Selenoprotein M and Its Effects on Diseases

Chen Ping; Jiang Liang; Liu Qiong*; Yang Silin; Song Yun; Ni Jiazuan

doi:10.7536/PC120631

Progress in Chemistry ›› 2013, Vol. 25 ›› Issue (04) : 479-487 DOI: 10.7536/PC120631

Scan to read & Share

Selenoprotein M and Its Effects on Diseases

Chen Ping^1,2, Jiang Liang², Liu Qiong*², Yang Silin³, Song Yun³, Ni Jiazuan²

Author information +

History +

PDF (1264KB)

Abstract

Selenoprotein M (SelM) was discovered in 2002 by bioinformatics analysis. SelM is located in the endoplasmic reticulum, containing a common redox motif cysteine-X-X-selenocysteine. SelM attracts great attention due to its high expression in brain and its potential roles in antioxidative defense, neuroprotective function and cytosolic calcium regulation. This paper reviews recent research progress in SelM, especially its biological function and its relation with diseases, together with the author's work on SelM. The prospect of SelM research is also discussed in this paper.

Contents
1 Introduction
2 The primary structure of SelM and its distribution
3 The spatial structure of SelM
4 The biological function of SelM
4.1 Antioxidative function
4.2 Interaction with metal ions
4.3 Calcium regulation
5 Relation between SelM and diseases
5.1 SelM and AD
5.2 SelM and reproduction and development
5.3 SelM and cancer prevention
6 Perspectives

Keywords

selenoprotein M / oxidative stress / calcium homeostasis / reactive oxygen species(ROS) / ")'>Alzheimer' s disease(AD)

Cite this article

Download citation ▾

Chen Ping, Jiang Liang, Liu Qiong*, Yang Silin, Song Yun, Ni Jiazuan. Selenoprotein M and Its Effects on Diseases. Progress in Chemistry, 2013, 25(04): 479-487 DOI:10.7536/PC120631