半导体-微生物杂化界面的能量转换：进展与展望

吴沛航; 杨江花; 李艳红; 张淑娟

doi:10.7536/PC20260212

化学进展 ›› :0--1 DOI: 10.7536/PC20260212

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半导体-微生物杂化界面的能量转换：进展与展望

吴沛航 ¹^,² ,
杨江花 ²^,^* ,
李艳红 ¹ ,
张淑娟 ²

作者信息 +

Peihang Wu ¹^,² ,
Jianghua Yang ²^,^* ,
Yanhong Li ¹ ,
Shujuan Zhang ²

Author information +

文章历史 +

摘要

在自然光合体系中，微生物通过依赖于氧化还原反应的精密电子传递网络，将太阳能转化为维持生命活动的化学能。受此启发，半人工光合作用致力于构筑半导体-微生物杂化体系，旨在非生物的半导体材料与微生物的代谢网络之间构建一条高效可控的“电子高速公路”，从而将这一生命本质过程拓展为可持续的能源与物质转化平台。尽管已有综述对基于全细胞的材料-微生物杂化体系及其太阳能-化学能转化机制进行了广泛探讨，然而，在如何理性优化材料-微生物界面的电子传递路径与能量传输耦合等核心科学问题上，仍存在显著的知识缺口。这些相互关联的要素从根本上决定了杂化体系的整体效率、稳定性及规模化潜力。为填补上述空白，本综述聚焦于光驱动生物杂化体系的界面工程这一关键议题，系统梳理了以下方面的最新进展：跨界面电子传递路径的理性设计及界面稳定性调控与能量协同转化策略，并批判性评估了当前光驱动生物杂化体系界面构筑面临的主要挑战。在此基础上，我们提出了前瞻性的研究方向，以期推动该领域向高效、稳定、可规模化的新一代体系演进。

Abstract

In natural photosynthetic systems, microbe convert solar energy into chemical energy to sustain life activities through sophisticated electron transfer networks that rely on redox reactions. Inspired by this, semi-artificial photosynthesis aims to construct semiconductor-microbe hybrid systems, seeking to establish an efficient and controllable “electron highway” between abiotic semiconductor materials and the metabolic networks of microorganisms, thereby extending this intrinsic life process into a sustainable platform for energy and matter conversion. Although existing reviews have extensively discussed whole-cell-based material-microbe hybrid systems and their solar-to-chemical energy conversion mechanisms, a significant knowledge gap remains regarding core scientific issues such as how to rationally optimize the electron transfer pathways and energy transfer coupling at the material-microbe interface. These interrelated factors fundamentally determine the overall efficiency, stability, and scalability potential of hybrid systems. To address this gap, this review focuses on the pivotal issue of interface engineering in solar-driven biohybrid systems. It systematically outlines recent advances in the rational design of cross-interface electron transfer pathways, regulation of interface stability, and strategies for synergistic energy conversion, while critically assessing the major challenges currently confronting the construction of interfaces in solar-driven biohybrid systems. Based on this assessment, we propose forward-looking research directions aimed at advancing the evolution of next-generation systems toward enhanced efficiency, stability, and scalability.

关键词

半人工光合作用 / 界面工程 / 非生物-生物界面电子转移 / 界面调控与能量转换 / 可持续化学合成

Key words

Semi-artificial photosynthesis / Interfacial engineering / Abiotic-biotic interfacial electron transfer / Interfacial regulation and energy conversion / Sustainable chemical synthesis

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吴沛航, 杨江花, 李艳红, 张淑娟. 半导体-微生物杂化界面的能量转换：进展与展望[J]. 化学进展, , (): 0--1 DOI:10.7536/PC20260212

Peihang Wu, Jianghua Yang, Yanhong Li, Shujuan Zhang. Progress in Chemistry 0--1 DOI:10.7536/PC20260212

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参考文献

原文顺序 | 出版日期 | 本文引用

[1]	Farghali M, Osman AI, Mohamed IMA, Chen Z, Chen L, Ihara I. Environ. Chem. Lett. , 2023, 21: 2003- 39.

