Point-of-care testing (POCT) is a test that performed at or near the site of patient care whenever the medical care is needed, POCT has become an indicator of in vitro diagnosis (IVD) because of its simple, rapid, low cost, portable and without being limited by the place. Biosensors possesses characteristics such as rapid, sensitive, high efficiency, portable and easy to automation and miniaturization, so they have great potential in the development of point-of-care testing technology. In recent years, with the development of the biosensor, internet technology and the rise of new and integrated technology, POCT device has obtained substantial progress. In this review, we first briefly introduced the classification of the biosensors and described the state of the art of biosensors that could be performed in POCT, and then reviewed the representative research progress of biosensors in POCT application.According to the emerging technologies, they are classified into microfluidics based biosensors for POCT,paper based biosensors for POCT, nanomaterials based biosensors for POCT, cell phone based biosensors for POCT and the integrated device for POCT. However, the successful commercialization and widespread implementation of such viable technologies remained subject to several challenges and pending issues. Finally, we discussed the current problems, the future development trend and prospects of biosensors for POCT application.

Contents
1 Introduction
2 Current situation of the biosensor in POCT application
3 Microfluidics based biosensors for POCT
3.1 Optical method based detection
3.2 Electrochemical method based detection
4 Paper-based biosensors for POCT
5 Nanomaterials based biosensors for POCT
6 Cell-phone based platforms for POCT
7 Integrated devices for POCT
8 Conclusion