Mimic enzyme, or artificail enzyme, is a kind of non-protein molecule which is synthesized by the organic chemical method. With the development of nanoscience and supramolecular technology, the establishment of supramolecular artificial enzyme with biocatalytic function has attracted increasingly attention in the field of scientific research and application development. Peptide-based gel is a new type of supramolecular assembly which is formed with polypeptides as the building block and driven by non-covalent forces. As a novel supramolecular material, the peptide-based gel exhibits unique advantages compared with other functional materials:the similar structural and biochemical properties to those of natural enzymes, easy to be modified and functionalized, and the good biocompatibility. These properties make peptide-based gel a ideal material to construct artificial enzyme. In this review, we summarize the characteristics of artificial enzyme based on the assembling peptide gel and introduce the recent research progress of it as the catalysts in hydrolysis, Aldol and redox reactions. The main factors which influence the catalytic activity, such as the assembly degree, structure, active-site microenvironment and pH, are also discussed. Some examples are provided to illustrate the protential application of peptide-based artificial enzyme. Finally, the problems and prospective tendency are presented.

Contents
1 Introduction
2 Reaction types catalyzed by peptide-based artificial enzyme
2.1 Hydrolysis reaction
2.2 Aldol reaction
2.3 Redox reaction
3 Influence factors on the activity of peptide-based artificial enzyme
3.1 Assembly degree
3.2 Microstructure
3.3 Supramolecular structrue
3.4 Active-site microenvironment
3.5 pH
4 Application of peptide-based artificial enzyme
5 Conclusion