[2]	Campa MF, Brown CM, Byrley P, Delborne J, Glavin N, Green Cl. Nat. Nanotechnol. , 2024, 19: 1422- 6.

[3]	Lv J, Xie J, Mohamed AGA, Zhang X, Feng Y, Jiao L. Nat. Rev. Chem., 2023, 7: 91- 105.

[4]	Najafpour MM, Shen J-R, Allakhverdiev SI. Photosynth. Res., 2022, 154: 229- 31.

[5]	Reyes Cruz EA, Nishiori D, Wadsworth BL, Nguyen NP, Hensleigh LK, Khusnutdinova D. Chem. Rev., 2022, 122: 16051- 109.

[6]	Zhang B, Sun L. Chem. Soc. Rev., 2019,48: 2216- 64.

[7]	Xiao K, Liang J, Wang X, Hou T, Ren X, Yin P. Energy Environ. Sci., 2022, 15: 529- 49.

[8]	Okoro G, Husain S, Saukani M, Mutalik C, Yougbaré S, Hsiao Y-Cl. ACS Mater. Lett., 2023, 5: 95- 115.

[9]	Cestellos-Blanco S, Zhang H, Kim JM, Shen Y-x, Yang P. Nat. Catal., 2020, 3: 245- 55.

[10]	Krasnovsky AA, Nikandrov VV. FEBS Lett. , 1987, 219: 93- 6.

[11]	Sakimoto KK, Wong AB, Yang P. Science, 2016, 351: 74- 7.

[12]	Bai R, Chen W, Zhou X, Li J, He Y, Xiao Y. Chem. Eng. J., 2025, 520: 165819.

[13]	Bai R, Li J, Chen W, He Y, Zhou X, Tian X. Sci. China Chem., 2025, 68: 3200- 10.

[14]	Fang X, Kalathil S, Reisner E. Chem. Soc. Rev., 2020, 49: 4926- 4952.

[15]	Shen J, Liu Y, Qiao L. ACS Appl. Mater. Interfaces, 2023, 15: 6235- 59.

[16]	Zhang W, Xiong C, Chen P, Fu B, Mao X. J. Am. Chem. Soc., 2025, 147: 20171- 88.

[17]	Zhou X, Zeng Y, Lv F, Bai H, Wang S. Acc. Chem. Res., 2022, 55: 156- 70.

[18]	Guo J, Suástegui M, Sakimoto KK, Moody VM, Xiao G, Nocera DG. Science. , 2018, 362: 813- 6.

[19]	Chen M-Y, Fang Z, Xu L-X, Zhou D, Yang X-J, Zhu H-J. Bioresources and Bioprocessing. 2021, 8: 30.

[20]	Liang J, Xiao K, Wang X, Hou T, Zeng C, Gao X. Chem. Rev., 2024, 124: 9081- 112.

[21]	Ji W, Liu J, Sha C, Yong Y-C, Jiang Y, Fang Z. Green Carbon., 2024, 2: 322- 36.

[22]	Fang X, Kalathil S, Reisner E. Chem. Soc. Rev., 2020, 49: 4926- 52.

[23]	Kumar A, Hsu LH-H, Kavanagh P, Barrière F, Lens PNL, Lapinsonnière L. Nat. Rev. Chem., 2017, 1: 0024.

[24]	Wen X, Long X, Huang W, Kuramochi M, Okamoto A. J. Am. Chem. Soc., 2025, 147: 46932- 40.

[25]	Liang G, Gao C, Wu J, Hu G, Li X, Liu L. Bioresour. Technol., 2025, 428: 132445.

[26]	Lovley DR. Curr. Opin. Electrochem., 2017, 4: 190- 8.

[27]	Sartorio MG, Pardue EJ, Feldman MF, Haurat MF. Annu. Rev. Microbiol., 2021, 75: 609- 30.

[28]	Gralnick JA, Bond DR. Annu. Rev. Microbiol., 2023, 77: 517- 39.

[29]	Martins M, Toste C, Pereira IAC. Angew. Chem., Int. Ed., 2021, 60: 9055- 62.

