As a sampling and sample preparation technique which is convenient, rapid as well as environmentally-friendly, solid-phase microextraction has attracted widespread attention. Within the scope of its application on in vivo analysis, solid-phase microextraction has been gradually used for highly-efficient detection of various analytes of interest in living animals and plants with the new illustrations on extraction kinetics of solid-phase microextraction, together with development on novel in vivo sampling fibers. In this article we give an overview of the proposal of various calibration methods for quantification, recent investigations on the extraction kinetics of in vivo sampling, and preparations of novel samplers for in vivo solid-phase microextraction, apart from rapid detection of multiple pollutants in living animals or plants, as well as continuous long-term monitoring of uptake and elimination of pollutants therein. Potential application and future trends of development of in vivo solid-phase microextraction are also discussed.
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