Vinyl chloride is an important functional group in many biologically and pharmaceutically active compounds, some vinyl chloride derivatives have been employed as organic materials, including polymers, and also are employed as the building block in organic synthesis. The construction of vinyl chloride is widely studied, new method and reagent are continuing to emerge in recently years. In this paper, the recent progress in the synthesis of vinyl chloride is reviewed according to the different reaction types, and its application in the total synthesis of marine natural product malyngamides is covered.

Contents
1 Introduction
2 Synthesis of vinyl chloride by Wittig reaction
3 Cr,Pd,Ti,In,Mg,and Cu-mediated reaction to synthesize vinyl chloride
3.1 Organic Cr-mediated reaction
3.2 Pd-mediated reaction
3.3 Ti-mediated reaction
3.4 In-mediated reaction
3.5 MgCl₂-mediated reaction
3.6 Cu-mediated reaction
4 Using other methods to synthesize vinyl chloride
5 Studied on the synthesis of vinyl chloride and applied in marine natural product malyngamides
5.1 Synthesis of vinyl chloride by Wittig reaction in malyngamides M, O, P, Q, R
5.2 Synthesis of vinyl chloride by the reaction of n-Bu₄NI with 1,2-dichloroethane in malyngamides K, L, 5-epi-C
6 Conclusion