Translational medicine is an emerging concept in the fields of biomedical research and healthcare since twenty-first century. It is a two-way process from the basic research to clinical application with direct feedbacks in between. It is not a new subject, but emphasizes a concept. It stems from an unmet need in clinical medicine. At present, translational medical research is mainly involved in the following areas: cancer, cardiovascular diseases, metabolic disorders, psychiatric disorders, diseases of the locomotor system, genetic diseases, organ transplantation, tissue engineering, disease diagnosis, drug research and development, personalized therapy, stem cell research, animal model studies and immunology etc. This article reviews the bioinorganic chemistry problems involved in the disease diagnosis, tissue engineering, individual therapy, drug research and development and disease mechanisms. Finally, the development of this new area and important issues to be studied are outlooked.Contents
1 The bioinorganic chemistry problems in disease diagnosis
1.1 New diagnosis methods
1.2 Imaging technology
2 The bioinorganic chemistry problems in tissue engineering
3 The bioinorganic chemistry problems in individual therapy
4 The bioinorganic chemistry problems in drug research and development
4.1 From single-target drug design to systematic intervention
4.2 Emerging nanomedicine
5 The bioinorganic chemistry problems in molecular mechanisms of diseases
5.1 The relationship between metal homeostasis and neurodegenerative diseases
5.2 The relationship between oxygen (nitrogen) homeostasis and neurodegenerative diseases
6 Outlook