[30]	Yu W, Pavliuk MV, Liu A, Zeng Y, Xia S, Huang Y. ACS Appl. Mater. Interfaces, 2023, 15: 2183- 91.

[31]	Tong T, Chen X, Tang K, Ma W, Gao C, Song W. Nat. Commun., 2025, 16: 145.

[32]	Wang R, Li H, Sun J, Zhang L, Jiao J, Wang Q. Adv. Mater., 2021, 33: 2004051.

[33]	Huo N, Li X, Xu Y, Ren C, Yan W, Tian X. ChemElectroChem. , 2024, 11:e202300785.

[34]	Pan Q, Tian X, Li J, Wu X, Zhao F. Appl. Energy, 2021, 292: 116885.

[35]	Ye J, Chen Y, Gao C, Wang C, Hu A, Dong G. Angew. Chem., Int. Ed., 2022, 61:e202213244.

[36]	Han GH, Bang J, Park G, Choe S, Jang YJ, Jang HW. Small, 2023, 19: 2205765.

[37]	Dong Q, Zhang X, He D, Lang C, Wang D. ACS Cent. Sci., 2019, 5: 1461- 7.

[38]	Wang Y, Liu J, Wang Y, Al-Enizi AM, Zheng G. Small, 2017, 13: 1701809.

[39]	Ezraty B, Gennaris A, Barras F, Collet J-F. Nat. Rev. Microbiol., 2017, 15: 385- 96.

[40]	Ziegelhoffer EC, Donohue TJ. Nat. Rev. Microbiol., 2009, 7: 856- 63.

[41]	Nosaka Y, Nosaka AY. Chem. Rev., 2017, 117: 11302- 36.

[42]	Sun Y, Han L, Strasser P. Chem. Soc. Rev., 2020, 49: 6605- 31.

[43]	Fu H, Yuan J, Gao H. Arch. Biochem. Biophys., 2015, 584: 28- 35.

[44]	Chen X, Feng Q, Cai Q, Huang S, Yu Y, Zeng RJ. Environ. Sci. Technol., 2020, 54: 10820- 30.

[45]	Yuan Y, Conrad R, Lu Y. Environ. Microbiol. Rep., 2009, 1: 347- 54.

[46]	Ljungdahl LG. Annu. Rev. Microbiol., 2009, 63: 1- 25.

[47]	Ramprakash B, Incharoensakdi A. Bioresour. Technol., 2023, 388: 129703.

[48]	Xu Z, Qi J, Wang S, Liu X, Li M, Mann S. Nat. Commun., 2023, 14: 1872.

[49]	Wei W, Sun P, Li Z, Song K, Su W, Wang B. Sci. Adv., 2018, 4:eaap9253.

[50]	Ji Z, Zhang H, Liu H, Yaghi OM, Yang P. Proc. Natl. Acad. Sci., 2018, 115: 10582- 7.

[51]	Wang Y, Liu Y, Zhao N, Wang J, Yang Y, Cui D. Biotechnol. J., 2023, 18: 2300084.

[52]	Gu W, Hu J, Li L, Hong M, Yang C, Ren Gl. Environ. Sci. Technol., 2024, 58: 20434- 43.

[53]	Oh J, Kumari N, Kim D, Kumar A, Lee IS. Nat. Commun. , 2024, 15: 5773.

[54]	Wang X, Zhang J, Li K, An B, Wang Y, Zhong C. Sci. Adv. , 2022, 8:eabm7665.

[55]	Yu Y-Y, Wang Y-Z, Fang Z, Shi Y-T, Cheng Q-W, Chen Y-X. Nat. Commun. , 2020, 11: 4087.

[56]	Wang X-M, Chen L, Liu T, Guo Z-Y, Wang Z-Y, Teng L. ACS ES&T Eng. , 2025, 5: 932- 41.

[57]	Labarile R, Vona D, Varsalona M, Grattieri M, Reggente M, Comparelli R. Nano Res. , 2024, 17: 875- 81.

[58]	Dai Y, Wai S, Li P, Shan N, Cao Z, Li Y. Sci. , 2024, 386: 431- 9.

