The theory and applications of chemiluminescence (CL) have been investigated for many years, but the study of CL was limited to the molecular and ion systems. Nanoparticles (NPs) have quantum size effects, high surface energy, and large surface area, which dramatically change their density states and the spatial scale of their electronic motion. The redox reactions can be strongly catalyzed by NPs, which is promising for the signal amplification of CL. In the recent years, NP-involved CL became one of the most attractive developments, in which NPs can participate in CL reactions as catalyst,reductant, nanosized reaction platform, and energy acceptor. In this review, the NP-involved luminol CL system and its coupling with separation technology such as high performance liquid chromatography (HPLC), capillary electrophoresis (CE) are described. NPs as a novel response unit of CL system are very important for increasing the luminescent efficiency of luminol reaction and developing new luminol CL system. Different kinds of NPs have been reported to participate luminol CL reaction, including gold (AuNPs), platinum (PtNPs), silver (AgNPs), bimetallic NPs, semiconductor NPs, and magnetic (MNPs). The NP-involved luminol CL is not only widely applied in the environmental, pharmaceutical and food analysis, but also shows great potential in immunoassay. Furthermore, some critical challenges and their possible solutions in the study of NP-involved luminol CL are briefly discussed. Contents
1 Introduction
2 AuNPs-catalyzed luminol CL
2.1 AuNPs-catalyzed luminol-H₂O₂ CL
2.2 AuNPs-catalyzed luminol-ferricyanide CL
2.3 AuNPs-catalyzed luminol-periodate CL
2.4 AuNPs-catalyzed luminol-AgNO₃ CL
2.5 AuNPs-catalyzed other luminol CL
3 PtNPs involved luminol CL
4 AgNPs involved luminol CL
5 Other nanoparticles-involved luminol CL
5.1 Bimetallic nanoparticles-involved luminol CL
5.2 Semiconductor nanoparticles-involved luminol CL
5.3 Magnetic nanoparticles-involved luminol CL
6 Separation technology coupling with nanoparticles-involved luminol CL detection
6.1 Coupling with HPLC
6.2 Coupling with CE
7 Conclusion and outlook