Chiral homoallylic alcohols are important drug intermediates for synthesis of pharmaceutical molecules and nature products. Asymmetric carbonyl-ene reaction is a powerful tool for the preparation of them. The chiral catalysts reported include chiral organometallic complexs and chiral organic molecules, which have achieved good catalytic activity and enantioselectivity. This paper reviews the application of various types of chiral catalysts in asymmetric carbonyl-ene reactions, the reaction mechanism of asymmetric induction, the effect of the structure of the catalysts and reaction conditions on the catalytic activity and enantioselectivity.

Contents
1 Introduction
2 Application of chiral organometallic catalysts in carbonyl-ene reaction
2.1 Chiral alkaline earth metal catalyst
2.2 Chiral transition metal catalyst
2.3 Chiral indium catalyst
3 Chiral organocatalyst
3.1 Chiral phosphorus amide
3.2 Chiral binaphthol and its derivatives
4 Conclusion and outlook