[59]	Sun J, Feng Y, Zheng R, Mao Y, Zhu Q, Wu X. Nat. Sustain. , 2025, 8: 1048- 57.

[60]	Fang Y, Yuan B, Jiang Y, Song R-B, Zhang J-R, Zhu J-J. J. Mater. Chem. A, 2022, 10: 4915- 25.

[61]	Dai Y, Wai S, Li P, Shan N, Cao Z, Li Y. Science. , 2024, 386: 431- 9.

[62]	Xu N, Zhang X, Guo P-C, Xie D-H, Sheng G-P. Sci. Adv. , 2024, 10:eadp2179.

[63]	Hu J, Chen M, Gu W, Deng W, Hong M, Hu A. Sci. China: Technol. Sci. , 2024, 67: 3051- 66.

[64]	Liu K, Yuan C, Zou Q, Xie Z, Yan X. Angew. Chem., Int. Ed. , 2017, 56: 7984- 8.

[65]	Zhang S, Shi J, Sun Y, Wu Y, Zhang Y, Cai Z. ACS Catal. , 2019, 9: 3913- 25.

[66]	Jia J, Huo Q, Yang D, Sun Y, Zhang S, Li S. ACS Catal. , 2021, 11: 9210- 20.

[67]	Inoue K, Karasuyama M, Nakamura R, Konno M, Yamada D, Mannen K. Commun. Biol. , 2021, 4: 362.

[68]	Hu G, Li Z, Ma D, Ye C, Zhang L, Gao C. Nat. Catal. , 2021, 4: 395- 406.

[69]	Chen N, Shen R, He T, Xi J, Zhao R, Du N. Angew. Chem.,Int. Ed. , 2025, 64:e202414981.

[70]	Chen N, Xi J, He T, Shen R, Zhao R, Chi H. Chem. , 2025, 11: 102381.

[71]	Zhang H, Liu H, Tian Z, Lu D, Yu Y. Nat. Nanotechnol. , 2018, 13: 900- 5.

