Matrix-assisted laser desorption/ionization(MALDI) is one of the most famous ionization methods in mass spectrometry developed in 1980s, and it has been widely applied in the analysis and detection of biological molecules. However,due to the interference from traditional organic matrix in low molar weight region, the application of MALDI in the analysis of low molecular weight samples is very limited. In order to solve the problem,new matrixes including inorganic materials based on carbon,silicon, nano-sized metal particles and some designed organic compounds for the analysis of low molecular weight compounds are investigated. These materials avoid the interference from matrix in the low mass region, and improve the ionization efficiency. In addition, the adding of surfactant to traditional organic matrixes and derivatization of analytes are also efficient methods to analyze low molecular weight compounds. This paper reviews the research progress of these new matrixes and their application in this research field. The tendency of the development of these matrixes and their application are further prospected and discussed.

Contents
1 Introduction
2 Inorganic materials
2.1 Silicon
2.2 Carbon
2.3 Metal or metal oxides
3 Organic molecules
3.1 Designed organic compunds
3.2 High molecular weight organic compounds
4 Ionic liquid
5 Other methods
5.1 Suppression of matrix-related ion
5.2 Derivatization of analyte
5.3 Sol-gels
6 Perspective