基于六种关键翻译后修饰的乳腺癌肿瘤标志物研究

周春花; 马建峰; 郑淑珍

doi:10.7536/PC20260211

化学进展 ›› :0- DOI: 10.7536/PC20260211

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基于六种关键翻译后修饰的乳腺癌肿瘤标志物研究

周春花 ¹ ,
马建峰 ¹^,² ,
郑淑珍 ¹^,^*

作者信息 +

ChunHua Zhou ¹ ,
Jianfeng Ma ¹^,² ,
Shuzhen Zheng ¹^,^*

Author information +

文章历史 +

摘要

乳腺癌是全球高发恶性肿瘤之一，约20%~30%的晚期患者会发生远处器官转移，现有治疗手段难以实现根治。肿瘤标志物的挖掘与靶向干预是乳腺癌诊断与治疗研究的前沿热点，而蛋白质翻译后修饰（PTMs）的动态调控，已成为发掘乳腺癌新型诊断生物标志物与治疗药物靶点的重要途径。目前，磷酸化、甲基化、棕榈酰化、乙酰化等经典PTM的乳腺癌相关研究已较为深入，乳酰化、糖基化等新兴修饰类型也逐渐成为领域研究热点。本文系统综述了乳腺癌中六种主要PTM的类型特征、调控机制及其相关研究进展，重点剖析了PTM在乳腺癌生物标志物（如HDAC2、SIRT7、BRD4）与关键研究靶点（PIM2、KAT2B、ATAT1、RAD51、KLRB1、KLF5、PRMT5）中的调控作用。这些靶点可通过调控细胞增殖、迁移与侵袭、糖代谢及耐药等恶性生物学行为，参与乳腺癌的发生发展进程。通过系统研究乳腺癌中PTM的分子调控机制，可为乳腺癌早期精准诊断、个体化治疗及预后评估提供新思路与理论依据，也为后续相关研究奠定理论基础。

Abstract

Breast cancer is one of the most prevalent malignant tumors worldwide, with approximately 20%-30% of patients in advanced stages developing distant organ metastasis, rendering radical cure difficult with existing treatment modalities. The discovery of tumor biomarkers and targeted interventions represents a frontier focus in breast cancer diagnosis and therapy research. In this context, the dynamic regulation of protein post-translational modifications (PTMs) has emerged as a critical avenue for identifying novel diagnostic biomarkers and therapeutic drug targets for breast cancer. To date, research on classical PTM such as phosphorylation, methylation, palmitoylation, and acetylation in breast cancer has been relatively well established, while emerging modification types including lactylation and glycosylation are increasingly becoming research hotspots. This article systematically reviews the type characteristics, regulatory mechanisms, and research progress of six major PTM in breast cancer, with a particular emphasis on their regulatory roles in breast cancer biomarkers (e.g., HDAC2, SIRT7, BRD4) and key research targets (e.g., PIM2, KAT2B, ATAT1, RAD51, KLRB1, KLF5, PRMT5). These targets participate in breast cancer initiation and progression by modulating malignant biological behaviors such as cell proliferation, migration and invasion, glucose metabolism, and drug resistance. Systematic investigation of the molecular regulatory mechanisms of PTM in breast cancer may provide new insights and theoretical foundations for early precise diagnosis, personalized therapy, and prognostic evaluation of breast cancer, thereby laying a theoretical groundwork for subsequent related studies.

关键词

乳腺癌 / 磷酸化 / 乙酰化 / 乳酰化 / 糖基化 / 棕榈酰化 / 甲基化

Key words

breast cancer / phosphorylation / acetylation / lactylation / glycosylation / palmitoylation / methylation

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周春花, 马建峰, 郑淑珍. 基于六种关键翻译后修饰的乳腺癌肿瘤标志物研究[J]. 化学进展, , (): 0 DOI:10.7536/PC20260211

ChunHua Zhou, Jianfeng Ma, Shuzhen Zheng. Progress in Chemistry 0 DOI:10.7536/PC20260211

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