The oxidation of tetrahydrofuran is an important organic oxidation reaction, the studies of the oxidation of tetrahydrofuran would provide the references and theoretical basis of the α C-H selective activation to other organic matters. Tetrahydrofuran is also a kind of organic chemical raw materials and fine chemical raw materials, therefore the study of tetrahydrofuran oxidation is of very important significance in the field of organic synthesis and industrial production applications. In this paper, the recent progress on the oxidation of tetrahydrofuran is reviewed and the catalytic oxidations of tetrahydrofuran by dioxygen and hydrogen peroxide are introduced with emphasis. Electrochemical oxidation of tetrahydrofuran and several other catalytic oxidation methods of tetrahydrofuran are also summarized. Furthermore, the possible oxidation mechanisms of some important reactions are discussed. Based on the development trends related to the oxidation of tetrahydrofuran in recent years, the hotspots of future research are proposed. Contents
1 Introduction
2 Oxidation of tetrahydrofuran
2.1 Catalytic oxidation of tetrahydrofuran by oxygen
2.2 Catalytic oxidation of tetrahydrofuran by hydrogen peroxide
2.3 Catalytic oxidation of tetrahydrofuran by bromate
2.4 Oxidation of tetrahydrofuran by electrochemical methods
3 Conclusion and outlook