[1]	Farghali M, Osman AI, Mohamed IMA, Chen Z, Chen L, Ihara I. Environ. Chem. Lett. , 2023, 21: 2003- 39.
[2]	Campa MF, Brown CM, Byrley P, Delborne J, Glavin N, Green Cl. Nat. Nanotechnol. , 2024, 19: 1422- 6.
[3]	Lv J, Xie J, Mohamed AGA, Zhang X, Feng Y, Jiao L. Nat. Rev. Chem., 2023, 7: 91- 105.
[4]	Najafpour MM, Shen J-R, Allakhverdiev SI. Photosynth. Res., 2022, 154: 229- 31.
[5]	Reyes Cruz EA, Nishiori D, Wadsworth BL, Nguyen NP, Hensleigh LK, Khusnutdinova D. Chem. Rev., 2022, 122: 16051- 109.
[6]	Zhang B, Sun L. Chem. Soc. Rev., 2019,48: 2216- 64.
[7]	Xiao K, Liang J, Wang X, Hou T, Ren X, Yin P. Energy Environ. Sci., 2022, 15: 529- 49.
[8]	Okoro G, Husain S, Saukani M, Mutalik C, Yougbaré S, Hsiao Y-Cl. ACS Mater. Lett., 2023, 5: 95- 115.
[9]	Cestellos-Blanco S, Zhang H, Kim JM, Shen Y-x, Yang P. Nat. Catal., 2020, 3: 245- 55.
[10]	Krasnovsky AA, Nikandrov VV. FEBS Lett. , 1987, 219: 93- 6.
[11]	Sakimoto KK, Wong AB, Yang P. Science, 2016, 351: 74- 7.
[12]	Bai R, Chen W, Zhou X, Li J, He Y, Xiao Y. Chem. Eng. J., 2025, 520: 165819.
[13]	Bai R, Li J, Chen W, He Y, Zhou X, Tian X. Sci. China Chem., 2025, 68: 3200- 10.
[14]	Fang X, Kalathil S, Reisner E. Chem. Soc. Rev., 2020, 49: 4926- 4952.
[15]	Shen J, Liu Y, Qiao L. ACS Appl. Mater. Interfaces, 2023, 15: 6235- 59.
[16]	Zhang W, Xiong C, Chen P, Fu B, Mao X. J. Am. Chem. Soc., 2025, 147: 20171- 88.
[17]	Zhou X, Zeng Y, Lv F, Bai H, Wang S. Acc. Chem. Res., 2022, 55: 156- 70.
[18]	Guo J, Suástegui M, Sakimoto KK, Moody VM, Xiao G, Nocera DG. Science. , 2018, 362: 813- 6.
[19]	Chen M-Y, Fang Z, Xu L-X, Zhou D, Yang X-J, Zhu H-J. Bioresources and Bioprocessing. 2021, 8: 30.
[20]	Liang J, Xiao K, Wang X, Hou T, Zeng C, Gao X. Chem. Rev., 2024, 124: 9081- 112.
[21]	Ji W, Liu J, Sha C, Yong Y-C, Jiang Y, Fang Z. Green Carbon., 2024, 2: 322- 36.
[22]	Fang X, Kalathil S, Reisner E. Chem. Soc. Rev., 2020, 49: 4926- 52.
[23]	Kumar A, Hsu LH-H, Kavanagh P, Barrière F, Lens PNL, Lapinsonnière L. Nat. Rev. Chem., 2017, 1: 0024.
[24]	Wen X, Long X, Huang W, Kuramochi M, Okamoto A. J. Am. Chem. Soc., 2025, 147: 46932- 40.
[25]	Liang G, Gao C, Wu J, Hu G, Li X, Liu L. Bioresour. Technol., 2025, 428: 132445.
[26]	Lovley DR. Curr. Opin. Electrochem., 2017, 4: 190- 8.
[27]	Sartorio MG, Pardue EJ, Feldman MF, Haurat MF. Annu. Rev. Microbiol., 2021, 75: 609- 30.
[28]	Gralnick JA, Bond DR. Annu. Rev. Microbiol., 2023, 77: 517- 39.
[29]	Martins M, Toste C, Pereira IAC. Angew. Chem., Int. Ed., 2021, 60: 9055- 62.
[30]	Yu W, Pavliuk MV, Liu A, Zeng Y, Xia S, Huang Y. ACS Appl. Mater. Interfaces, 2023, 15: 2183- 91.
[31]	Tong T, Chen X, Tang K, Ma W, Gao C, Song W. Nat. Commun., 2025, 16: 145.
[32]	Wang R, Li H, Sun J, Zhang L, Jiao J, Wang Q. Adv. Mater., 2021, 33: 2004051.
[33]	Huo N, Li X, Xu Y, Ren C, Yan W, Tian X. ChemElectroChem. , 2024, 11:e202300785.
[34]	Pan Q, Tian X, Li J, Wu X, Zhao F. Appl. Energy, 2021, 292: 116885.
[35]	Ye J, Chen Y, Gao C, Wang C, Hu A, Dong G. Angew. Chem., Int. Ed., 2022, 61:e202213244.
