The host-guest supramolecular vesicles are attracting more and more attention with the emergence of new host molecules. Cyclodextrin, calixarene, cucurbituril and pillararene can all form supramolecular amphiphiles with specific guest molecules based on host guest recognition, the obtained supramolecular amphiphiles can further self-assembled into the host-guest supramolecular vesicles under mild condition. The host-guest supramolecular vesicles is a sensitively responsive vesicular system, which possesses the advantages of simple preparation, good biocompatibility and controllable self-assembly. This vesicular system has good responsiveness to external stimuli, which can realize drug molecules controllable delivery and release, making it a unique drug delivery system. According to the development of the host molecules recently, the advances of cyclodextrin, calixarene, cucurbituril and pillararene host-guest supramolecular vesicles are introduced firstly. Then the drug delivery ways of this supramolecular vesicles system are summarized, drug molecules can not only be loaded in the cavities and membranes of the host-guest supramolecular vesicles, but also can be loaded in the cavities of the host molecules. Meanwhile, the stimuli (such as pH, ions, redox potential, enzyme, temperature and competitive guests) responsiveness of this drug loaded host-guest supramolecular vesicles is summed up. Finally, the prospects are pointed out based on the current development of this system.

Contents
1 Introduction
2 Different host-guest supramolecular vesicles
2.1 Host-guest supramolecular vesicles of cyclodextrin
2.2 Host-guest supramolecular vesicles of calixarene
2.3 Host-guest supramolecular vesicles of cucurbituril
2.4 Host-guest supramolecular vesicles of pillararene
3 Drug delivery ways of the host-guest supramolecular vesicles
3.1 Drugs loaded in the cavities of the host-guest supramolecular vesicles
3.2 Drugs loaded in the membranes of the host-guest supramolecular vesicles
4 Different stimuli responsiveness of the drug loaded host-guest supramolecular vesicles
4.1 pH response
4.2 Ion response
4.3 Redox response
4.4 Enzyme response
4.5 Temperature response
4.6 Competitive guests response
5 Summary and prospects