater. Chem. B, 2016, 4(23):4216.
[95] Liu B, Li C X, Xing B G, Yang P P, Lin J. J. Mater. Chem. B, 2016, 4(28):4884.
[96] Zhao H, Chao Y, Liu J J, Huang J, Pan J, Guo W L, Wu J Z, Sheng M, Yang K, Wang J, Liu Z. Theranostics, 2016, 6(11):1833.
[97] Cho S, Park W, Kim D H. ACS Appl. Mater. Interfaces, 2017, 9(1):101.
[98] Chen Y, Ai K L, Liu J H, Ren X Y, Jiang C H, Lu L H. Biomaterials, 2016, 77:198.
[99] Dong Z L, Gong H, Gao M, Zhu W W, Sun X Q, Feng L Z, Fu T T, Li Y G, Liu Z. Theranostics, 2016, 6(7):1031.
[100] Lin L S, Cong Z X, Cao J B, Ke K M, Peng Q L, Gao J, Yang H H, Liu G, Chen X. ACS Nano, 2014, 8(4):3876.
[101] Li Y Y, Jiang C H, Zhang D W, Wang Y, Ren X Y, Ai K L, Chen X S, Lu L H. Acta Biomater., 2017, 47:124.
[102] Zhang M, Peltier R, Zhang M M, Lu H J, Bian H D, Li Y Y, Xu Z T, Shen Y J, Sun H Y, Wang Z K. J. Mater. Chem. B, 2017, 5(27):5311.
[103] Li H, Yan Y L, Gu X F, Jiao L, Peng H N, Cui W. Colloids Surf. A, 2018, 538:513.
[104] Jiang J H, Zhu L P, Zhu L J, Zhang H T, Zhu B K, Xu Y Y. ACS Appl. Mater. Interfaces, 2013, 5(24):12895.
[105] Su L, Yu Y, Zhao Y S, Liang F, Zhang X J. Sci. Rep., 2016, 6:24420.
[106] Iqbal Z, Lai E P C, Avis T J. J. Mater. Chem., 2012, 22(40):21608.
[107] Yang K, Lee J S, Kim J, Lee Y B, Shin H, Um S H, Kim J B, Park K I, Lee H, Cho S W. Biomaterials, 2012, 33(29):6952.
[108] Lee S J, Lee D, Yoon T R, Kim H K, Jo H H, Park J S, Lee J H, Kim W D, Kwon I K, Park S A. Acta Biomater., 2016, 40:182.
PDF
(7036KB)
