Much attention has been paid to the synthesis of 1,3-diynes with the development of its wide applications in the fields of organic synthesis and functional materials. This review describes the synthesis history of the 1,3-diynes and emphatically the synthesis development of 1,3-diynes in recent 10 years. It introduces the new achievements in synthesis of 1,3-diynes from its starting materials including terminal alkynes, alkynyl halides, metal acetylides, alkenyl halides, and other precursors. Medical applications of some reactions and relevant mechanisms are also described in this paper. Finally, the synthesis of 1,3-diynes is concluded and the development trends in the field of 1,3-diynes synthesis are proposed.

Contents
1 Introduction
2 Synthesis from terminal alkynes
2.1 Catalyzed by Pd-Cu
2.2 Catalyzed by Pd
2.3 Catalyzed by Cu
2.4 Other methods from terminal alkynes
3 Synthesis from alkynyl halides
4 Synthesis from metal acetylides
5 Synthesis from alkenyl halides
6 Other methods
7 Conclusion