Mesoporous silica nanoparticles (MSNs)-based controlled-release system has the characteristics of good biocompatibility, cell targeting property, accurate responsive release, and eliminating undesirable drug release before reaching the target site, which has become a hot topic among many researchers in recent years. This article discussed the advantages of MSNs-based controlled-release system. Meanwhile, based on different stimuli-responsive characteristics, this article systematically analyzed and summarized various MSN-based controlled-release systems which was modified with different responsive switches, and further discussed the switching mechanisms of these devices, including redox-responsive controlled-release systems, light-responsive controlled-release systems, pH-responsive controlled-release systems and biological molecule-responsive controlled-release systems. The prospects and directions of this research field are also briefly addressed. Contents
1 Introduction
2 MSNs-based controlled-release system
3 Non-functionalized MSNs-based controlled-release
4 Functionalized MSNs-based controlled-release
4.1 Redox-responsive controlled-release
4.2 pH-responsive controlled-release
4.3 Light-responsive controlled-release
4.4 Temperature-responsive controlled-release
4.5 Magnet-responsive controlled-release
4.6 Biology-responsive controlled-release
4.7 Multiple responsive controlled-release
4.8 MSNs-based multifunctional systems
5 Outlook