[36]	Han GH, Bang J, Park G, Choe S, Jang YJ, Jang HW. Small, 2023, 19: 2205765.
[37]	Dong Q, Zhang X, He D, Lang C, Wang D. ACS Cent. Sci., 2019, 5: 1461- 7.
[38]	Wang Y, Liu J, Wang Y, Al-Enizi AM, Zheng G. Small, 2017, 13: 1701809.
[39]	Ezraty B, Gennaris A, Barras F, Collet J-F. Nat. Rev. Microbiol., 2017, 15: 385- 96.
[40]	Ziegelhoffer EC, Donohue TJ. Nat. Rev. Microbiol., 2009, 7: 856- 63.
[41]	Nosaka Y, Nosaka AY. Chem. Rev., 2017, 117: 11302- 36.
[42]	Sun Y, Han L, Strasser P. Chem. Soc. Rev., 2020, 49: 6605- 31.
[43]	Fu H, Yuan J, Gao H. Arch. Biochem. Biophys., 2015, 584: 28- 35.
[44]	Chen X, Feng Q, Cai Q, Huang S, Yu Y, Zeng RJ. Environ. Sci. Technol., 2020, 54: 10820- 30.
[45]	Yuan Y, Conrad R, Lu Y. Environ. Microbiol. Rep., 2009, 1: 347- 54.
[46]	Ljungdahl LG. Annu. Rev. Microbiol., 2009, 63: 1- 25.
[47]	Ramprakash B, Incharoensakdi A. Bioresour. Technol., 2023, 388: 129703.
[48]	Xu Z, Qi J, Wang S, Liu X, Li M, Mann S. Nat. Commun., 2023, 14: 1872.
[49]	Wei W, Sun P, Li Z, Song K, Su W, Wang B. Sci. Adv., 2018, 4:eaap9253.
[50]	Ji Z, Zhang H, Liu H, Yaghi OM, Yang P. Proc. Natl. Acad. Sci., 2018, 115: 10582- 7.
[51]	Wang Y, Liu Y, Zhao N, Wang J, Yang Y, Cui D. Biotechnol. J., 2023, 18: 2300084.
[52]	Gu W, Hu J, Li L, Hong M, Yang C, Ren Gl. Environ. Sci. Technol., 2024, 58: 20434- 43.
[53]	Oh J, Kumari N, Kim D, Kumar A, Lee IS. Nat. Commun. , 2024, 15: 5773.
[54]	Wang X, Zhang J, Li K, An B, Wang Y, Zhong C. Sci. Adv. , 2022, 8:eabm7665.
[55]	Yu Y-Y, Wang Y-Z, Fang Z, Shi Y-T, Cheng Q-W, Chen Y-X. Nat. Commun. , 2020, 11: 4087.
[56]	Wang X-M, Chen L, Liu T, Guo Z-Y, Wang Z-Y, Teng L. ACS ES&T Eng. , 2025, 5: 932- 41.
[57]	Labarile R, Vona D, Varsalona M, Grattieri M, Reggente M, Comparelli R. Nano Res. , 2024, 17: 875- 81.
[58]	Dai Y, Wai S, Li P, Shan N, Cao Z, Li Y. Sci. , 2024, 386: 431- 9.
[59]	Sun J, Feng Y, Zheng R, Mao Y, Zhu Q, Wu X. Nat. Sustain. , 2025, 8: 1048- 57.
[60]	Fang Y, Yuan B, Jiang Y, Song R-B, Zhang J-R, Zhu J-J. J. Mater. Chem. A, 2022, 10: 4915- 25.
[61]	Dai Y, Wai S, Li P, Shan N, Cao Z, Li Y. Science. , 2024, 386: 431- 9.
[62]	Xu N, Zhang X, Guo P-C, Xie D-H, Sheng G-P. Sci. Adv. , 2024, 10:eadp2179.
[63]	Hu J, Chen M, Gu W, Deng W, Hong M, Hu A. Sci. China: Technol. Sci. , 2024, 67: 3051- 66.
[64]	Liu K, Yuan C, Zou Q, Xie Z, Yan X. Angew. Chem., Int. Ed. , 2017, 56: 7984- 8.
[65]	Zhang S, Shi J, Sun Y, Wu Y, Zhang Y, Cai Z. ACS Catal. , 2019, 9: 3913- 25.
[66]	Jia J, Huo Q, Yang D, Sun Y, Zhang S, Li S. ACS Catal. , 2021, 11: 9210- 20.
[67]	Inoue K, Karasuyama M, Nakamura R, Konno M, Yamada D, Mannen K. Commun. Biol. , 2021, 4: 362.
[68]	Hu G, Li Z, Ma D, Ye C, Zhang L, Gao C. Nat. Catal. , 2021, 4: 395- 406.
[69]	Chen N, Shen R, He T, Xi J, Zhao R, Du N. Angew. Chem.,Int. Ed. , 2025, 64:e202414981.
[70]	Chen N, Xi J, He T, Shen R, Zhao R, Chi H. Chem. , 2025, 11: 102381.
[71]	Zhang H, Liu H, Tian Z, Lu D, Yu Y. Nat. Nanotechnol. , 2018, 13: 900- 5.